Spencer D. Dreher - Publications, H-index & Citations

Spencer D. Dreher

Merck & Co., Inc.

38H指数

93论文数

8.0K被引数

收录论文 43

发表时间

Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide 生物催化级联实现大环肽enlicitide的制造

Science

IF45.8

2026-05-07

PREAI

Artis Klapars; Anna Fryszkowska; Stephanie Galanie; Omer Ad; Ellen Y. Aguilera; Nnamdi Akporji; Chihui An; Stephanus Axnanda; Tewoderos M. Ayele; Richard S. Ayikpoe; Rodell C. Barrientos; Matthew R. Bauerle; Marc R. Becker; Kevin M. Belyk; Lisa Bereznitski; Jackson K. B. Cahn; Karla Camacho Soto; Louis-Charles Campeau; Kevin R. Campos; Anagha Chandra; Hsieh Yao Darryl Chang; Mengbin Chen; Zhiwei Chen; Wai Ling Cheung-Lee; Cheol K. Chung; Stephanie W. Chun; Sarah S. Co; Ryan D. Cohen; Stephen M. Dalby; Guilherme Dal Poggetto; Truc Do; Spencer D. Dreher; Riki J. Drout; Noah P. Dunham; Yi Fan; Ryan M. Flessner; Jacob H. Forstater; Scott P. France; Janaka C. Gamekkanda; Donald R. Gauthier; Agnieszka A. Gil; Jacob W. Greenwood; Noel Ha; Holst M. Halsey; Xinxin Han; Michael Hartmann; Clara Hartmanshenn; Yu He; Edgar Hernandez; Kaori Hiraga; Hsing-I Ho; Cynthia M. Hong; Alan Hruza; Hang Hu; Kari Hullen; Alan M. Hyde; Tetsuji Itoh; Chey M. Jones; Woo-Ok Jung; Kanan Kanuga; James Levi Knippel; Joshua N. Kolev; Jongrock Kong; Birgit Kosjek; Sara Koynov; Michael H. Kress; Bharath Krishnamurthi; Jeffrey T. Kuethe; Thomas T. Kwok; Alfred Y. Lee; Joshua Lee; Qiuhan Li; Shasha Li; Jing Liao; Wenjun Liu; Gurpreet Longia; Emma Madrigal; Peter E. Maligres; Kevin M. Maloney; Erin L. McCarthy; John A. McIntosh; Samaneh Mesbahi-Vasey; Margaret Miller; Mansi Modi; Jeffrey C. Moore; Debopreeti Mukherjee; Grant S. Murphy; Jennifer Victoriano Obligacion; Weilan Pan; Julia Parzecki; Anisha Patel; Teng Peng; Byron K. Peters; Tiffany Piou; Carlos A. Pons Siepermann; Christopher K. Prier; Akasha K. Purohit; Yangzhong Qin; Erik L. Regalado; Mikhail Reibarkh; Nelo R. Rivera; Sandra A. Robaire; Lee Robison; Syamantak Roy; Rebecca T. Ruck; Katie A. Rykaczewski; Christopher H. Schuster; Erica L. Schwalm; Andrew N. Singh; Eric Sirota; Alexandra C. Sun; Weijuan Tang; David A. Thaisrivongs; Nimisha Thakur; Weidong Tong; Van Truong; Ryan Tsoi; Qiang Tu; Ben W. H. Turnbull; Ophelia Ukaegbu; David A. Vargas; Juan E. Velasquez; Deeptak Verma; Heather Wang; Tao Wang; Xiao Wang; Ying Wang; Zhixun Wang; Matthew S. Winston; Chunyu Wu; Brian M. Wyvratt; Kai-Jiong Xiao; Yingju Xu; Jia-Xuan Yan; Hao Yang; Victoria Zhang; Yongqian Zhang; Michelle Zheng; Wendy Zhong

Cu Oxamate-Promoted Cross-Coupling of α-Branched Amines and Complex Aryl Halides: Investigating Ligand Function through Data Science

ACS CATALYSIS

IF13.1

2023-12-05

PREAI

Matthews, Adrian D.; Peters, Ellyn; Debenham, John S.; Gao, Qi; Nyamiaka, Maya D.; Pan, Jianping; Zhang, Li-Kang; Dreher, Spencer D.; Krska, Shane W.; Sigman, Matthew S.; Uehling, Mycah R.

