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A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins Ackloo, Suzanne; Li, Fengling; Szewczyk, Magda; Seitova, Almagul; Loppnau, Peter; Zeng, Hong; Xu, Jin; Ahmad, Shabbir; Arnautova, Yelena A.; Baghaie, A. J.; Beldar, Serap; Bolotokova, Albina; Centrella, Paolo A.; Chau, Irene; Clark, Matthew A.; Cuozzo, John W.; Dehghani-Tafti, Saba; Disch, Jeremy S.; Dong, Aiping; Dumas, Antoine; Feng, Jianwen A.; Ghiabi, Pegah; Gibson, Elisa; Gilmer, Justin; Goldman, Brian; Green, Stuart R.; Guie, Marie-Aude; Guilinger, John P.; Harms, Nathan; Herasymenko, Oleksandra; Houliston, Scott; Hutchinson, Ashley; Kearnes, Steven; Keefe, Anthony D.; Kimani, Serah W.; Kramer, Trevor; Kutera, Maria; Kwak, Haejin A.; Lento, Cristina; Li, Yanjun; Liu, Jenny; Loup, Joachim; Machado, Raquel A. C.; Mulhern, Christopher J.; Perveen, Sumera; Righetto, Germanna L.; Riley, Patrick; Shrestha, Suman; Sigel, Eric A.; Silva, Madhushika; Sintchak, Michael D.; Slakman, Belinda L.; Taylor, Rhys D.; Thompson, James; Torng, Wen; Underkoffler, Carl; von Rechenberg, Moritz; Walsh, Ryan T.; Watson, Ian; Wilson, Derek J.; Wolf, Esther; Yadav, Manisha; Yazdi, Aliakbar K.; Zhang, Junyi; Zhang, Ying; Santhakumar, Vijayaratnam; Edwards, Aled M.; Barsyte-Lovejoy, Dalia; Schapira, Matthieu; Brown, Peter J.; Halabelian, Levon; Arrowsmith, Cheryl H. 分享 收藏
Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen Lucas, Simon C. C.; Blackwell, J. Henry; Borjesson, Ulf; Hargreaves, David; Milbradt, Alexander G.; Ahmed, Samiyah; Bostock, Mark J.; Guerot, Carine; Gohlke, Andrea; Kinzel, Olaf; Lamb, Michelle L.; Selmi, Nidhal; Stubbs, Christopher J.; Su, Nancy; Su, Qibin; Luo, Haiou; Xiong, Ting; Zuo, Xiaoqian; Bazzaz, Sana; Bienstock, Corey; Centrella, Paolo A.; Denton, Kyle E.; Gikunju, Diana; Guie, Marie-Aude; Guilinger, John P.; Hupp, Christopher; Keefe, Anthony D.; Satoh, Takashi; Zhang, Ying; Rivers, Emma L. 分享 收藏
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening Krieger, Inna V.; Yalamanchili, Subbarao; Dickson, Paige; Engelhart, Curtis A.; Zimmerman, Matthew D.; Wood, Jeremy; Clary, Ethan; Nguyen, Jasmine; Thornton, Natalie; Centrella, Paolo A.; Chan, Betty; Cuozzo, John W.; Gengenbacher, Martin; Guie, Marie-Aude; Guilinger, John P.; Bienstock, Corey; Hartl, Hajnalka; Hupp, Christopher D.; Jetson, Rachael; Satoh, Takashi; Yeoman, John T. S.; Zhang, Ying; Dartois, Veronique; Schnappinger, Dirk; Keefe, Anthony D.; Sacchettini, James C. 分享 收藏
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds Ramos, Ashley L.; Goedken, Eric R.; Frank, Kristine E.; Argiriadi, Maria A.; Bazzaz, Sana; Bian, Zhiguo; Brown, Jesse T. C.; Centrella, Paolo A.; Chen, Hui-Ju; Disch, Jeremy S.; Donner, Pamela L.; Duignan, David B.; Gikunju, Diana; Greszler, Stephen N.; Guie, Marie-Aude; Habeshian, Sevan; Hartl, Hajnalka E.; Hein, Christopher D.; Hutchins, Charles W.; Jetson, Rachael; Keefe, Anthony D.; Khan, Hasan; Li, Huan-Qiu; Olszewski, Allison; Ortiz Cardona, Benjamin J.; Osuma, Augustine; Panchal, Sanjay C.; Phelan, Ryan; Qiu, Wei; Shotwell, J. Brad; Shrestha, Anurupa; Srikumaran, Myron; Su, Zhi; Sun, Chaohong; Upadhyay, Anup K.; Wood, Michael D.; Wu, Haihong; Zhang, Ruijie; Zhang, Ying; Zhao, Gang; Zhu, Haizhong; Webster, Matthew P. 分享 收藏
