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M

Michel O. Steinmetz

Paul Scherrer Institut
H指数:82
被引数:2.2万

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Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling

紫杉烷诱导微管晶格构象变化激活GEF-H1依赖的RhoA信号通路

Nature Cell Biology
IF19.1
2026-09-240
OAAI
Joyce C. M. Meiring; Varsha Mahapatra; Ruijie Liu; Molly S. C. Gravett; Daan Morren; Harriet A. J. Saunders; Sung Ryul Choi; Andressa Pelster José; Adela Karhanova; Ioanna Metallidou; Alex Moore; Marèl F. M. Spoelstra; Ilya S. Grigoriev; Matteo Giono; Saishree S. Iyer; Samantha J. Stehbens; J. Fernando Díaz; Zdenek Lansky; Kelly E. Stecker; Michel O. Steinmetz; Stuart C. Howes; Lukas C. Kapitein; Anna Akhmanova
Structural basis of microtubule-mediated signal transduction

微管介导的信号转导的结构基础

Cell
IF42.5
2025-12-080
OAAI
Sung Ryul Choi; Thorsten B. Blum; Matteo Giono; Bibhas Roy; Ioannis Vakonakis; Dominic Schmid; Nicole Oelgarth; Apisha Ranganathan; Alvar D. Gossert; G.V. Shivashankar; Alfred Zippelius; Michel O. Steinmetz
Asymmetric Total Synthesis of (−)-Glycybridin B, a Pharmacophore Screened Candidate for Tubulin Binding

(−)-Glycybridin B的不对称全合成，一种用于微管结合的药效基筛选候选物

Chemistry – A European Journal
IF0
2025-08-060
OAAI
Dr. Alice Maiocchi; Dr. Maxim Shevelev; Dr. Zlata Boiarska; Dr. Juan Estévez-Gallego; Dr. Francesca Bonato; Dr. Paolo Orlando; Alessandra Chinosi; Emanuele Marcone; Dr. Andrea Citarella; Dr. Dragos Horvath; Prof. Dr. Michel O. Steinmetz; Dr. Andrea E. Prota; Dr. Alexandre Varnek; Dr. Valerio Fasano; Prof. Dr. Daniele Passarella
Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends

中心粒帽蛋白CP110和CPAP调控微管正极的缓慢延长

JOURNAL OF CELL BIOLOGY
IF6.4
2025-01-230
OA
Iyer, Saishree S.; Chen, Fangrui; Ogunmolu, Funso E.; Moradi, Shoeib; Volkov, Vladimir A.; van Grinsven, Emma J.; van Hoorn, Chris; Wu, Jingchao; Andrea, Nemo; Hua, Shasha; Jiang, Kai; Vakonakis, Ioannis; Potocnjak, Mia; Herzog, Franz; Gigant, Benoit; Gudimchuk, Nikita; Stecker, Kelly E.; Dogterom, Marileen; Steinmetz, Michel O.; Akhmanova, Anna
Modular synthesis of functional libraries by accelerated SuFEx click chemistry
CHEMICAL SCIENCE
IF7.4
2024-01-013
OAAI
Homer, Joshua A.; Koelln, Rebecca A.; Barrow, Andrew S.; Gialelis, Timothy L.; Boiarska, Zlata; Steinohrt, Nikita S.; Lee, Erinna F.; Yang, Wen-Hsuan; Johnson, Robert M.; Chung, Taemoon; Habowski, Amber N.; Vishwakarma, Dharmendra S.; Bhunia, Debmalya; Avanzi, Charlotte; Moorhouse, Adam D.; Jackson, Mary; Tuveson, David A.; Lyons, Scott K.; Lukey, Michael J.; Fairlie, W. Douglas; Haider, Shozeb M.; Steinmetz, Michel O.; Prota, Andrea E.; Moses, John E.
A photo-SAR study of photoswitchable azobenzene tubulin-inhibiting antimitotics identifying a general method for near-quantitative photocontrol
CHEMICAL SCIENCE
IF7.4
2024-01-010
OAAI
Reynders, Martin; Garscia, Malgorzata; Mueller-Deku, Adrian; Wranik, Maximilian; Krauskopf, Kristina; de la Rosa, Luis de la Osa; Schaffer, Konstantin; Joetten, Anna; Rode, Alexander; Stierle, Valentin; Kraus, Yvonne; Baumgartner, Benedikt; Ali, Ahmed; Bubeneck, Andrei; Seal, Trina; Steinmetz, Michel O.; Paulitschke, Philipp; Thorn-Seshold, Oliver
A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers

用于x射线自由电子激光器的时间分辨系列蛋白质晶体学和化合物筛选的多储层挤出机

NATURE COMMUNICATIONS
IF15.7
2023-12-022
OAAI
Wranik, Maximilian; Kepa, Michal W.; Beale, Emma V.; James, Daniel; Bertrand, Quentin; Weinert, Tobias; Furrer, Antonia; Glover, Hannah; Gashi, Dardan; Carrillo, Melissa; Kondo, Yasushi; Stipp, Robin T.; Khusainov, Georgii; Nass, Karol; Ozerov, Dmitry; Cirelli, Claudio; Johnson, Philip J. M.; Dworkowski, Florian; Beale, John H.; Stubbs, Scott; Zamofing, Thierry; Schneider, Marco; Krauskopf, Kristina; Gao, Li; Thorn-Seshold, Oliver; Bostedt, Christoph; Bacellar, Camila; Steinmetz, Michel O.; Milne, Christopher; Standfuss, Jorg
Structural insight into the stabilization of microtubules by taxanes

紫杉烷类化合物对微管稳定的结构见解

ELIFE
IF0
2023-03-0623
OA
Prota, Andrea E.; Lucena-Agell, Daniel; Ma, Yuntao; Estevez-Gallego, Juan; Li, Shuo; Bargsten, Katja; Josa-Prado, Fernando; Altmann, Karl-Heinz; Gaillard, Natacha; Kamimura, Shinji; Muhlethaler, Tobias; Gago, Federico; Oliva, Maria A.; Steinmetz, Michel O.; Fang, Wei-Shuo; Diaz, J. Fernando
Watching the release of a photopharmacological drug from tubulin using time-resolved serial crystallography
NATURE COMMUNICATIONS
IF15.7
2023-02-1716
OAAI
Wranik, Maximilian; Weinert, Tobias; Slavov, Chavdar; Masini, Tiziana; Furrer, Antonia; Gaillard, Natacha; Gioia, Dario; Ferrarotti, Marco; James, Daniel; Glover, Hannah; Carrillo, Melissa; Kekilli, Demet; Stipp, Robin; Skopintsev, Petr; Brunle, Steffen; Muhlethaler, Tobias; Beale, John; Gashi, Dardan; Nass, Karol; Ozerov, Dmitry; Johnson, Philip J. M.; Cirelli, Claudio; Bacellar, Camila; Braun, Markus; Wang, Meitian; Dworkowski, Florian; Milne, Chris; Cavalli, Andrea; Wachtveitl, Josef; Steinmetz, Michel O. O.; Standfuss, Jorg
Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2022-12-0133
PRE
Barreca, Marilia; Span, Virginia; Rocca, Roberta; Bivacqua, Roberta; Abel, Anne -Catherine; Maruca, Annalisa; Montalbano, Alessandra; Raimondi, Maria Valeria; Tarantelli, Chiara; Gaudio, Eugenio; Cascione, Luciano; Rinaldi, Andrea; Bai, Ruoli; Steinmetz, Michel O.; Prota, Andrea E.; Alcaro, Stefano; Hamel, Ernest; Bertoni, Francesco; Barraja, Paola

研究方向

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A
Anna Akhmanova
H 指数:90论文数:534被引数:2.6万
A
A.E. Prota
H 指数:40论文数:209被引数:5,979
R
Richard A. Kammerer
H 指数:49论文数:145被引数:6,676
N
Natacha Olieric
H 指数:26论文数:67被引数:2,429
J
J. Fernando Dı́az
H 指数:52论文数:233被引数:9,070
K
Katja Bargsten
H 指数:23论文数:78被引数:3,456
H
Honnappa Srinivas
H 指数:22论文数:62被引数:3,622
I
Ilya Grigoriev
H 指数:42论文数:87被引数:7,983
K
Kai Jiang
H 指数:36论文数:145被引数:4,776
U
Ueli Aebi
H 指数:106论文数:503被引数:3.3万