R.K. Cheng - Publications, H-index & Citations

R.K. Cheng

university zurich hospital

45H指数

197论文数

7.5K被引数

收录论文 33

发表时间

An integrated experimental and computational pipeline for crystallographic fragment screening of membrane protein in the lipid cubic phase 膜蛋白在脂质立方相中的晶体学片段筛选集成实验与计算流程

Communications Chemistry

IF6.2

2026-05-13

OAAI

Chia-Ying Huang; Robert Cheng; Alexander Metz; Denis Bucher; Fabio Andres; Arianna Bacchin; Hannah Glover; Christoph P. Sager; Meitian Wang; Michel O. Steinmetz; Michael Hennig; May Sharpe

Structural Mechanism of an Efficacy Photoswitch Targeting the β2-adrenergic Receptor 靶向β2-肾上腺素受体的效应光开关的结构机制

Angewandte Chemie International Edition

IF16.9

2026-03-18

OAAI

Robin Stipp; Quentin Bertrand; Matilde Trabuco; Anna Duran-Corbera; Maria Tindara Ignazzitto; Hannah Glover; Fabienne Stierli; Juanlo Catena; Melissa Carrillo; Sina Hartmann; Hans-Peter Seidel; Matthias Mulder; Thomas Mason; Yasushi Kondo; Maximillian Wranik; Martin Appleby; Christoph Sager; Raymond Sierra; Gregory Gate; Pamela Schleissner; Xinxin Cheng; Tobias Weinert; Robert Cheng; Sandra Mous; John H. Beale; Michal Kepa; Amadeu Llebaria; Michael Hennig; Xavier Rovira; Joerg Standfuss

A novel GPR68 (OGR1) negative allosteric modulator shows efficacy in the Dextran Sulphate Sodium (DSS)-induced mouse model of Ulcerative Colitis and modulates the immunosuppressive phenotype of human colorectal fibroblasts 一种新型GPR68（OGR1）负向别构调节剂在葡聚糖硫酸钠（DSS）诱导的溃疡性结肠炎小鼠模型中显示出疗效，并调节人结直肠成纤维细胞的免疫抑制表型

Journal of Crohns & Colitis

IF8.7

2026-01-01

PREAI

Bingham, M.; Cheng, R.; Sager, C. P.; Remen, L.; March, H. N.; Gallagher, L.; Seuwen, K.; Hennig, M.; Doris, N. R. C.

Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand 代谢性谷氨酸受体5跨膜结构域的apo状态结构，采用光开关配体获得

Protein Science

IF5.2

2025-06-16

OAAI

Yasushi Kondo; Caitlin Hatton; Robert Cheng; Matilde Trabuco; Hannah Glover; Quentin Bertrand; Fabienne Stierli; Hans-Peter Seidel; Thomas Mason

Kinetic Basis for the Design of Azobenzene-Based Photoswitchable A2a Adenosine Receptor Ligands

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-11-13

PREAI

Sassmannshausen, Torben; Glover, Hannah; Trabuco, Matilde; Neidhart, Werner; Cheng, Robert; Hennig, Michael; Slavov, Chavdar; Standfuss, Joerg; Wachtveitl, Josef

Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-08-22

PREAI

Skudlarek, Jason W.; Cooke, Andrew J.; Mitchell, Helen J.; Babaoglu, Kerim; Shaw, Anthony W.; Tong, Ling; Nomland, Ashley B.; Labroli, Marc; Sha, Deyou; Mulhearn, James J.; Wu, Chengwei; Li, Sarah W.; Beshore, Douglas C.; Hughes, Jonathan M. E.; Jouffroy, Matthieu; Wang, Hao; Balibar, Carl J.; Painter, Ronald E.; Shen, Pamela; Lange, Henry S.; Ishchenko, Andrii; Chen, Yun-Ting; Klein, Daniel J.; Tracy, Rodger W.; Miller, Randy R.; Cabalu, Tamara D.; Wu, Zhe; Leithead, Andrew; Scapin, Giovanna; Hruza, Alan W.; Dzhekieva, Liudmila; Bukhtiyarova, Marina; Homsher, Michelle F.; Xu, Min; Bahnck-Teets, Carolyn; McKenney, David; Buevich, Alexei V.; Liu, Jian; Zhang, Li-Kang; Meng, Tao; Kelly, Terri; Dinunzio, Edward; Soisson, Stephen; Cheng, Robert K. Y.; Hennig, Michael; Raheem, Izzat; Walker, Scott S.

Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction

COMMUNICATIONS CHEMISTRY

IF6.2

2023-06-01

OAAI

Claff, Tobias; Schlegel, Jonathan G.; Voss, Jan H.; Vaassen, Victoria J.; Weisse, Renato H.; Cheng, Robert K. Y.; Markovic-Mueller, Sandra; Bucher, Denis; Straeter, Norbert; Mueller, Christa E.