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Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen 开发有效的Mcl-1抑制剂: 源自DNA编码的化学文库筛选的大环的结构研究 Hekking, Koen F. W.; Maroto, Sergio; van Kekem, Kees; Haasjes, Frank S.; Slootweg, Jack C.; Oude Alink, Patrick G. B.; Dirks, Ron; Sardana, Malvika; Bolster, Marjon G.; Kuijpers, Brian; Smith, Dennis; Doodeman, Robin; Scheepstra, Marcel; Zech, Birgit; Mulvihill, Mark; Renzetti, Louis M.; Babiss, Lee; Centrella, Paolo A.; Clark, Matthew A.; Cuozzo, John W.; Guie, Marie-Aude; Sigel, Eric; Habeshian, Sevan; Hupp, Christopher D.; Liu, Julie; Thomson, Heather A.; Zhang, Ying; Keefe, Anthony D.; Muller, Gerhard; Gremmen, Stijn 分享 收藏
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Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning Ahmad, Shabbir; Xu, Jin; Feng, Jianwen A.; Hutchinson, Ashley; Zeng, Hong; Ghiabi, Pegah; Dong, Aiping; Centrella, Paolo A.; Clark, Matthew A.; Guie, Marie-Aude; Guilinger, John P.; Keefe, Anthony D.; Zhang, Ying; Cerruti, Thomas; Cuozzo, John W.; von Rechenberg, Moritz; Bolotokova, Albina; Li, Yanjun; Loppnau, Peter; Seitova, Alma; Li, Yen-Yen; Santhakumar, Vijayaratnam; Brown, Peter J.; Ackloo, Suzanne; Halabelian, Levon 分享 收藏
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Discovery of new targeted protein degraders using DNA-encoded chemistry Keefe, Anthony D.; Disch, Jeremy S.; Duffy, Jennifer; Lee, Esther C.; Gikunju, Diana; Chan, Betty; Levin, Benjamin D.; Monteiro, Michael I.; Talcott, Sarah A.; Lau, Anthony; Zhou, Fei; Kozhushnyan, Anton; Westlund, Neil E.; Mullins, Patrick B.; Yu, Yan; Von Rechenberg, Moritz; Zhang, Junyi; Arnautova, Yelena; Liu, Yanbin; Zhang, Ying; McRiner, Andrew J.; Kohlmann, Anna; Clark, Matthew A.; Cuozzo, John W.; Huguet, Christelle; Arora, Shilpi 分享 收藏
Discovery of Nanomolar DCAF1 Small Molecule Ligands Li, Alice Shi Ming; Kimani, Serah; Wilson, Brian; Noureldin, Mahmoud; Gonzalez-Alvarez, Hector; Mamai, Ahmed; Hoffer, Laurent; Guilinger, John P.; Zhang, Ying; von Rechenberg, Moritz; Disch, Jeremy S.; Mulhern, Christopher J.; Slakman, Belinda L.; Cuozzo, John W.; Dong, Aiping; Poda, Gennady; Mohammed, Mohammed; Saraon, Punit; Mittal, Manish; Modh, Prati k; Rathod, Vaibhavi; Patel, Bhashant; Ackloo, Suzanne; Santhakumar, Vijayaratnam; Szewczyk, Magdalena M.; Barsyte-Lovejoy, Dalia; Arrowsmith, Cheryl H.; Marcellus, Richard; Guie, Marie-Aude; Keefe, Anthony D.; Brown, Peter J.; Halabelian, Levon; Al-awar, Rima; Vedadi, Masoud 分享 收藏
Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa Ryan, M. Dominic; Parkes, Alastair L.; Corbett, David; Dickie, Anthony P.; Southey, Michelle; Andersen, Ole A.; Stein, Daniel B.; Barbeau, Olivier R.; Sanzone, Angelo; Thommes, Pia; Barker, John; Cain, Ricky; Compper, Christel; Dejob, Magali; Dorali, Alain; Etheridge, Donnya; Evans, Sian; Faulkner, Adele; Gadouleau, Elise; Gorman, Timothy; Haase, Denes; Holbrow-Wilshaw, Maisie; Krulle, Thomas; Li, Xianfu; Lumley, Christopher; Mertins, Barbara; Napier, Spencer; Odedra, Rajesh; Papadopoulos, Kostas; Roumpelakis, Vasileios; Spear, Kate; Trimby, Emily; Williams, Jennifer; Zahn, Michael; Keefe, Anthony D.; Zhang, Ying; Soutter, Holly T.; Centrella, Paolo A.; Clark, Matthew A.; Cuozzo, John W.; Dumelin, Christoph E.; Deng, Boer; Hunt, Avery; Sigel, Eric A.; Troast, Dawn M.; DeJonge, Boudewijn L. M. 分享 收藏
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening Lee, Esther C. Y.; McRiner, Andrew J.; Georgiadis, Katy E.; Liu, Julie; Wang, Zooey; Ferguson, Andrew D.; Levin, Benjamin; von Rechenberg, Moritz; Hupp, Christopher D.; Monteiro, Michael, I; Keefe, Anthony D.; Olszewski, Allison; Eyermann, Charles J.; Centrella, Paolo; Liu, Yanbin; Arora, Shilpi; Cuozzo, John W.; Zhang, Ying; Clark, Matthew A.; Huguet, Christelle; Kohlmann, Anna 分享 收藏
Bispecific Estrogen Receptor a Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening 双特异性雌激素受体a降解剂结合了使用DNA编码的化学文库筛选鉴定的新型结合剂 Disch, Jeremy S.; Duffy, Jennifer M.; Lee, Esther C. Y.; Gikunju, Diana; Chan, Betty; Levin, Benjamin; Monteiro, Michael, I; Talcott, Sarah A.; Lau, Anthony C.; Zhou, Fei; Kozhushnyan, Anton; Westlund, Neil E.; Mullins, Patrick B.; Yu, Yan; von Rechenberg, Moritz; Zhang, Junyi; Arnautova, Yelena A.; Liu, Yanbin; Zhang, Ying; McRiner, Andrew J.; Keefe, Anthony D.; Kohlmann, Anna; Clark, Matthew A.; Cuozzo, John W.; Huguet, Christelle; Arora, Shilpi 分享 收藏
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy Nissink, J. Willem M.; Bazzaz, Sana; Blackett, Carolyn; Clark, Matthew A.; Collingwood, Olga; Disch, Jeremy S.; Gikunju, Diana; Goldberg, Kristin; Guilinger, John P.; Hardaker, Elizabeth; Hennessy, Edward J.; Jetson, Rachael; Keefe, Anthony D.; McCoull, William; McMurray, Lindsay; Olszewski, Allison; Overman, Ross; Pflug, Alexander; Preston, Marian; Rawlins, Philip B.; Rivers, Emma; Schimpl, Marianne; Smith, Paul; Truman, Caroline; Underwood, Elizabeth; Warwicker, Juli; Winter-Holt, Jon; Woodcock, Simon; Zhang, Ying 分享 收藏
Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors Veerman, Johan J. N.; Bruseker, Yorik B.; Damen, Eddy; Heijne, Erik H.; van Bruggen, Wendy; Hekking, Koen F. W.; Winkel, Rob; Hupp, Christopher D.; Keefe, Anthony D.; Liu, Julie; Thomson, Heather A.; Zhang, Ying; Cuozzo, John W.; McRiner, Andrew J.; Mulvihill, Mark J.; van Rijnsbergen, Peter; Zech, Birgit; Renzetti, Louis M.; Babiss, Lee; Muller, Gerhard 分享 收藏
Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry Cuozzo, John W.; Clark, Matthew A.; Keefe, Anthony D.; Kohlmann, Anna; Mulvihill, Mark; Ni, Haihong; Renzetti, Louis M.; Resnicow, Daniel, I; Ruebsam, Frank; Sigel, Eric A.; Thomson, Heather A.; Wang, Ce; Xie, Zhifeng; Zhang, Ying 分享 收藏
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