Ming‐Der Perng - Publications, H-index & Citations

Ming‐Der Perng

national tsing hua university

14H指数

29论文数

616被引数

收录论文 14

发表时间

Synergistic Effects of Glial Fibrillary Acidic Protein Mutation and Overexpression in the Pathogenesis of Alexander Disease 星形胶质细胞纤维酸性蛋白突变和过表达在亚历山大病发病机制中的协同效应

International Journal of Molecular Sciences

IF4.9

2026-05-15

OAAI

Ni-Hsuan Lin; Ming-Der Perng

Phenotypic and molecular characterization of a recurrent SPTAN1 mutation causing SPG91 SPG91致病性复发SPTAN1突变的表型与分子特征分析

MOLECULAR BIOLOGY REPORTS

IF2.8

2025-05-21

PREAI

Lan, Shih-Chun; Perng, Ming-Der; Chang, Yung-Yee; Chen, Ying-Fa

Deletions in Glial Fibrillary Acidic Protein Leading to Alterations in Intermediate Filament Assembly and Network Formation 胶质纤维酸性蛋白中的缺失导致中间丝组装和网络形成的改变

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IF4.9

2025-02-23

OAAI

Lin, Ni-Hsuan; Jian, Wan-Syuan; Perng, Ming-Der

Effects of Alexander disease-associated mutations on the assembly and organization of GFAP intermediate filaments

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2022-07-01

OAAI

Yang, Ai-Wen; Lin, Ni-Hsuan; Yeh, Ting-Hung; Snider, Natasha; Perng, Ming-Der

A novel in-frame GFAP p.E138_L148del mutation in Type II Alexander disease with atypical phenotypes

EUROPEAN JOURNAL OF HUMAN GENETICS

IF4.6

2022-03-04

OAAI

Kang, You-Ri; Lee, So-Hyun; Lin, Ni-Hsuan; Lee, Seung-Jin; Yang, Ai-Wen; Chandrasekaran, Gopalakrishnan; Kang, Kyung Wook; Jin, Mi Sun; Kim, Myeong-Kyu; Perng, Ming-Der; Choi, Seok-Yong; Nam, Tai-Seung

Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2021-11-17

OAAI

Hagemann, Tracy L.; Powers, Berit; Lin, Ni-Hsuan; Mohamed, Ahmed F.; Dague, Katerina L.; Hannah, Seth C.; Bachmann, Gemma; Mazur, Curt; Rigo, Frank; Olsen, Abby L.; Feany, Mel B.; Perng, Ming-Der; Berman, Robert F.; Messing, Albee

Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function GFAP亚型表达升高促进蛋白质聚集并损害星形胶质细胞功能

FASEB JOURNAL

IF4.2

2021-04-28

PREAI

Lin, Ni-Hsuan; Yang, Ai-Wen; Chang, Chih-Hsuan; Perng, Ming-Der

Recessively-Inherited Adult-Onset Alexander Disease Caused by a Homozygous Mutation in the GFAP Gene

MOVEMENT DISORDERS

IF7.6

2020-05-06

OAAI

Fu, Mu-Hui; Chang, Yung-Yee; Lin, Ni-Hsuan; Yang, Ai-Wen; Chang, Chiung-Chih; Liu, Jia-Shou; Peng, Cheng-Huei; Wu, Kay L. H.; Perng, Ming-Der; Lan, Min-Yu

Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity

ELIFE

IF0

2019-11-04

OAAI

Battaglia, Rachel A.; Beltran, Adriana S.; Delic, Samed; Dumitru, Raluca; Robinson, Jasmine A.; Kabiraj, Parijat; Herring, Laura E.; Madden, Victoria J.; Ravinder, Namritha; Willems, Erik; Newman, Rhonda A.; Quinlan, Roy A.; Goldman, James E.; Perng, Ming-Der; Inagaki, Masaki; Snider, Natasha T.

Identification of a novel nonsense mutation in the rod domain of GFAP that is associated with Alexander disease

EUROPEAN JOURNAL OF HUMAN GENETICS

IF4.6

2014-04-23

OAAI

Nam, Tai-Seung; Kim, Jin Hee; Chang, Chi-Hsuan; Yoon, Woong; Jung, Yoon Seok; Kang, Sa-Yoon; Shin, Boo Ahn; Perng, Ming-Der; Choi, Seok-Yong; Kim, Myeong-Kyu

Caspase cleavage of GFAP produces an assembly-compromised proteolytic fragment that promotes filament aggregation

ASN NEURO

IF3.7

2013-11-19

OAAI

Chen, Mei-Hsuan; Hagemann, Tracy L.; Quinlan, Roy A.; Messing, Albee; Perng, Ming-Der

Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability

EXPERIMENTAL CELL RESEARCH

IF3.5

2011-10-01

OAAI

Chen, Yi-Song; Lim, Suh-Ciuan; Chen, Mei-Hsuan; Quinlan, Roy A.; Perng, Ming-Der