D. Grahame Hardie - Publications, H-index & Citations

D. Grahame Hardie

University of Dundee

140H指数

643论文数

8.8W被引数

收录论文 187

发表时间

AMPK: a master regulator of mitochondrial quality and quantity AMPK：线粒体质量和数量的主调控因子

Trends in Cell Biology

IF18.1

2026-05-12

OAAI

Reuben J. Shaw; Ian G. Ganley; Julien Prudent; D. Grahame Hardie

AMPK associates with and causes fragmentation of the Golgi by phosphorylating the guanine nucleotide exchange factor GBF1 AMPK通过磷酸化鸟嘌呤核苷酸交换因子GBF1与高尔基体相关并导致其断裂

JOURNAL OF CELL SCIENCE

IF3.6

2024-12-23

OAAI

Freemantle, Jordana B.; Towler, Mhairi C.; Hudson, Emma R.; Macartney, Thomas; Zwirek, Monika; Liu, David J. K.; Pan, David A.; Ponnambalam, Sreenivasan; Hardie, D. Grahame

The thienopyridine A-769662 and benzimidazole 991 inhibit human TASK-3 potassium channels in an AMPK-independent manner

BIOCHEMICAL PHARMACOLOGY

IF5.6

2024-12-01

PREAI

Said, Esraa A.; Lewis, Ryan W.; Dallas, Mark L.; Peers, Chris; Ross, Fiona A.; Unciti-Broceta, Asier; Hardie, D. Grahame; Evans, A. Mark

The pro-drug C13 activates AMPK by two distinct mechanisms

BIOCHEMICAL JOURNAL

IF4.3

2024-09-12

OAAI

Freemantle, Jordana B.; Shah, Dinesh; Lynch, Dylan M.; Ciulli, Alessio; Hundal, Harinder S.; Hardie, D. Grahame

CDK4 Phosphorylates AMPKα2 to Inhibit Its Activity and Repress Fatty Acid Oxidation (vol 68, pg 336, 2017)

MOLECULAR CELL

IF16.6

2024-06-01

OAAI

Lopez-Mejia, Isabel C.; Lagarrigue, Sylviane; Giralt, Albert; Martinez-Carreres, Laia; Martin, Javier; Ortega, Sagrario; Zanou, Nadege; Denechaud, Pierre-Damien; Castillo-Armengol, Judit; Chavey, Carine; Orpinell, Meritxell; Delacuisine, Brigitte; Nasrallah, Anita; Collodet, Caterina; Zhang, Lianjun; Viollet, Benoit; Hardie, D. Grahame; Fajas, Lluis

AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand

BIOCHEMICAL JOURNAL

IF4.3

2024-04-22

OAAI

Hawley, Simon A.; Russell, Fiona M.; Hardie, D. Grahame

Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo

NATURE COMMUNICATIONS

IF15.7

2024-03-08

OAAI

Virga, Daniel M.; Hamilton, Stevie; Osei, Bertha; Morgan, Abigail; Kneis, Parker; Zamponi, Emiliano; Park, Natalie J.; Hewitt, Victoria L.; Zhang, David; Gonzalez, Kevin C.; Russell, Fiona M.; Hardie, D. Grahame; Prudent, Julien; Bloss, Erik; Losonczy, Attila; Polleux, Franck; Lewis Jr, Tommy L.

Frequent loss-of-function mutations in the AMPK- α2 catalytic subunit suggest a tumour suppressor role in human skin cancers

BIOCHEMICAL JOURNAL

IF4.3

2023-12-01

OAAI

Ross, Fiona A.; Hawley, Simon A.; Russell, Fiona M.; Goodman, Nicola; Hardie, D. Grahame

AMP-activated kinase regulates cytoplasmic HuR

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

221

OAAI

Wang, W; Fan, J; Yang, X; Fürer-Galban, S; de Silanes, IL; von Kobbe, C; Guo, J; Georas, SN; Foufelle, F; Hardie, DG; Carling, D; Gorospe, M

100 years of the Warburg effect: a historical perspective

ENDOCRINE-RELATED CANCER

IF4.6

2022-12-01

OAAI

Hardie, D. Grahame

AMP-activated protein kinase - a journey from 1 to 100 downstream targets

BIOCHEMICAL JOURNAL

IF4.3

2022-11-16

OAAI

Hardie, D. Grahame

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology AMPK依赖的MTFR1L磷酸化调控线粒体形态

