Douglas F. Covey - Publications, H-index & Citations

Douglas F. Covey

washington university

72H指数

454论文数

1.7W被引数

收录论文 169

发表时间

The orientation of cholesterol’s hydroxy group affects its membrane dynamics and intracellular transport 胆固醇羟基的取向影响其膜动态和细胞内运输

iScience

IF4.1

2026-09-15

OAAI

Line Lauritsen; Amanda Therese Pauli; Miklas P.W. Larsen; Peter Reinholdt; Holger A. Scheidt; Yuanjian Xu; Douglas F. Covey; Laura Depta; Hogan P. Bryce-Rogers; Luca Laraia; Jacob Kongsted; Daniel Wüstner

Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis 作者更正: 7-脱氢胆固醇是铁死亡的内源性抑制因子

Nature

IF48.5

2026-03-24

PREAI

Florencio Porto Freitas; Hamed Alborzinia; Ancély Ferreira dos Santos; Palina Nepachalovich; Lohans Pedrera; Omkar Zilka; Alex Inague; Corinna Klein; Nesrine Aroua; Kamini Kaushal; Bettina Kast; Svenja M. Lorenz; Viktoria Kunz; Helene Nehring; Thamara N. Xavier da Silva; Zhiyi Chen; Sena Atici; Sebastian G. Doll; Emily L. Schaefer; Ifedapo Ekpo; Werner Schmitz; Aline Horling; Peter Imming; Sayuri Miyamoto; Ann M. Wehman; Thiago C. Genaro-Mattos; Karoly Mirnics; Lokender Kumar; Judith Klein-Seetharaman; Svenja Meierjohann; Isabel Weigand; Matthias Kroiss; Georg W. Bornkamm; Fernando Gomes; Luis Eduardo Soares Netto; Manjima B. Sathian; David B. Konrad; Douglas F. Covey; Bernhard Michalke; Kurt Bommert; Ralf C. Bargou; Ana Garcia-Saez; Derek A. Pratt; Maria Fedorova; Andreas Trumpp; Marcus Conrad; José Pedro Friedmann Angeli

Live-Cell Imaging and Lipidomics of Low-Density Lipoprotein Containing Intrinsically Fluorescent Cholesteryl Esters 活细胞成像和富含固有荧光胆固醇酯的低密度脂蛋白脂质组学

Analytical Chemistry

IF6.7

2026-02-26

OAAI

Alice Dupont Juhl; Richard R. Sprenger; Maciej Modzel; Senjuti Halder; Maria Szomek; Vibeke Akkerman; Yuanjian Xu; Christian W. Heegaard; Christer S. Ejsing; Douglas F. Covey; Daniel Wüstner

Bioactive lipid-mediated structural and functional regulation of the essential human potassium channel Kir7.1 生物活性脂质介导的人体关键钾离子通道Kir7.1的结构与功能调控

Nature Communications

IF15.7

2026-02-11

OAAI

Qingwei Niu; Simon Vu; Yuanjiang Xu; Mingxing Qian; Anastasiia Rudenko; Jin Ye; Jianwei Zeng; Wei Huang; Douglas F. Covey; Rui Zhang; Ziao Fu; Polina V. Lishko

Target validation uncouples mitochondrial translocator protein from 19-Atriol-mediated inhibition of steroidogenesis and identifies enzymatic targets 靶向验证解除了线粒体转位蛋白与19-表雄酮介导的类固醇生成的抑制作用，并确定了酶学靶点。

Journal of Biological Chemistry

IF3.9

2026-01-23

OAAI

Amy H. Zhao; Prasanthi P. Koganti; Mingxing Qian; Anthony Garcia; Patrick O’Day; Richard J. Auchus; Douglas F. Covey; Vimal Selvaraj

Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery 解析神经类固醇的多方面作用：机器学习与体外筛选用于新靶点发现

British Journal of Pharmacology

IF7.7

2025-06-24

PREAI

Ajeet Kumar; Mingxing Qian; Yuanjian Xu; Ann Benz; Douglas F. Covey; Charles F. Zorumski; Steven Mennerick

Endogenous and fluorescent sterols reveal the molecular basis for ligand selectivity of human sterol transporters

JOURNAL OF LIPID RESEARCH

IF4.1

2025-02-01

OAAI

Depta, Laura; Bryce-Rogers, Hogan P.; Dekker, Nienke J.; Bonke, Anna Wiehl; Camporese, Nicolo; Qian, Mingxing; Xu, Yuanjian; Covey, Douglas F.; Laraia, Luca

Stereospecific Properties and Intracellular Transport of Novel Intrinsically Fluorescent Neurosteroids

ACS CHEMICAL NEUROSCIENCE

IF3.9

2024-11-22

PREAI

Akkerman, Vibeke; Reinholdt, Peter; Schnoor-Madsen, Rasmus; Lauritsen, Line; Bader, Jad; Qian, Minxing; Xu, Yuanjiang; Akk, Gustav; Scheidt, Holger A.; Mueller, Peter; Covey, Douglas F.; Evers, Alex S.; Kongsted, Jacob; Wustner, Daniel

