C.H. Arrowsmith - Publications, H-index & Citations

C.H. Arrowsmith

university of toronto

112H指数

3.1K论文数

4.3W被引数

收录论文 314

发表时间

Large-scale discovery, analysis and design of protein energy landscapes 大规模蛋白质能量景观的发现、分析与设计

Nature

IF48.5

2026-05-13

OAAI

Állan J. R. Ferrari; Sugyan M. Dixit; Jane Thibeault; Mario Garcia; Scott Houliston; Robert W. Ludwig; Pascal Notin; Claire M. Phoumyvong; Cydney M. Martell; Michelle D. Jung; Kotaro Tsuboyama; Lauren Carter; Cheryl H. Arrowsmith; Miklos Guttman; Gabriel J. Rocklin

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS)使用基于邻近的泛素位点鉴定技术（PrIUS）识别E3连接酶底物和PROTAC诱导的泛素化位点

Communications Biology

IF5.1

2026-04-09

OAAI

Tanner M. Tessier; Matthew E. R. Maitland; Maria Kutera; Joseph M. Dybas; Jonathan St-Germain; Cheryl H. Arrowsmith; Dalia Barsyte-Lovejoy; Wei Zhang; Brian Raught; Matthew D. Weitzman

A synergistic interaction between PRMT5 and LSD1 inhibitors in AML PRMT5与LSD1抑制剂的协同作用在AML中

Science Advances

IF12.5

2026-03-27

OAAI

Nesteene Joy Param; Elisa Arceci; Francesco Fiorentino; Luca Pignata; Denis Torre; Nayeli Gutiérrez-Trejo; Jia Yi Fong; Pierre-Alexis Goy; Brenda Y. Han; Chiara Lambona; Elisabetta Di Bello; Carola Castiello; Marco Barone; Megan Schwarz; Cheryl Arrowsmith; Koichi Ito; Peggy Scherle; Dave Keng Boon Wee; Steven Ndoye; Tommaso Tabaglio; Anand D. Jeyasekharan; Manikandan Lakshmanan; Roberto Cirilli; Hansjörg Habisch; Tobias Madl; Andrea Mattevi; Sergio Valente; Antonello Mai; Ernesto Guccione

Glioblastoma stem cells show transcriptionally correlated spatial organization 胶质母细胞瘤干细胞显示转录相关的空间组织

Communications Biology

IF5.1

2026-01-23

OAAI

Shamini Ayyadhury; Patty Sachamitr; Michelle M. Kushida; Nicole I. Park; Fiona J. Coutinho; Owen Whitley; Panagiotis Prinos; Cheryl H. Arrowsmith; Peter B. Dirks; Trevor J. Pugh; Gary D. Bader

Enantioselective protein affinity selection mass spectrometry (E-ASMS)手性蛋白质亲和选择质谱法 (E-ASMS)

Nature Communications

IF15.7

2025-12-17

OAAI

Xiaoyun Wang; Jianxian Sun; Shabbir Ahmad; Diwen Yang; Fengling Li; U. Hang Chan; Hong Zeng; Conrad V. Simoben; Stuart R. Green; Madhushika Silva; Scott Houliston; Aiping Dong; Albina Bolotokova; Elisa Gibson; Maria Kutera; Pegah Ghiabi; Ivan Kondratov; Tetiana Matviyuk; Alexander Chuprina; Danai Mavridi; Christopher Lenz; Andreas C. Joerger; Benjamin D. Brown; Richard B. Heath; Wyatt W. Yue; Lucy K. Robbie; Tyler S. Beyett; Susanne Müller; Stefan Knapp; Dafydd R. Owen; Rachel Harding; Matthieu Schapira; Peter J. Brown; Vijayaratnam Santhakumar; Suzanne Ackloo; Cheryl H. Arrowsmith; Aled M. Edwards; Hui Peng; Levon Halabelian

Nucleic acid nanorobot assay for accurate and simplified ASO quantification in mouse plasma 核酸纳米机器人检测方法用于小鼠血浆中ASO的准确且简化的定量分析

BIOANALYSIS

IF1.8

2025-12-01

PREAI

Sandelius, Asa; Arrowsmith, Cheryl; Henderson, Neil; Jackson, Alexander W.