Miniaturization of popular reactions from the medicinal chemists' toolbox for ultrahigh-throughput experimentation

NATURE SYNTHESIS

IF20

2023-06-22

PREAI

Gesmundo, Nathan; Dykstra, Kevin; Douthwaite, James L.; Kao, Yu-Ting; Zhao, Ruheng; Mahjour, Babak; Ferguson, Ron; Dreher, Spencer; Sauvagnat, Berengere; Sauri, Josep; Cernak, Tim

Development of a high intensity parallel photoreactor for high throughput screening

REACTION CHEMISTRY & ENGINEERING

IF3.1

2022-01-01

PREAI

Qi, Ning; Wismer, Michael K.; Conway, Donald, V; Krska, Shane W.; Dreher, Spencer D.; Lin, Shishi

The Open Reaction Database 开放的反应数据库

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2021-11-02

152

OAAI

Kearnes, Steven M.; Maser, Michael R.; Wleklinski, Michael; Kast, Anton; Doyle, Abigail G.; Dreher, Spencer D.; Hawkins, Joel M.; Jensen, Klavs F.; Coley, Connor W.

Chemistry Informer Libraries: Conception, Early Experience, and Role in the Future of Cheminformatics

ACCOUNTS OF CHEMICAL RESEARCH

IF17.7

2021-03-16

PREAI

Dreher, Spencer D.; Krska, Shane W.

Excellence in Industrial Organic Synthesis 2019: The Past, Present, and Future

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2019-04-19

OAAI

Ragan, John A.; Dreher, Spencer D.

Catalysis in medicinal chemistry

REACTION CHEMISTRY & ENGINEERING

IF3.1

2019-01-01

PREAI

Dreher, Spencer D.

Response to Comment on Predicting reaction performance in C-N cross-coupling using machine learning

SCIENCE

IF45.8

2018-11-16

188

OAAI

Estrada, Jesus G.; Ahneman, Derek T.; Sheridan, Robert P.; Dreher, Spencer D.; Doyle, Abigail G.

The Evolution of Chemical High-Throughput Experimentation To Address Challenging Problems in Pharmaceutical Synthesis

ACCOUNTS OF CHEMICAL RESEARCH

IF17.7

2017-11-27

242

PREAI

Krska, Shane W.; DiRocco, Daniel A.; Dreher, Spencer D.; Shevlin, Michael

Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational Study 钯催化的芳基次磺酸根阴离子的对映选择性芳基化: 实验和计算的结合研究

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2017-06-07

OAAI

Jia, Tiezheng; Zhang, Mengnan; McCollom, Samuel P.; Bellomo, Ana; Montel, Sonia; Mao, Jianyou; Dreher, Spencer D.; Welch, Christopher J.; Regalado, Erik L.; Williamson, R. Thomas; Manor, Brian C.; Tomson, Neil C.; Walsh, Patrick J.

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-03-02

PREAI

Cernak, Tim; Gesmundo, Nathan J.; Dykstra, Kevin; Yu, Yang; Wu, Zhicai; Shi, Zhi-Cai; Vachal, Petr; Sperbeck, Donald; He, Shuwen; Murphy, Beth Ann; Sonatore, Lisa; Williams, Steven; Madeira, Maria; Verras, Andreas; Reiter, Maud; Lee, Claire Heechoon; Cuff, James; Sherer, Edward C.; Kuethe, Jeffrey; Goble, Stephen; Perrotto, Nicholas; Pinto, Shirly; Shen, Dong-Ming; Nargund, Ravi; Balkovec, James; DeVita, Robert J.; Dreher, Spencer D.

