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收藏The novel family of Warbicin® compounds inhibits glucose uptake both in yeast and human cells and restrains cancer cell proliferation
Vanthienen, Ward; Fernandez-Garcia, Juan; Baietti, Maria Francesca; Claeys, Elisa; Van Leemputte, Frederik; Nguyen, Long; Goossens, Vera; Deparis, Quinten; Broekaert, Dorien; Vlayen, Sophie; Audenaert, Dominique; Delforge, Michel; D'Amuri, Alessandro; Van Zeebroeck, Griet; Leucci, Eleonora; Fendt, Sarah-Maria; Thevelein, Johan M. 分享 收藏 A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling富含棕榈酸酯的转移生态位通过p65乙酰化实现转移生长，从而导致促转移nf-κb信号传导Altea-Manzano, Patricia; Doglioni, Ginevra; Liu, Yawen; Cuadros, Alejandro M.; Nolan, Emma; Fernandez-Garcia, Juan; Wu, Qi; Planque, Melanie; Laue, Kathrin Julia; Cidre-Aranaz, Florencia; Liu, Xiao-Zheng; Marin-Bejar, Oskar; Van Elsen, Joke; Vermeire, Ines; Broekaert, Dorien; Demeyer, Sofie; Spotbeen, Xander; Idkowiak, Jakub; Montagne, Aurelie; Demicco, Margherita; Alkan, H. Furkan; Rabas, Nick; Riera-Domingo, Carla; Richard, Francois; Geukens, Tatjana; De Schepper, Maxim; Leduc, Sophia; Hatse, Sigrid; Lambrechts, Yentl; Kay, Emily Jane; Lilla, Sergio; Alekseenko, Alisa; Geldhof, Vincent; Boeckx, Bram; de la Calle Arregui, Celia; Floris, Giuseppe; Swinnen, Johannes V.; Marine, Jean-Christophe; Lambrechts, Diether; Pelechano, Vicent; Mazzone, Massimiliano; Zanivan, Sara; Cools, Jan; Wildiers, Hans; Baud, Veronique; Gruenewald, Thomas G. P.; Ben-David, Uri; Desmedt, Christine; Malanchi, Ilaria; Fendt, Sarah-Maria 分享 收藏 CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiationFernandez-Garcia, Juan; Franco, Fabien; Parik, Sweta; Altea-Manzano, Patricia; Pane, Antonino Alejandro; Broekaert, Dorien; van Elsen, Joke; Vermeire, Ines; Schalley, Tessa; Planque, Melanie; van Brussel, Thomas; Schepers, Rogier; Modave, Elodie; Karakach, Tobias K.; Carmeliet, Peter; Lambrechts, Diether; Ho, Ping-Chih; Fendt, Sarah-Maria 分享 收藏 Altered propionate metabolism contributes to tumour progression and aggressivenessGomes, Ana P.; Ilter, Didem; Low, Vivien; Drapela, Stanislav; Schild, Tanya; Mullarky, Edouard; Han, Julie; Elia, Ilaria; Broekaert, Dorien; Rosenzweig, Adam; Nagiec, Michal; Nunes, Joana B.; Schaffer, Bethany E.; Mutvei, Anders P.; Asara, John M.; Cantley, Lewis C.; Fendt, Sarah-Maria; Blenis, John 分享 收藏 Macrophages are metabolically heterogeneous within the tumor microenvironmentGeeraerts, Xenia; Fernandez-Garcia, Juan; Hartmann, Felix J.; de Goede, Kyra E.; Martens, Liesbet; Elkrim, Yvon; Debraekeleer, Ayla; Stijlemans, Benoit; Vandekeere, Anke; Rinaldi, Gianmarco; De Rycke, Riet; Planque, Melanie; Broekaert, Dorien; Meinster, Elisa; Clappaert, Emile; Bardet, Pauline; Murgaski, Aleksandar; Gysemans, Conny; Nana, Frank Aboubakar; Saeys, Yvan; Bendall, Sean C.; Laoui, Damya; Van den Bossche, Jan; Fendt, Sarah-Maria; Van Ginderachter, Jo A. 