A needed nomenclature for nucleosomes 核小体所需的命名法

Molecular Cell

IF16.6

2025-10-02

PREAI

Michael-Christopher Keogh; Genevieve Almouzni; Andrew J. Andrews; Karim-Jean Armache; Cheryl H. Arrowsmith; Sung Hee Baek; Mark T. Bedford; Emily Bernstein; Jacques Côté; Yael David; John M. Denu; Beat Fierz; Benjamin A. Garcia; Karen C. Glass; Or Gozani; Kristian Helin; Steven Henikoff; Ole N. Jensen; Steven Z. Josefowicz; Neil L. Kelleher; Tatiana G. Kutateladze; Herbert H. Lindner; Chao Lu; Karolin Luger; Parag Mallick; Catherine A. Musselman; Tom W. Muir; Ljiljana Paša-Tolić; Robert Schneider; Xiaobing Shi; Yang Shi; Simone Sidoli; Lloyd M. Smith; Jessica K. Tyler; Cynthia Wolberger; Jerry L. Workman; Brian D. Strahl; Nicolas L. Young

Site-Specific Hydrogen Deuterium Exchange Difference Mass Spectrometry Measurements for Ligand Binding 位点特异性氢氘交换差异质谱测量用于配体结合

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

IF2.7

2025-09-01

PREAI

Anacleto, Joseph; Ackloo, Suzanne; Arrowsmith, Cheryl; Wolf, Esther; Leblanc, Yves; Lento, Cristina; Wilson, Derek J.

OICR-41103 as a chemical probe for the DCAF1 WD40 domain OICR-41103 作为 DCAF1 WD40 结构域的化学探针

Communications Biology

IF5.1

2025-07-19

OAAI

Serah W. Kimani; Mahmoud Noureldin; Brian Wilson; Laurent Hoffer; Stuart R. Green; Magdalena M. Szewczyk; Héctor González-Álvarez; Mohammed Mohammed; Manuel Chan; Chiara Krausser; Alice Shi Ming Li; Taraneh Hajian; Sarah Tucker; Dhananjay Joshi; Punit Saraon; Brigitte Thériault; Ji Sup Kim; Vijayaratnam Santhakumar; Peter Loppnau; Yanjun Li; Almagul Seitova; Aiping Dong; Taira Kiyota; Tobias Hammann; Paul Gehrtz; Bhashant Patel; Vaibhavi Rathod; Anand Vala; Bhimsen Rout; Paras Jagodra; Peter J. Brown; Ahmed Aman; Jailall Ramnauth; Gennady Poda; David Uehling; Cheryl H. Arrowsmith; Dalia Barsyte-Lovejoy; Richard Marcellus; Suzanne Ackloo; Ahmed Mamai; Rima Al-awar; Levon Halabelian

Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity 手性选择性化学探针用于查加斯病毒nsP2解旋酶，并具有抗阿尔法病毒活性

ACS Infectious Diseases

IF3.8

2025-07-18

OAAI

Bose Muthu Ramalingam; Hans J. Oh; John D. Sears; Chun-Hsing Chen; Anand Vala; Shubin Liu; Kacey M. Talbot; Mohammed Anwar Hossain; Peter J. Brown; Scott Houliston; Julia Garcia Perez; Fengling Li; Meareg G. Amare; Peter Halfmann; Jessica L. Smith; Alec J. Hirsch; Cheryl H. Arrowsmith; Levon Halabelian; Ava Vargason; Rafael M. Couñago; Jamie J. Arnold; Craig E. Cameron; Nathaniel J. Moorman; Mark T. Heise; Timothy M. Willson

Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity 直接作用型nsP2解旋酶抑制剂的抗甲病毒活性鉴定

Journal of Medicinal Chemistry

IF6.8

2025-07-09

OAAI

Bose Muthu Ramalingam; John D. Sears; Kacey M. Talbot; Yuan-Wei Norman Su; Scott Houliston; Mohammed Anwar Hossain; Zachary W. Davis-Gilbert; Chunqing Zhao; Hans J. Oh; Peter J. Brown; Marcia K. Sanders; Stella R. Moorman; Durbadal Ojha; Jane E. Burdick; Isabella Law; Noah L. Morales; Sabian A. Martinez; Peter Loppnau; Julia Garcia Perez; Adam M. Drobish; Thomas E. Morrison; Zachary J. Streblow; Daniel N. Streblow; Cheryl H. Arrowsmith; Ava Vargason; Rafael M. Couñago; Levon Halabelian; Jamie J. Arnold; Craig E. Cameron; Nathaniel J. Moorman; Mark T. Heise; Timothy M. Willson

