Artis Klapars - Publications, H-index & Citations

Artis Klapars

Merck & Co., Inc.

33H指数

85论文数

7.7K被引数

收录论文 45

发表时间

Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide 生物催化级联实现大环肽enlicitide的制造

Science

IF45.8

2026-05-07

PREAI

Artis Klapars; Anna Fryszkowska; Stephanie Galanie; Omer Ad; Ellen Y. Aguilera; Nnamdi Akporji; Chihui An; Stephanus Axnanda; Tewoderos M. Ayele; Richard S. Ayikpoe; Rodell C. Barrientos; Matthew R. Bauerle; Marc R. Becker; Kevin M. Belyk; Lisa Bereznitski; Jackson K. B. Cahn; Karla Camacho Soto; Louis-Charles Campeau; Kevin R. Campos; Anagha Chandra; Hsieh Yao Darryl Chang; Mengbin Chen; Zhiwei Chen; Wai Ling Cheung-Lee; Cheol K. Chung; Stephanie W. Chun; Sarah S. Co; Ryan D. Cohen; Stephen M. Dalby; Guilherme Dal Poggetto; Truc Do; Spencer D. Dreher; Riki J. Drout; Noah P. Dunham; Yi Fan; Ryan M. Flessner; Jacob H. Forstater; Scott P. France; Janaka C. Gamekkanda; Donald R. Gauthier; Agnieszka A. Gil; Jacob W. Greenwood; Noel Ha; Holst M. Halsey; Xinxin Han; Michael Hartmann; Clara Hartmanshenn; Yu He; Edgar Hernandez; Kaori Hiraga; Hsing-I Ho; Cynthia M. Hong; Alan Hruza; Hang Hu; Kari Hullen; Alan M. Hyde; Tetsuji Itoh; Chey M. Jones; Woo-Ok Jung; Kanan Kanuga; James Levi Knippel; Joshua N. Kolev; Jongrock Kong; Birgit Kosjek; Sara Koynov; Michael H. Kress; Bharath Krishnamurthi; Jeffrey T. Kuethe; Thomas T. Kwok; Alfred Y. Lee; Joshua Lee; Qiuhan Li; Shasha Li; Jing Liao; Wenjun Liu; Gurpreet Longia; Emma Madrigal; Peter E. Maligres; Kevin M. Maloney; Erin L. McCarthy; John A. McIntosh; Samaneh Mesbahi-Vasey; Margaret Miller; Mansi Modi; Jeffrey C. Moore; Debopreeti Mukherjee; Grant S. Murphy; Jennifer Victoriano Obligacion; Weilan Pan; Julia Parzecki; Anisha Patel; Teng Peng; Byron K. Peters; Tiffany Piou; Carlos A. Pons Siepermann; Christopher K. Prier; Akasha K. Purohit; Yangzhong Qin; Erik L. Regalado; Mikhail Reibarkh; Nelo R. Rivera; Sandra A. Robaire; Lee Robison; Syamantak Roy; Rebecca T. Ruck; Katie A. Rykaczewski; Christopher H. Schuster; Erica L. Schwalm; Andrew N. Singh; Eric Sirota; Alexandra C. Sun; Weijuan Tang; David A. Thaisrivongs; Nimisha Thakur; Weidong Tong; Van Truong; Ryan Tsoi; Qiang Tu; Ben W. H. Turnbull; Ophelia Ukaegbu; David A. Vargas; Juan E. Velasquez; Deeptak Verma; Heather Wang; Tao Wang; Xiao Wang; Ying Wang; Zhixun Wang; Matthew S. Winston; Chunyu Wu; Brian M. Wyvratt; Kai-Jiong Xiao; Yingju Xu; Jia-Xuan Yan; Hao Yang; Victoria Zhang; Yongqian Zhang; Michelle Zheng; Wendy Zhong

