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Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5-Lipoxygenase Activating Protein Inhibitor Ericsson, Hans; Nelander, Karin; Lagerstrom-Fermer, Maria; Balendran, Clare; Bhat, Maria; Chialda, Ligia; Gan, Li-Ming; Heijer, Maria; Kjaer, Magnus; Lambert, John; Lindstedt, Eva-Lotte; Forsberg, Gun-Britt; Whatling, Carl; Skrtic, Stanko 分享 收藏
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Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates Sun, Xiuxia; Ponte, Jose F.; Yoder, Nicholas C.; Laleau, Rassol; Coccia, Jennifer; Lanieri, Leanne; Qiu, Qifeng; Wu, Rui; Hong, Erica; Bogalhas, Megan; Wang, Lintao; Dong, Ling; Setiady, Yulius; Maloney, Erin K.; Ab, Olga; Zhang, Xiaoyan; Pinkas, Jan; Keating, Thomas A.; Chari, Ravi; Erickson, Hans K.; Lambert, John M. 分享 收藏
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First-in-human randomized study of bimekizumab, a humanized monoclonal antibody and selective dual inhibitor of IL-17A and IL-17F, in mild psoriasis Glatt, Sophie; Helmer, Eric; Haier, Birgit; Strimenopoulou, Foteini; Price, Graham; Vajjah, Pavan; Harari, Olivier A.; Lambert, John; Shaw, Stevan 分享 收藏
A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity Miller, Michael L.; Fishkin, Nathan E.; Li, Wei; Whiteman, Kathleen R.; Kovtun, Yelena; Reid, Emily E.; Archer, Katie E.; Maloney, Erin K.; Audette, Charlene A.; Mayo, Michele F.; Wilhelm, Alan; Modafferi, Holly A.; Singh, Rajeeva; Pinkas, Jan; Goldmacher, Victor; Lambert, John M.; Chari, Ravi V. J. 分享 收藏
Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates Ponte, Jose F.; Sun, Xiuxia; Yoder, Nicholas C.; Fishkin, Nathan; Laleau, Rassol; Coccia, Jennifer; Lanieri, Leanne; Bogalhas, Megan; Wang, Lintao; Wilhelm, Sharon; Widdison, Wayne; Pinkas, Jan; Keating, Thomas A.; Chari, Ravi; Erickson, Hans K.; Lambert, John M. 分享 收藏
A New Triglycyl Peptide Linker for Antibody-Drug Conjugates (ADCs) with Improved Targeted Killing of Cancer Cells Singh, Rajeeva; Setiady, Yulius Y.; Ponte, Jose; Kovtun, Yelena V.; Lai, Katharine C.; Hong, E. Erica; Fishkin, Nathan; Dong, Ling; Jones, Gregory E.; Coccia, Jennifer A.; Lanieri, Leanne; Veale, Karen; Costoplus, Juliet A.; Skaletskaya, Anna; Gabriel, Rabih; Salomon, Paulin; wu, Rui; Qiu, Qifeng; Erickson, Hans K.; Lambert, John M.; Chari, Ravi V. J.; Widdison, Wayne C. 分享 收藏
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The INNs and outs of antibody nonproprietary names Jones, Tim D.; Carter, Paul J.; Plueckthun, Andreas; Vasquez, Max; Holgate, Robert G. E.; Hoetzel, Isidro; Popplewell, Andrew G.; Parren, Paul W. H. I.; Enzelberger, Markus; Rademaker, Hendrik J.; Clark, Michael R.; Lowe, David C.; Dahiyat, Bassil I.; Smith, Victoria; Lambert, John M.; Wu, Herren; Reilly, Mary; Haurum, John S.; Duebel, Stefan; Huston, James S.; Schirrmann, Thomas; Janssen, Richard A. J.; Steegmaier, Martin; Gross, Jane A.; Bradbury, Andrew R. M.; Burton, Dennis R.; Dimitrov, Dimiter S.; Chester, Kerry A.; Glennie, Martin J.; Davies, Julian; Walker, Adam; Martin, Steve; McCafferty, John; Baker, Matthew P. 分享 收藏
Effects of drug load on therapeutic index for antibody-maytansinoid conjugates Sun, Xiuxia; Ponte, Jose F.; Yoder, Nicholas C.; Coccia, Jennifer; Lanieri, Leanne; Laleau, Rassol; Qiu, Qifeng; Wu, Rui; Hong, Erica; Bogalhas, Megan; Wang, Lintao; Maloney, Erin K.; Ab, Olga; Erickson, Hans K.; Keating, Thomas A.; Chari, Ravi; Lambert, John M. 分享 收藏
IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors Ab, Olga; Whiteman, Kathleen R.; Bartle, Laura M.; Sun, Xiuxia; Singh, Rajeeva; Tavares, Daniel; LaBelle, Alyssa; Payne, Gillian; Lutz, Robert J.; Pinkas, Jan; Goldmacher, Victor S.; Chittenden, Thomas; Lambert, John M. 分享 收藏
PHARMACOKINETIC RESULTS FROM A PHASE 1, SINGLE-CENTRE, DOUBLE-BLIND, RANDOMISED, SINGLE-DOSE, PARALLEL GROUP STUDY COMPARING 5 MG/KG IV INFUSION OF BOW015 AND REFERENCE INFLIXIMAB IN HEALTHY MALE VOLUNTEERS Lambert, J.; Wyand, M.; Lassen, C.; Shneyer, L.; Thomson, E.; Kay, J. 分享 收藏
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Effects of JNJ-40929837, a leukotriene A4 hydrolase inhibitor, in a bronchial allergen challenge model of asthma Barchuk, W.; Lambert, J.; Fuhr, R.; Jiang, J. Z.; Bertelsen, K.; Fourie, A.; Liu, X.; Silkoff, P. E.; Barnathan, E. S.; Thurmond, R. 分享 收藏
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Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models Lorvotuzumab mertansine，一种CD56-targeting抗体-药物缀合物，在人类异种移植模型中对小细胞肺癌具有有效的抗肿瘤活性 Whiteman, Kathleen R.; Johnson, Holly A.; Mayo, Michele F.; Audette, Charlene A.; Carrigan, Christina N.; LaBelle, Alyssa; Zukerberg, Lawrence; Lambert, John M.; Lutz, Robert J. 分享 收藏
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