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities 基于模拟配体结合亲和力的主动学习引导的富含亮氨酸重复激酶2 WDR结构域命中优化

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2025-05-26

OAAI

Gusev, Filipp; Gutkin, Evgeny; Gentile, Francesco; Ban, Fuqiang; Koby, S. Benjamin; Li, Fengling; Chau, Irene; Ackloo, Suzanne; Arrowsmith, Cheryl H.; Bolotokova, Albina; Ghiabi, Pegah; Gibson, Elisa; Halabelian, Levon; Houliston, Scott; Harding, Rachel J.; Hutchinson, Ashley; Loppnau, Peter; Perveen, Sumera; Seitova, Almagul; Zeng, Hong; Schapira, Matthieu; Isayev, Olexandr; Kurnikova, Maria G.

PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents PRMT1 抑制剂 MS023 抑制 RNA 剪接以增强小细胞肺癌对 DNA 损伤剂的治疗敏感性

Neoplasia

IF7.7

2025-05-23

PREAI

Mansi K. Aparnathi; Sami Ul Haq; Jonathan St-Germain; Kevin C.J. Nixon; Joseph Walton; Lifang Song; Safa Majeed; Parasvi S. Patel; Ratheesh Subramaniam; Vivek Philip; Richard Marcellus; Dalia Barsyte-Lovejoy; Rima Al-Awar; Razqallah Hakem; Cheryl H. Arrowsmith; Laurie Ailles; Brian Raught; Benjamin H. Lok

PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites PRMT5通过抑制多个近端内含子多聚腺苷酸化位点来促进全长HTT的表达。

NUCLEIC ACIDS RESEARCH

IF13.1

2025-04-30

OAAI

Yadav, Manisha; AlQazzaz, Mona A.; Ciamponi, Felipe E.; Ho, Jolene C.; Maron, Maxim, I; Sababi, Aiden M.; MacLeod, Graham; Ahmadi, Moloud; Bullivant, Garrett; Tano, Vincent; Langley, Sarah R.; Sanchez-Osuna, Maria; Sachamitr, Patty; Kushida, Michelle; Bardile, Costanza Ferrari; Pouladi, Mahmoud A.; Kurtz, Rebecca; Richards, Laura; Pugh, Trevor; Tyers, Mike; Angers, Stephane; Dirks, Peter B.; Bader, Gary D.; Truant, Ray; Massirer, Katlin B.; Barsyte-Lovejoy, Dalia; Shechter, David; Harding, Rachel J.; Arrowsmith, Cheryl H.; Prinos, Panagiotis

The use of a multi-metric readout screen to identify EHMT2/G9a-inhibition as a modulator of cancer-associated fibroblast activation state 使用多度量读出屏幕来识别EHMT2/G9a-inhibition作为癌症相关成纤维细胞激活状态的调节剂

BIOMATERIALS

IF12.9

2025-03-01

PREAI

Wu, Nila C.; Quevedo, Rene; Nurse, Michelle; Hezaveh, Kebria; Liu, Haijiao; Sun, Fumao; Muffat, Julien; Sun, Yu; Simmons, Craig A.; Mcgaha, Tracy L.; Prinos, Panagiotis; Arrowsmith, Cheryl H.; Ailles, Laurie; D'Arcangelo, Elisa; Mcguigan, Alison P.

