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L

Laura Sepp-Lorenzino

intellia therapeutics, cambridge, massachusetts, usa
H指数:44
被引数:8,295

个人简介

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教育背景

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工作经历

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荣誉奖项

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CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema

KLKB1基因编辑在遗传性血管性水肿中的体内CRISPR-Cas9

NEW ENGLAND JOURNAL OF MEDICINE
IF78.5
2024-02-0145
PRE
Longhurst, Hilary J.; Lindsay, Karen; Petersen, Remy S.; Fijen, Laure M.; Gurugama, Padmalal; Maag, David; Butler, James S.; Shah, Mrinal Y.; Golden, Adele; Xu, Yuanxin; Boiselle, Carri; Vogel, Joseph D.; Abdelhady, Ahmed M.; Maitland, Michael L.; McKee, Mark D.; Seitzer, Jessica; Han, Bo W.; Soukamneuth, Samantha; Leonard, John; Sepp-Lorenzino, Laura; Clark, Eliana D.; Lebwohl, David; Cohn, Danny M.
Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials
JOURNAL OF HEPATOLOGY
IF33
2023-10-0135
OA
Gane, Ed; Lim, Young-Suk; Kim, Jae B.; Jadhav, Vasant; Shen, Ling; Bakardjiev, Anna I.; Huang, Stephen A.; Cathcart, Andrea L.; Lempp, Florian A.; Janas, Maja M.; Cloutier, Daniel J.; Kaittanis, Charalambos; Sepp-Lorenzino, Laura; Hinkle, Gregory; Taubel, Jorg; Haslett, Patrick; Milstein, Stuart; Anglero-Rodriguez, Yesseinia I.; Hebner, Christy M.; Pang, Phillip S.; Yuen, Man-Fung
From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization
NUCLEIC ACIDS RESEARCH
IF13.1
2022-06-2343
OAAI
Schlegel, Mark K.; Janas, Maja M.; Jiang, Yongfeng; Barry, Joseph D.; Davis, Wendell; Agarwal, Saket; Berman, Daniel; Brown, Christopher R.; Castoreno, Adam; LeBlanc, Sarah; Liebow, Abigail; Mayo, Tara; Milstein, Stuart; Nguyen, Tuyen; Shulga-Morskaya, Svetlana; Hyde, Sarah; Schofield, Sally; Szeto, John; Woods, Lauren Blair; Yilmaz, Vedat O.; Manoharan, Muthiah; Egli, Martin; Charisse, Klaus; Sepp-Lorenzino, Laura; Haslett, Patrick; Fitzgerald, Kevin; Jadhav, Vasant; Maier, Martin A.
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