SCIENCE ADVANCES

IF12.5

2022-11-11

OAAI

Tilokani, Lisa; Russell, Fiona M.; Hamilton, Stevie; Virga, Daniel M.; Segawa, Mayuko; Paupe, Vincent; V. Gruszczyk, Anja; Protasoni, Margherita; Tabara, Luis -Carlos; Johnson, Mark; Anand, Hanish; Murphy, Michael P.; Hardie, D. Grahame; Polleux, Franck; Prudent, Julien

New insights into activation and function of the AMPK 对AMPK的激活和功能的新见解

NATURE REVIEWS MOLECULAR CELL BIOLOGY

IF90.2

2022-10-31

316

PREAI

Steinberg, Gregory R.; Hardie, D. Grahame

LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response (vol 5, 642, 2022)

COMMUNICATIONS BIOLOGY

IF5.1

2022-07-29

OAAI

MacMillan, Sandy; Holmes, Andrew P.; Dallas, Mark L.; Mahmoud, Amira D.; Shipston, Michael J.; Peers, Chris; Hardie, D. Grahame; Kumar, Prem; Evans, A. Mark

LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response

COMMUNICATIONS BIOLOGY

IF5.1

2022-06-29

OAAI

MacMillan, Sandy; Holmes, Andrew P.; Dallas, Mark L.; Mahmoud, Amira D.; Shipston, Michael J.; Peers, Chris; Hardie, D. Grahame; Kumar, Prem; Evans, A. Mark

Caspase cleavage and nuclear retention of the energy sensor AMPK-a1 during apoptosis 凋亡过程中能量传感器AMPK-a1的半胱天冬酶裂解和核保留

CELL REPORTS

IF6.9

2022-05-01

OAAI

Cheratta, Anees Rahman; Thayyullathil, Faisal; Hawley, Simon A.; Ross, Fiona A.; Atrih, Abdelmajdid; Lamont, Douglas J.; Pallichankandy, Siraj; Subburayan, Karthikeyan; Alakkal, Ameer; Rezgui, Rachid; Gray, Alex; Hardie, D. Grahame; Galadari, Sehamuddin

Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy 线粒体定位的AMPK对局部能量有反应，并有助于运动和能量应激诱导的线粒体自噬

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-09-07

110

OAAI

Drake, Joshua C.; Wilson, Rebecca J.; Laker, Rhianna C.; Guan, Yuntian; Spaulding, Hannah R.; Nichenko, Anna S.; Shen, Wenqing; Shang, Huayu; Dorn, Maya, V; Huang, Kian; Zhang, Mei; Bandara, Aloka B.; Brisendine, Matthew H.; Kashatus, Jennifer A.; Sharma, Poonam R.; Young, Alexander; Gautam, Jitendra; Cao, Ruofan; Wallrabe, Horst; Chang, Paul A.; Wong, Michael; Desjardins, Eric M.; Hawley, Simon A.; Christ, George J.; Kashatus, David F.; Miller, Clint L.; Wolf, Matthew J.; Periasamy, Ammasi; Steinberg, Gregory R.; Hardie, D. Grahame; Yan, Zhen

Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1 醛缩酶是低和高葡萄糖的传感器，与AMPK和mTORC1连接

CELL RESEARCH

IF25.9

2020-12-21

OAAI

Li, Mengqi; Zhang, Chen-Song; Feng, Jin-Wei; Wei, Xiaoyan; Zhang, Cixiong; Xie, Changchuan; Wu, Yaying; Hawley, Simon A.; Atrih, Abdelmadjid; Lamont, Douglas J.; Wang, Zhichao; Piao, Hai-Long; Hardie, D. Grahame; Lin, Sheng-Cai

AMPK as a direct sensor of long-chain fatty acyl-CoA esters

NATURE METABOLISM

IF20.8

2020-07-27

PREAI

Hardie, D. Grahame

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner

FASEB JOURNAL

IF4.2

2020-03-22

115

OAAI

Seabright, Alex P.; Fine, Nicholas H. F.; Barlow, Jonathan P.; Lord, Samuel O.; Musa, Ibrahim; Gray, Alexander; Bryant, Jack A.; Banzhaf, Manuel; Lavery, Gareth G.; Hardie, D. Grahame; Hodson, David J.; Philp, Andrew; Lai, Yu-Chiang

研究方向