A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity 具有抗甲病毒活性和全蛋白质组选择性的基孔肯雅nsP2半胱氨酸蛋白酶的共价化学探针

SCIENTIFIC REPORTS

IF3.9

2025-03-01

OAAI

Ghoshal, Anirban; Tse, Edwin G.; Hossain, Mohammad Anwar; Asressu, Kesatebrhan Haile; Merten, Eric M.; Sears, John D.; Howell, Stefanie; Perveen, Sumera; Burdick, Jane; Morales, Noah L.; Martinez, Sabian A.; Law, Isabella; Davenport, Bennett J.; Morrison, Thomas E.; Streblow, Zachary J.; Streblow, Daniel N.; Mordant, Angie L.; Webb, Thomas S.; Cabrera, Aurora; Herring, Laura E.; Arrowsmith, Cheryl H.; Pearce, Kenneth H.; Moorman, Nathaniel J.; Heise, Mark T.; Counago, Rafael M.; Brown, Peter J.; Willson, Timothy M.

Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open 迈向目标2035: EUbOPEN-一个公私合作伙伴关系，以开放和解锁生物学

RSC MEDICINAL CHEMISTRY

IF3.6

2025-01-01

OAAI

Tredup, Claudia; Ackloo, Suzanne; Beck, Hartmut; Brown, Peter J.; Bullock, Alex N.; Ciulli, Alessio; Dikic, Ivan; Edfeldt, Kristina; Edwards, Aled M.; Elkins, Jonathan M.; Farin, Henner F.; Fon, Edward A.; Gstaiger, Matthias; Guenther, Judith; Gustavsson, Anna-Lena; Haeberle, Sandra; Isigkeit, Laura; Huber, Kilian V. M.; Kotschy, Andras; Kraemer, Oliver; Leach, Andrew R.; Marsden, Brian D.; Matsui, Hisanori; Merk, Daniel; Montel, Florian; Mulder, Monique P. C.; Mueller, Susanne; Owen, Dafydd R.; Proschak, Ewgenij; Roehm, Sandra; Stolz, Alexandra; Sundstroem, Michael; von Delft, Frank; Willson, Timothy M.; Arrowsmith, Cheryl H.; Knapp, Stefan

Thoughts for the future 对未来的思考

NATURE CHEMICAL BIOLOGY

IF13.7

2024-12-24

PREAI

Alkhalaf, Lona M.; Arrowsmith, Cheryl; Balskus, Emily P.; Bergamini, Giovanna; Bhandari, Rashna; Chang, Christopher J.; Chen, Peng; Chen, Xing; Ciulli, Alessio; Cricco, Julia A.; Davis, Benjamin G.; Delbianco, Martina; Dudareva, Natalia; Dueber, Erin; Ferguson, Fleur; de Giuseppe, Priscila Oliveira; Hamachi, Itaru; Hammond, Ming Chen; Hatzios, Stavroula K.; Do Heo, Won; Janet, Jon Paul; Kamat, Siddhesh S.; Knapp, Stefan; Krishnan, Yamuna; Lang, Kathrin; Laraia, Luca; Leveson-Gower, Reuben B.; Li, Xiang David; Liu, David R.; Liu, Mo-Fang; London, Nir; Mahanta, Nilkamal; Mayor-Ruiz, Cristina; Muir, Tom; Murakami, Mario Tyago; Rhee, Hyun-Woo; Robers, Matt; Satz, Alex; Schulman, Brenda A.; Shen, Ben; Shoichet, Brian; Strauss, Erick; Suzuki, Tsutomu; Tiwary, Pratyush; Waldmann, Herbert; Ward, Thomas R.; Weeks, Amy; Weerapana, Eranthie; Winter, Georg

Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex Β-螺旋桨亚基WDR26和muskelin之间的相互作用调节CTLH E3连接酶超分子复合物

COMMUNICATIONS BIOLOGY

IF5.1

2024-12-19

OAAI

Maitland, Matthew E. R.; Onea, Gabriel; Owens, Dominic D. G.; Gonga-Cave, Brianna C.; Wang, Xu; Arrowsmith, Cheryl H.; Barsyte-Lovejoy, Dalia; Lajoie, Gilles A.; Schild-Poulter, Caroline

Discovery of CHD1 Antagonists for PTEN-Deficient Prostate Cancer PTEN缺陷型前列腺癌的CHD1拮抗剂的发现

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-11-07

PREAI

Johnson, Rebecca L.; Graboski, Amanda L.; Li, Fengling; Norris-Drouin, Jacqueline L.; Walton, William G.; Arrowsmith, Cheryl H.; Redinbo, Matthew R.; Frye, Stephen V.; James, Lindsey I.

研究方向