Zhiguo Chen

University of Virginia

H指数:22

被引数:2,201

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Disruption of Krox20-Notch1 signaling blocks meibomian gland development and homeostasis leading to dry eye disease

Krox20-Notch1信号通路的破坏会阻断睑板腺的发育和稳态，从而导致干眼病。

Nature Communications

IF15.7

2025-11-230

OAAI

Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins (vol 135, e199700, 2025)

人源化神经纤维瘤模型源自诱导多能干细胞，阐述了肿瘤的发病机制和发育起源（卷135，e199700，2025）

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2025-10-150

PRE

Corrigendum to “Immune-related biomarkers in the neuromyelitis optica spectrum disorder; pathogenesis and therapeutic approaches” [Experim. Eye Res. 256 110395]

勘误：“Immune-related biomarkers in the neuromyelitis optica spectrum disorder; pathogenesis and therapeutic approaches” [Experim. Eye Res. 256 110395]

Experimental Eye Research

IF2.7

2025-09-230

PRE

视神经脊髓炎谱系障碍中的免疫相关生物标志物；发病机制和治疗策略

EXPERIMENTAL EYE RESEARCH

IF2.7

2025-07-010

PRE

Dexrazoxane inhibits the growth of esophageal squamous cell carcinoma by attenuating SDCBP/MDA-9/syntenin-mediated EGFR-PI3K-Akt pathway activation

SCIENTIFIC REPORTS

IF3.9

2024-04-222

OAAI

STING activation reprograms the microenvironment to sensitize NF1-related malignant peripheral nerve sheath tumors for immunotherapy

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2024-03-191

OAAI

DNA four-way junction-driven dual-rolling circle amplification sandwich-type aptasensor for ultra-sensitive and specific detection of tumor-derived exosomes

BIOSENSORS & BIOELECTRONICS

IF10.5

2024-02-0110

PRE

Two decades of a protooncogene TBL1XR1: from a transcription modulator to cancer therapeutic target

FRONTIERS IN ONCOLOGY

IF3.3

2024-01-293

OAAI

Machine learning-identified stemness features and constructed stemness-related subtype with prognosis, chemotherapy, and immunotherapy responses for non-small cell lung cancer patients

STEM CELL RESEARCH & THERAPY

IF7.3

2023-09-072

OAAI

Bioinformatics and experimental validation of an AURKA/TPX2 axis as a potential target in esophageal squamous cell carcinoma

ONCOLOGY REPORTS

IF3.9

2023-04-206

OAAI

Comprehensive Analysis Reveals USP45 as a Novel Putative Oncogene in Pan-Cancer

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2022-06-289

OAAI

CircTP53 promotes colorectal cancer by acting as a miR-876-3p sponge to increase cyclin-dependent kinase-like 3 expression

CELLULAR SIGNALLING

IF3.7

2021-02-0114

PREAI

Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2021-01-0457

Schwannoma development is mediated by Hippo pathway dysregulation and modified b RAS/MAPK signaling

JCI INSIGHT

IF6.1

2020-10-1522

OAAI

New insights into the neurofibroma tumor cells of origin

NEURO-ONCOLOGY ADVANCES

IF4.1

2019-11-1017

OAAI

Overcoming BET Inhibitor Resistance in Malignant Peripheral Nerve Sheath Tumors

CLINICAL CANCER RESEARCH

IF10.2

2019-06-0317

OAAI

Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway

CANCER DISCOVERY

IF33.3

2019-01-0975

OAAI

MiR-532-5p suppresses renal cancer cell proliferation by disrupting the ETS1-mediated positive feedback loop with the KRAS-NAP1L1/P-ERK axis

BRITISH JOURNAL OF CANCER

IF6.8

2018-08-0768

OAAI

BET inhibitor synthetic lethality in malignant peripheral nerve sheath tumors

CANCER RESEARCH

IF16.6

2018-07-010

PRE

Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2018-05-21123

Zhiguo Chen

个人简介

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