Selective functionalization of complex heterocycles via an automated strong base screening platform

REACTION CHEMISTRY & ENGINEERING

IF3.1

2017-01-01

PREAI

Boga, Sobhana Babu; Christensen, Melodie; Perrotto, Nicholas; Krska, Shane W.; Dreher, Spencer; Tudge, Matthew T.; Ashley, Eric R.; Poirier, Marc; Reibarkh, Mikhail; Liu, Yong; Streckfuss, Eric; Campeau, Louis-Charles; Ruck, Rebecca T.; Davies, Ian W.; Vachal, Petr

Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents 通过使用高度功能化的工作台稳定的有机锌试剂合成复杂的药物样分子

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2016-09-30

PREAI

Greshock, Thomas J.; Moore, Keith P.; McClain, Ray T.; Bellomo, Ana; Chung, Cheol K.; Dreher, Spencer D.; Kutchukian, Peter S.; Peng, Zhengwei; Davies, Ian W.; Vachal, Petr; Ellwart, Mario; Manolikakes, Sophia M.; Knochel, Paul; Nantermet, Philippe G.

Process Development of the HCV NS5B Site D Inhibitor MK-8876

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2016-07-01

PREAI

Williams, Michael J.; Chen, Qinghao; Codan, Lorenzo; Dermenjian, Renee K.; Dreher, Spencer; Gibson, Andrew W.; He, Xianliang; Jin, Yan; Keen, Stephen P.; Lee, Alfred Y.; Lieberman, David R.; Lin, Wei; Liu, Guiquan; McLaughlin, Mark; Reibarkh, Mikhail; Scott, Jeremy P.; Strickfuss, Sophie; Tan, Lushi; Varsolona, Richard J.; Wen, Feng

Palladium-Catalyzed Asymmetric Allylic Alkylations with Toluene Derivatives as Pronucleophiles

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2016-01-12

OAAI

Mao, Jianyou; Zhang, Jiadi; Jiang, Hui; Bellomo, Ana; Zhang, Mengnan; Gao, Zidong; Dreher, Spencer D.; Walsh, Patrick J.

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods 化学线人库: 一种基于化学信息学的方法来评估和推进合成方法

CHEMICAL SCIENCE

IF7.4

2016-01-01

177

OAAI

Kutchukian, Peter S.; Dropinski, James F.; Dykstra, Kevin D.; Li, Bing; DiRocco, Daniel A.; Streckfuss, Eric C.; Campeau, Louis-Charles; Cernak, Tim; Vachal, Petr; Davies, Ian W.; Krska, Shane W.; Dreher, Spencer D.

P2Et Phosphazene: A Mild, Functional Group Tolerant Base for Soluble, Room Temperature Pd-Catalyzed C-N, C-O, and C-C Cross-Coupling Reactions

ORGANIC LETTERS

IF5

2015-06-22

PREAI

Santanilla, Alexander Buitrago; Christensen, Melodie; Campeau, Louis-Charles; Davies, Ian W.; Dreher, Spencer D.

NiXantphos: A Deprotonatable Ligand for Room-Temperature Palladium-Catalyzed Cross-Couplings of Aryl Chlorides

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2014-04-21

154

OAAI

Zhang, Jiadi; Bellomo, Ana; Trongsiriwat, Nisalak; Jia, Tiezheng; Carroll, Patrick J.; Dreher, Spencer D.; Tudge, Matthew T.; Yin, Haolin; Robinson, Jerome R.; Schelter, Eric J.; Walsh, Patrick J.

Development of a Practical, Asymmetric Synthesis of the Hepatitis C Virus Protease Inhibitor MK-5172

ORGANIC LETTERS

IF5

2013-08-06

PREAI

Kuethe, Jeffrey; Zhong, Yong-Li; Yasuda, Nobuyoshi; Beutner, Gregory; Linn, Katherine; Kim, Mary; Marcune, Benjamin; Dreher, Spencer Douglas; Humphrey, Guy; Pei, Tao

研究方向