Investigating the role of non-canonical NF-kappaB signaling in tumor cells and macrophages in ovarian cancer

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Wilson, Andrew J.; Parker, Dominique; Cheng, Robert; Giorgio, Todd; Crispens, Marta; Yull, Fiona

Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators

PNAS NEXUS

IF3.8

2022-06-16

OAAI

Botte, Mathieu; Huber, Sophie; Bucher, Denis; Klint, Julie K.; Rodriguez, David; Tagmose, Lena; Chami, Mohamed; Cheng, Robert; Hennig, Michael; Rahman, Wassim Abdul

Acoustic levitation and rotation of thin films and their application for room temperature protein crystallography (vol 12, 5349, 2022)

SCIENTIFIC REPORTS

IF3.9

2022-04-25

OAAI

Kepa, Michal. W.; Tomizaki, Takashi; Sato, Yohei; Ozerov, Dmitry; Sekiguchi, Hiroshi; Yasuda, Nobuhiro; Aoyama, Koki; Skopintsev, Petr; Standfuss, Jorg; Cheng, Robert; Hennig, Michael; Tsujino, Soichiro

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation

NATURE COMMUNICATIONS

IF15.7

2022-04-05

OAAI

Botte, Mathieu; Ni, Dongchun; Schenck, Stephan; Zimmermann, Iwan; Chami, Mohamed; Bocquet, Nicolas; Egloff, Pascal; Bucher, Denis; Trabuco, Matilde; Cheng, Robert K. Y.; Brunner, Janine D.; Seeger, Markus A.; Stahlberg, Henning; Hennig, Michael

Acoustic levitation and rotation of thin films and their application for room temperature protein crystallography

SCIENTIFIC REPORTS

IF3.9

2022-03-30

OAAI

Kepa, Michal W.; Tomizaki, Takashi; Sato, Yohei; Ozerov, Dmitry; Sekiguchi, Hiroshi; Yasuda, Nobuhiro; Aoyama, Koki; Skopintsev, Petr; Standfuss, Jorg; Cheng, Robert; Hennig, Michael; Tsujino, Soichiro

Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A2A Receptor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-03-25

OAAI

Amelia, Tasia; van Veldhoven, Jacobus P. D.; Falsini, Matteo; Liu, Rongfang; Heitman, Laura H.; van Westen, Gerard J. P.; Segala, Elena; Verdon, Gregory; Cheng, Robert K. Y.; Cooke, Robert M.; van der Es, Daan; IJzerman, Adriaan P.

In situ crystallography as an emerging method for structure solution of membrane proteins: the case of CCR2A

FEBS JOURNAL

IF4.2

2019-11-06

OAAI

Cheng, Robert; Huang, Chia-Ying; Hennig, Michael; Nar, Herbert; Schnapp, Gisela

Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals 迈向高通量GPCR晶体学: 在腺苷A2A受体晶体的中观浸泡中

SCIENTIFIC REPORTS

IF3.9

2018-01-08

OAAI

Rucktooa, Prakash; Cheng, Robert K. Y.; Segala, Elena; Geng, Tian; Errey, James C.; Brown, Giles A.; Cooke, Robert M.; Marshall, Fiona H.; Dore, Andrew S.

X-ray free electron laser: opportunities for drug discovery

STRUCTURE-BASED DRUG DESIGN: INSIGHTS FROM ACADEMIA AND INDUSTRY

IF0

2017-11-08

PREAI

Cheng, Robert K. Y.; Abela, Rafael; Hennig, Michael

Transient and limit cycle combustion dynamics analysis of turbulent premixed swirling flames 湍流预混旋流火焰的瞬态和极限环燃烧动力学分析

JOURNAL OF FLUID MECHANICS

IF3.9

2017-10-05

PREAI

Palies, Paul; Ilak, Milos; Cheng, Robert

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

NATURE COMMUNICATIONS

IF15.7

2017-09-14

209

OAAI

Weinert, Tobias; Olieric, Natacha; Cheng, Robert; Bruenle, Steffen; James, Daniel; Ozerov, Dmitry; Gashi, Dardan; Vera, Laura; Marsh, May; Jaeger, Kathrin; Dworkowski, Florian; Panepucci, Ezequiel; Basu, Shibom; Skopintsev, Petr; Dore, Andrew S.; Geng, Tian; Cooke, Robert M.; Liang, Mengning; Prota, Andrea E.; Panneels, Valerie; Nogly, Przemyslaw; Ermler, Ulrich; Schertler, Gebhard; Hennig, Michael; Steinmetz, Michel O.; Wang, Meitian; Standfuss, Jorg

Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-07-01

155

OAAI

Segala, Elena; Guo, Dong; Cheng, Robert K. Y.; Bortolato, Andrea; Deflorian, Francesca; Dore, Andrew S.; Errey, James C.; Heitman, Laura H.; IJzerman, Adriaan P.; Marshall, Fiona H.; Cooke, Robert M.

Topology and burning rates of turbulent, lean, H2/air flames

COMBUSTION AND FLAME

IF6.2

2015-12-01

OAAI

Amato, Alberto; Day, Marcus; Cheng, Robert K.; Bell, John; Dasgupta, Debolina; Lieuwen, Tim

研究方向