分享 收藏 Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis脂肪在非转化肝细胞中诱导葡萄糖代谢并促进肝脏肿瘤发生Broadfield, Lindsay A.; Duarte, Joao Andre Goncalves; Schmieder, Roberta; Broekaert, Dorien; Veys, Koen; Planque, Melanie; Vriens, Kim; Karasawa, Yasuaki; Napolitano, Francesco; Fujita, Suguru; Fujii, Masashi; Eto, Miki; Holvoet, Bryan; Vangoitsenhoven, Roman; Fernandez-Garcia, Juan; Van Elsen, Joke; Dehairs, Jonas; Zeng, Jia; Dooley, James; Rubio, Rebeca Alba; van Pelt, Jos; Gruenewald, Thomas G. P.; Liston, Adrian; Mathieu, Chantal; Deroose, Christophe M.; Swinnen, Johannes, V; Lambrechts, Diether; di Bernardo, Diego; Kuroda, Shinya; De Bock, Katrien; Fendt, Sarah-Maria 分享 收藏 In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 InhibitionRinaldi, Gianmarco; Pranzini, Erica; Van Elsen, Joke; Broekaert, Dorien; Funk, Cornelius M.; Planque, Melanie; Doglioni, Ginevra; Altea-Manzano, Patricia; Rossi, Matteo; Geldhof, Vincent; Teoh, Shao Thing; Ross, Christina; Hunter, Kent W.; Lunt, Sophia Y.; Gruenewald, Thomas G. P.; Fendt, Sarah-Maria 分享 收藏 mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate BiosynthesisTriki, Mouna; Rinaldi, Gianmarco; Planque, Melanie; Broekaert, Dorien; Winkelkotte, Alina M.; Maier, Carina R.; Raman, Sudha Janaki; Vandekeere, Anke; Van Elsen, Joke; Orth, Martin F.; Gruenewald, Thomas G. P.; Schulze, Almut; Fendt, Sarah-Maria 分享 收藏 High fat diet induces a tumor like metabolism in the liverDuarte, J.; Schmieder, R.; Veys, K.; Broekaert, D.; Napolitano, F.; Holvoet, B.; Gilis, M.; Vriens, K.; Garcia, J. F.; Gruenewald, T.; Mathieu, C.; Deroose, C.; Bernardo, D. D.; de Bock, K.; Fendt, S. -M. 分享 收藏 Multipotent adult progenitor cells improve the hematopoietic function in myelodysplasiaRoobrouck, Valerie D.; Wolfs, Esther; Delforge, Michel; Broekaert, Dorien; Chakraborty, Soumen; Sels, Kathleen; Vanwelden, Thomas; Holvoet, Bryan; Lhoest, Larissa; Khurana, Satish; Pandey, Shubham; Hoornaert, Chloe; Ponsaerts, Peter; Struys, Tom; Boeckx, Nancy; Vandenberghe, Peter; Deroose, Christophe M.; Verfaillie, Catherine M. 分享 收藏 分享 收藏 Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis乳腺癌来源的肺转移显示丙酮酸羧化酶依赖性回补增加Christen, Stefan; Lorendeau, Doriane; Schmieder, Roberta; Broekaert, Dorien; Metzger, Kristine; Veys, Koen; Elia, Ilaria; Buescher, Joerg Martin; Orth, Martin Franz; Davidson, Shawn Michael; Gruenewald, Thomas Georg Philipp; De Bock, Katrien; Fendt, Sarah-Maria 分享 收藏 Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism氧传感器PHD1的缺失或抑制通过神经元代谢的重编程防止缺血性中风Quaegebeur, Annelies; Segura, Inmaculada; Schmieder, Roberta; Verdegem, Dries; Decimo, Ilaria; Bifari, Francesco; Dresselaers, Tom; Eelen, Guy; Ghosh, Debapriva; Davidson, Shawn M.; Schoors, Sandra; Broekaert, Dorien; Cruys, Bert; Govaerts, Kristof; De Legher, Carla; Bouche, Ann; Schoonjans, Luc; Ramer, Matt S.; Hung, Gene; Bossaert, Goele; Cleveland, Don W.; Himmelreich, Uwe; Voets, Thomas; Lemmens, Robin; Bennett, C. Frank; Robberecht, Wim; De Bock, Katrien; Dewerchin, Mieke; Ghesquiere, Bart; Fendt, Sarah-Maria; Carmeliet, Peter 分享 收藏 Alternative Routes to Induce Naive Pluripotency in Human Embryonic Stem Cells在人类胚胎干细胞中诱导幼稚多能性的替代途径Duggal, Galbha; Warrier, Sharat; Ghimire, Sabitri; Broekaert, Dorien; Van der Jeught, Margot; Lierman, Sylvie; Deroo, Tom; Peelman, Luc; Van Soom, Ann; Cornelissen, Ria; Menten, Bjorn; Mestdagh, Pieter; Vandesompele, Jo; Roost, Matthias; Slieker, Roderick C.; Heijmans, Bastiaan T.; Deforce, Dieter; De Sutter, Petra; Lopes, Susana Chuva De Sousa; Heindryckx, Bjorn 分享 收藏 分享 收藏 分享 收藏 分享 收藏 
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