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Docking 14 Million Virtual Isoquinuclidines against the μ and κ Opioid Receptors Reveals Dual Antagonists-Inverse Agonists with Reduced Withdrawal Effects 对接1400万种虚拟异喹啉啶化合物与μ和κ阿片受体，发现具有双重拮抗剂-反向激动剂特性且戒断效应减弱的化合物 Vigneron, SF; Ohno, S; Braz, J; Kim, JY; Kweon, OS; Webb, C; Billesbolle, CB; Srinivasan, K; Bhardwaj, K; Irwin, JJ; Manglik, A; Basbaum, AI; Ellman, JA; Shoichet, BK 分享 收藏
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Structural basis of μ-opioid receptor targeting by a nanobody antagonist Yu, Jun; Kumar, Amit; Zhang, Xuefeng; Martin, Charlotte; Van Holsbeeck, Kevin; Raia, Pierre; Koehl, Antoine; Laeremans, Toon; Steyaert, Jan; Manglik, Aashish; Ballet, Steven; Boland, Andreas; Stoeber, Miriam 分享 收藏
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GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway Hoppe, Nicholas; Harrison, Simone; Hwang, Sun-Hee; Chen, Ziwei; Karelina, Masha; Deshpande, Ishan; Suomivuori, Carl-Mikael; Palicharla, Vivek R.; Berry, Samuel P.; Tschaikner, Philipp; Regele, Dominik; Covey, Douglas F.; Stefan, Eduard; Marks, Debora S.; Reiter, Jeremy F.; Dror, Ron O.; Evers, Alex S.; Mukhopadhyay, Saikat; Manglik, Aashish 分享 收藏
Rare antibody phage isolation and discrimination (RAPID) biopanning enables identification of high-affinity antibodies against challenging targets Chung, Dong Hee; Kong, Sophie; Young, Nicholas J.; Chuo, Shih-Wei; Shiah, Jamie V.; Connelly, Emily J.; Rohweder, Peter J.; Born, Alexandra; Manglik, Aashish; Grandis, Jennifer R.; Johnson, Daniel E.; Craik, Charles S. 分享 收藏
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Selective G protein signaling driven by substance P-neurokinin receptor dynamics Harris, Julian A.; Faust, Bryan; Gondin, Arisbel B.; Damgen, Marc Andre; Suomivuori, Carl-Mikael; Veldhuis, Nicholas A.; Cheng, Yifan; Dror, Ron O.; Thal, David M.; Manglik, Aashish 分享 收藏
Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL Nix, Matthew A.; Mandal, Kamal; Geng, Huimin; Paranjape, Neha; Lin, Yu-Hsiu T.; Rivera, Jose M.; Marcoulis, Makeba; White, Kristie L.; Whitman, Jeffrey D.; Bapat, Sagar P.; Parker, Kevin R.; Ramirez, Jonathan; Deucher, Anne; Phojanokong, Paul; Steri, Veronica; Fattahi, Faranak; Hann, Byron C.; Satpathy, Ansuman T.; Manglik, Aashish; Stieglitz, Elliot; Wiita, Arun P. 分享 收藏
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Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit Zhang, Yunxiao; Lu, Wan-Jin; Bulkley, David P.; Liang, Jiahao; Ralko, Arthur; Han, Shuo; Roberts, Kelsey J.; Li, Anping; Cho, Wonhwa; Cheng, Yifan; Manglik, Aashish; Beachy, Philip A. 分享 收藏
Universal Polymerase Chain Reaction and Antibody Testing Demonstrate Little to No Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 in a Rural Community Appa, Ayesha; Takahashi, Saki; Rodriguez-Barraquer, Isabel; Chamie, Gabriel; Sawyer, Aenor; Duarte, Elias; Hakim, Jill; Turcios, Keirstinne; Vinden, Joanna; Janson, Owen; Manglik, Aashish; Peluso, Michael J.; Deeks, Steven G.; Henrich, Timothy J.; Torres, Leonel; Rodgers, Mary; Hackett, John; Chiu, Charles; Havlir, Diane; Greenhouse, Bryan 分享 收藏
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance SARS-CoV-2血清学测定的评估揭示了一系列测试性能 Whitman, Jeffrey D.; Hiatt, Joseph; Mowery, Cody T.; Shy, Brian R.; Yu, Ruby; Yamamoto, Tori N.; Rathore, Ujjwal; Goldgof, Gregory M.; Whitty, Caroline; Woo, Jonathan M.; Gallman, Antonia E.; Miller, Tyler E.; Levine, Andrew G.; Nguyen, David N.; Bapat, Sagar P.; Balcerek, Joanna; Bylsma, Sophia A.; Lyons, Ana M.; Li, Stacy; Wong, Allison Wai-yi; Gillis-Buck, Eva Mae; Steinhart, Zachary B.; Lee, Youjin; Apathy, Ryan; Lipke, Mitchell J.; Smith, Jennifer Anne; Zheng, Tina; Boothby, Ian C.; Isaza, Erin; Chan, Jackie; Acenas, Dante D., II; Lee, Jinwoo; Macrae, Trisha A.; Kyaw, Than S.; Wu, David; Ng, Dianna L.; Gu, Wei; York, Vanessa A.; Eskandarian, Haig Alexander; Callaway, Perri C.; Warrier, Lakshmi; Moreno, Mary E.; Levan, Justine; Torres, Leonel; Farrington, Lila A.; Loudermilk, Rita P.; Koshal, Kanishka; Zorn, Kelsey C.; Garcia-Beltran, Wilfredo F.; Yang, Diane; Astudillo, Michael G.; Bernstein, Bradley E.; Gelfand, Jeffrey A.; Ryan, Edward T.; Charles, Richelle C.; Iafrate, A. John; Lennerz, Jochen K.; Miller, Steve; Chiu, Charles Y.; Stramer, Susan L.; Wilson, Michael R.; Manglik, Aashish; Ye, Chun Jimmie; Krogan, Nevan J.; Anderson, Mark S.; Cyster, Jason G.; Ernst, Joel D.; Wu, Alan H. B.; Lynch, Kara L.; Bern, Caryn; Hsu, Patrick D.; Marson, Alexander 分享 收藏
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