转甲状腺素蛋白淀粉样变性的体内基因编辑CRISPR-Cas9

NEW ENGLAND JOURNAL OF MEDICINE
IF78.5
2021-08-05934
OAAI
Gillmore, Julian D.; Gane, Ed; Taubel, Jorg; Kao, Justin; Fontana, Marianna; Maitland, Michael L.; Seitzer, Jessica; O'Connell, Daniel; Walsh, Kathryn R.; Wood, Kristy; Phillips, Jonathan; Xu, Yuanxin; Amaral, Adam; Boyd, Adam P.; Cehelsky, Jeffrey E.; McKee, Mark D.; Schiermeier, Andrew; Harari, Olivier; Murphy, Andrew; Kyratsous, Christos A.; Zambrowicz, Brian; Soltys, Randy; Gutstein, David E.; Leonard, John; Sepp-Lorenzino, Laura; Lebwohl, David
Centyrin ligands for extrahepatic delivery of siRNA
MOLECULAR THERAPY
IF12
2021-06-0131
OAAI
Klein, Donna; Goldberg, Shalom; Theile, Christopher S.; Dambra, Richard; Haskell, Kathleen; Kuhar, Elise; Lin, Tricia; Parmar, Rubina; Manoharan, Muthiah; Richter, Mark; Wu, Meizhen; Zarazowski, Jeannine Mendrola; Jadhav, Vasant; Maier, Martin A.; Sepp-Lorenzino, Laura; O'Neil, Karyn; Dudkin, Vadim
Safety evaluation of 2-deoxy-2-fluoro nucleotides in GalNAc-siRNA conjugates
NUCLEIC ACIDS RESEARCH
IF13.1
2019-03-0161
OAAI
Janas, Maja M.; Zlatev, Ivan; Liu, Ju; Jiang, Yongfeng; Barros, Scott A.; Sutherland, Jessica E.; Davis, Wendell P.; Liu, Jingxuan; Brown, Christopher R.; Liu, Xiumin; Schlegel, Mark K.; Blair, Lauren; Zhang, Xuemei; Das, Biplab; Tran, Chris; Aluri, Krishna; Li, Jing; Agarwal, Saket; Indrakanti, Ramesh; Charisse, Klaus; Nair, Jayaprakash; Matsuda, Shigeo; Rajeev, Kallanthottathil G.; Zimmermann, Tracy; Sepp-Lorenzino, Laura; Xu, Yuanxin; Akinc, Akin; Fitzgerald, Kevin; Vaishnaw, Akshay K.; Smith, Peter F.; Manoharan, Muthiah; Jadhav, Vasant; Wu, Jing-Tao; Maier, Martin A.
Titrating haemophilia B phenotypes using siRNA strategy: evidence that antithrombotic activity is separated from bleeding liability
THROMBOSIS AND HAEMOSTASIS
IF4.3
2017-11-228
PREAI
Metzger, Joseph M.; Tadin-Strapps, Marija; Thankappan, Anil; Strapps, Walter R.; DiPietro, Marti; Leander, Karen; Zhang, Zuo; Shin, Myung K.; Levorse, John; Desai, Kunal; Xu, Yiming; Lai, KehDih; Wu, Weizhen; Chen, Zhu; Cai, Tian-Quan; Jochnowitz, Nina; Bentley, Ross; Hoos, Lizbeth; Zhou, Yuchen; Sepp-Lorenzino, Laura; Seiffert, Dietmar; Andre, Patrick
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit
MOLECULAR THERAPY-NUCLEIC ACIDS
IF0
2015-01-0128
OAAI
Chen, Zhu; Luo, Bin; Cai, Tian-Quan; Thankappan, Anil; Xu, Yiming; Wu, Weizhen; DiMuzio, Jillian; Lifsted, Traci; DiPietro, Marty; Disa, Jyoti; Ng, Bruce; Leander, Karen; Clark, Seth; Hoos, Lizbeth; Zhou, Yuchen; Jochnowitz, Nina; Jachec, Christine; Szczerba, Peter; Gindy, Marian E.; Strapps, Walter; Sepp-Lorenzino, Laura; Seiffert, Dietmar A.; Lubbers, Laura; Tadin-Strapps, Marija
An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo
CANCER BIOLOGY & THERAPY
IF4.6
2014-10-2758
OAAI
Cherrin, Craig; Haskell, Kathleen; Howell, Bonnie; Jones, Raymond; Leander, Karen; Robinson, Ronald; Watkins, Aubrey; Bilodeau, Mark; Hoffman, Jacob; Sanderson, Philip; Hartman, George; Mahan, Elizabeth; Prueksantanont, Thomayant; Jiang, Guoqiang; She, Qing-Bai; Rosen, Neal; Sepp-Lorenzino, Laura; Defeo-Jones, Deborah; Huber, Hans E.

研究方向

暂未获取到该数据
N
Neal Rosen
H 指数:126论文数:998被引数:5.4万
V
Vasant Jadhav
H 指数:27论文数:60被引数:4,335
B
Bonnie J. Howell
H 指数:33论文数:127被引数:6,470
R
Rubina Parmar
H 指数:13论文数:27被引数:1,030
J
Joseph P. Davide
H 指数:29论文数:71被引数:3,867
S
Samuel J. Danishefsky
H 指数:111论文数:1,329被引数:5.1万
J
Jessica Seitzer
H 指数:12论文数:32被引数:3,015
S
Stuart Milstein
H 指数:36论文数:103被引数:1.2万
K
Karen Leander
H 指数:22论文数:50被引数:4,537
M
Marc Abrams
H 指数:29论文数:115被引数:2,808