Inhibitory Actions of Potentiating Neuroactive Steroids in the Human a1b3g2L g-Aminobutyric Acid Type A ReceptorS

MOLECULAR PHARMACOLOGY

IF3

2024-11-01

OAAI

Pierce, Spencer R.; Germann, Allison L.; Covey, Douglas F.; Evers, Alex S.; Steinbach, Joe Henry; Akk, Gustav

Direct measurements of neurosteroid binding to specific sites on GABAA receptors

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2024-07-08

OAAI

Chintala, Satyanarayana M.; Tateiwa, Hiroki; Qian, Mingxing; Xu, Yuanjian; Amtashar, Fatima; Chen, Zi-Wei; Kirkpatrick, Charles C.; Bracamontes, John; Germann, Allison L.; Akk, Gustav; Covey, Douglas F.; Evers, Alex S.

Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay

ACS CHEMICAL NEUROSCIENCE

IF3.9

2024-02-22

PREAI

Germann, Allison L.; Xu, Yuanjian; Covey, Douglas F.; Evers, Alex S.; Akk, Gustav

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2024-02-07

OAAI

Hoppe, Nicholas; Harrison, Simone; Hwang, Sun-Hee; Chen, Ziwei; Karelina, Masha; Deshpande, Ishan; Suomivuori, Carl-Mikael; Palicharla, Vivek R.; Berry, Samuel P.; Tschaikner, Philipp; Regele, Dominik; Covey, Douglas F.; Stefan, Eduard; Marks, Debora S.; Reiter, Jeremy F.; Dror, Ron O.; Evers, Alex S.; Mukhopadhyay, Saikat; Manglik, Aashish

Neuroactive steroid effects on autophagy in a human embryonic kidney 293 (HEK) cell model

SCIENTIFIC REPORTS

IF3.9

2024-01-10

OAAI

Salvatore, Sofia V.; Ilagan, Ma. Xenia G.; Shu, Hongjin; Lambert, Peter M.; Benz, Ann; Qian, Mingxing; Covey, Douglas F.; Zorumski, Charles F.; Mennerick, Steven

Neurosteroid enantiomers as potentially novel neurotherapeutics

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

IF7.9

2023-06-01

OAAI

Covey, Douglas F.; Evers, Alex S.; Izumi, Yukitoshi; Maguire, Jamie L.; Mennerick, Steven J.; Zorumski, Charles F.

Sex-specific hypnotic effects of the neuroactive steroid (3b,5b,17b)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid

BRITISH JOURNAL OF ANAESTHESIA

IF9.2

2023-02-01

OAAI

Manzella, Francesca M.; Cabrera, Omar H.; Wilkey, Davis; Fine-Raquet, Brier; Klawitter, Jelena; Krishnan, Kathiresan; Covey, Douglas F.; Jevtovic-Todorovic, Vesna; Todorovic, Slobodan M.

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

SCIENCE ADVANCES

IF12.5

2022-06-03

OAAI

Kinnebrew, Maia; Woolley, Rachel E.; Ansell, T. Bertie; Byrne, Eamon F. X.; Frigui, Sara; Luchetti, Giovanni; Sircar, Ria; Nachtergaele, Sigrid; Mydock-McGrane, Laurel; Krishnan, Kathiresan; Newstead, Simon; Sansom, Mark S. P.; Covey, Douglas F.; Siebold, Christian; Rohatgi, Rajat

Discovery of the first tight-binding reversible antagonists of Hedgehog protein autoprocessing

FASEB JOURNAL

IF4.2

2022-05-13

PREAI

Wagner, Andrew G.; Stagnitta, Robert T.; Xu, Zihan; Pezzullo, John L.; Kandel, Nabin; Giner, Jose-Luis; Covey, Douglas F.; Wang, Chunyu; Callahan, Brian P.

Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future 合成神经活性类固醇作为新的镇静剂和麻醉剂: 回溯未来

JOURNAL OF NEUROENDOCRINOLOGY

IF4.1

2022-01-10

OAAI

Manzella, Francesca M.; Covey, Douglas F.; Jevtovic-Todorovic, Vesna; Todorovic, Slobodan M.

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling

NATURE COMMUNICATIONS

IF15.7

2021-12-09

OAAI

Griffiths, Samuel C.; Schwab, Rebekka A.; El Omari, Kamel; Bishop, Benjamin; Iverson, Ellen J.; Malinauskas, Tomas; Dubey, Ramin; Qian, Mingxing; Covey, Douglas F.; Gilbert, Robert J. C.; Rohatgi, Rajat; Siebold, Christian

Differential effects of the novel neurosteroid hypnotic (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats

BRITISH JOURNAL OF ANAESTHESIA

IF9.2

2021-09-01

OAAI

Joksimovic, Srdjan M.; Sampath, Dayalan; Krishnan, Kathiresan; Covey, Douglas F.; Jevtovic-Todorovic, Vesna; Raol, Yogendra H.; Todorovic, Slobodan M.

研究方向