Total Synthesis of Enlicitide Decanoate 恩利西肽癸酸酯的全合成

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2025-03-24

PREAI

Li, Hongming; Thaisrivongs, David A.; Shang, Gao; Chen, Yonggang; Chen, Qinghao; Tan, Lushi; Xiao, Kai-Jiong; Larson, Reed T.; Kuethe, Jeffrey T.; Lee, Joshua; Deprez, Nicholas R.; Nolting, Andrew F.; Poirier, Marc; Bulger, Paul G.; Regalado, Erik L.; Biba, Mirlinda; Tsay, Fuh-Rong; Dasilva, Jimmy; Prier, Chris K.; Strulson, Christopher A.; Zawatzky, Kerstin; Liu, Zhu; Newman, Justin A.; Sokolowsky, Kathleen; Tang, Weijuan; Hullen, Kari; Thakur, Nimisha; Welch, Cody; Patel, Smit; He, Yu; Xu, Jing; Variankaval, Narayan; Klapars, Artis; Kong, Jongrock; Desmond, Richard; Varsolona, Richard; Maligres, Peter E.; Siepermann, Carlos A. Pons; Robison, Lee; Piou, Tiffany; Hartmanshenn, Clara; Chandra, Anagha; Patel, Anisha; Becker, Marc R.; Liu, Guiquan; Duan, Jianjun; Wan, Baoqiang; Xiao, Chengqian; Yuan, Yongpeng; Cao, Xiaohui; Chen, Lu; Yi, Ruxia; Wu, Zheng; Feng, Minyi; Li, Donghong; Song, Zhiyan; Dong, Yawei; Sun, Julin; Li, Biao; Shao, Guangxin; Campeau, Louis-Charles; Yin, Jingjun

Development of a Thiophosphorylation Process for the Synthesis of 2′F-Thio-Adenosine Monophosphate

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-02-05

PREAI

Obligacion, Jennifer V.; Wang, Tao; Kwok, Thomas T.; Zewge, Daniel; Cohen, Ryan D.; Reibarkh, Mikhail; Klapars, Artis; Zawatzky, Kerstin; Axnanda, Stephanus; Liu, Zhu; Dance, Zachary E. X.; Smith, Joseph P.; Zhong, Wendy; Wang, Heather; Chung, Cheol K.; Salehi Marzijarani, Nastaran; Liu, Zhijian

Manufacturing Process Development for Uprifosbuvir (MK-3682): A Green and Sustainable Process for Preparing Penultimate 2′-Deoxy-α-2′-Chloro-β-2′-Methyluridine

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2022-08-16

PREAI

Maligres, Peter E.; Peng, Feng; Calabria, Ralph; Campeau, Louis-Charles; Chen, Wenyong; Dormer, Peter G.; Green, Meredith; He, Cyndi Qixin; Hyde, Alan M.; Klapars, Artis; Larsen, Mona Utne; Limanto, John; Liu, Guiquan; Liu, Yizhou; Moment, Aaron; Nowak, Timothy; Ruck, Rebecca T.; Shevlin, Michael; Song, Zhiguo Jake; Tan, Lushi; Tong, Weidong; Waldman, Jacob H.; Ye, Honglin; Zhao, Ralph; Zhou, George; Zompa, Michael A.; Zultanski, Susan L.

Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

ACS CENTRAL SCIENCE

IF10.4

2021-10-29

109

OAAI

McIntosh, John A.; Benkovics, Tamas; Silverman, Steven M.; Huffman, Mark A.; Kong, Jongrock; Maligres, Peter E.; Itoh, Tetsuji; Yang, Hao; Verma, Deeptak; Pan, Weilan; Ho, Hsing-, I; Vroom, Jonathan; Knight, Anders M.; Hurtak, Jessica A.; Klapars, Artis; Fryszkowska, Anna; Morris, William J.; Strotman, Neil A.; Murphy, Grant S.; Maloney, Kevin M.; Fier, Patrick S.

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor 通过标准化的微型反应器释放电化学的高通量实验的潜力

ACS CENTRAL SCIENCE

IF10.4

2021-08-05

OAAI

Rein, Jonas; Annand, James R.; Wismer, Michael K.; Fu, Jiantao; Siu, Juno C.; Klapars, Artis; Strotman, Neil A.; Kalyani, Dipannita; Lehnherr, Dan; Lin, Song

Electrochemical Activation of Galactose Oxidase: Mechanistic Studies and Synthetic Applications 半乳糖氧化酶的电化学活化: 机理研究和合成应用

ACS CATALYSIS

IF13.1

2021-06-04

PREAI

Zhang, Shaoguang; Ruccolo, Serge; Fryszkowska, Anna; Klapars, Artis; Marshall, Nicholas; Strotman, Neil A.

Metal-Free Electrochemical Synthesis of Sulfonamides Directly from (Hetero)arenes, SO2, and Amines

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2021-02-02

OAAI

Blum, Stephan P.; Karakaya, Tarik; Schollmeyer, Dieter; Klapars, Artis; Waldvogel, Siegfried R.

Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods

CHEMICAL SCIENCE

IF7.4

2021-01-01

OAAI

Klapars, Artis; Chung, John Y. L.; Limanto, John; Calabria, Ralph; Campeau, Louis-Charles; Campos, Kevin R.; Chen, Wenyong; Dalby, Stephen M.; Davis, Tyler A.; DiRocco, Daniel A.; Hyde, Alan M.; Kassim, Amude M.; Larsen, Mona Utne; Liu, Guiquan; Maligres, Peter E.; Moment, Aaron; Peng, Feng; Ruck, Rebecca T.; Shevlin, Michael; Simmons, Bryon L.; Song, Zhiguo Jake; Tan, Lushi; Wright, Timothy J.; Zultanski, Susan L.

Development and Implementation of an Aluminum-Promoted Phosphorylation in the Uprifosbuvir Manufacturing Route

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-12-07

PREAI

Liu, Zhuqing; Klapars, Artis; Simmons, Bryon; Bellomo, Ana; Kalinin, Alexei; Weisel, Mark; Hill, Jerry; Silverman, Steven M.

New Mechanism for Cinchona Alkaloid-Catalysis Allows for an Efficient Thiophosphorylation Reaction

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2020-11-12

PREAI

Marzijarani, Nastaran Salehi; Lam, Yu-hong; Wang, Xiao; Klapars, Artis; Qi, Ji; Song, Zhiyan; Sherry, Benjamin D.; Liu, Zhijian; Ji, Yining

Mechanistic Understanding of a Robust and Scalable Synthesis of Per(6-deoxy-6-halo)cyclodextrins, Versatile Intermediates for Cyclodextrin Modification

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-09-10

PREAI

Zultanski, Susan L.; Kuhl, Nadine; Zhong, Wendy; Cohen, Ryan D.; Reibarkh, Mikhail; Jurica, Jon; Kim, Jungchul; Weisel, Lauren; Ekkati, Anil R.; Klapars, Artis; Gauthier, Donald R., Jr.; Dunn, Jamie M. McCabe

Investigating the Underappreciated Hydrolytic Instability of 1,8-Diazabicyclo[5.4.0]undec-7-ene and Related Unsaturated Nitrogenous Bases

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2019-07-11

PREAI

Hyde, Alan M.; Calabria, Ralph; Arvary, Rebecca; Wang, Xiao; Klapars, Artis

Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances

ANALYST

IF3.3

2019-01-01

PREAI

Ahmad, Imad A. Haidar; Chen, Wenyong; Halsey, Holst M.; Klapars, Artis; Limanto, John; Pirrone, Gregory F.; Nowak, Timothy; Bennett, Raffeal; Hartman, Robert; Makarov, Alexey A.; Mangion, Ian; Regalado, Erik L.

Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189

ORGANIC LETTERS

IF5

2017-04-18

PREAI

Simmons, Bryon; Liu, Zhuqing; Klapars, Artis; Bellomo, Ana; Silverman, Steven M.

Impact of Lead Impurities in Zinc Dust on the Selective Reduction of a Dibromoimidazole Derivative

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2016-12-16

PREAI

Yin, Jianguo; Maguire, Courtney K.; Yasuda, Nobuyoshi; Brunskill, Andrew P. J.; Klapars, Artis

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction

ORGANIC LETTERS

IF5

2016-11-01

PREAI

Hyde, Alan M.; Liu, Zhijian; Kosjek, Birgit; Tan, Lushi; Klapars, Artis; Ashley, Eric It; Zhong, Yong-Li; Alvizo, Oscar; Agard, Nicholas J.; Liu, Guiquan; Gu, Xiuyan; Yasuda, Nobuyoshi; Limanto, John; Huffman, Mark K.; Tschaen, David M.

Asymmetric Synthesis of N-Boc-(R)-Silaproline via Rh-Catalyzed Intramolecular Hydrosilylation of Dehydroalanine and Continuous Flow N-Alkylation

ORGANIC LETTERS

IF5

2016-03-25

PREAI

Chung, John Y. L.; Shevlin, Michael; Klapars, Artis; Journet, Michel

Evaluation and Control of Mutagenic Impurities in a Development Compound: Purge Factor Estimates vs Measured Amounts

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2015-10-14

PREAI

McLaughlin, Mark; Dermenjian, Renee K.; Jin, Yan; Klapars, Artis; Reddy, M. Vijayaraj; Williams, Michael J.

Enantioselective Synthesis of an HCV NS5a Antagonist

ORGANIC LETTERS

IF5

2014-04-11

PREAI

Mangion, Ian K.; Chen, Cheng-yi; Li, Hongmei; Maligres, Peter; Chen, Yonggang; Christensen, Melodie; Cohen, Ryan; Jeon, Ingyu; Klapars, Artis; Krska, Shane; Hoa Nguyen; Reamer, Robert A.; Sherry, Benjamin D.; Zavialov, Ilia

研究方向