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R

Reza Kiarash

University of Toronto
H指数:15
被引数:1,756

个人简介

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工作经历

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荣誉奖项

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The spindle assembly checkpoint is a therapeutic vulnerability of CDK4/6 inhibitor-resistant ER+ breast cancer with mitotic aberrations

纺锤体组装检查点是具有有丝分裂畸变的CDK4/6抑制剂抗性ER乳腺癌的治疗脆弱性

SCIENCE ADVANCES
IF12.5
2022-09-0921
OAAI
Soria-Bretones, Isabel; Thu, Kelsie L.; Silvester, Jennifer; Cruickshank, Jennifer; El Ghamrasni, Samah; Ba-alawi, Wail; Fletcher, Graham C.; Kiarash, Reza; Elliott, Mitchell J.; Chalmers, Jordan J.; Elia, Andrea C.; Cheng, Albert; Rose, April A. N.; Bray, Mark R.; Haibe-Kains, Benjamin; Mak, Tak W.; Cescon, David W.
Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2016-05-0672
OAAI
Liu, Yong; Laufer, Radoslaw; Patel, Narendra Kumar; Ng, Grace; Sampson, Peter B.; Li, Sze-Wan; Lang, Yunhui; Feher, Miklos; Brokx, Richard; Beletskaya, Irina; Hodgson, Richard; Plotnikova, Olga; Awrey, Donald E.; Qiu, Wei; Chirgadze, Nickolay Y.; Mason, Jacqueline M.; Wei, Xin; Lin, Dan Chi-Chia; Che, Yi; Kiarash, Reza; Fletcher, Graham C.; Mak, Tak W.; Bray, Mark R.; Pauls, Henry W.
The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-04-0357
PREAI
Liu, Yong; Lang, Yunhui; Patel, Narendra Kumar; Ng, Grace; Laufer, Radoslaw; Li, Sze-Wan; Edwards, Louise; Forrest, Bryan; Sampson, Peter B.; Feher, Miklos; Ban, Fuqiang; Awrey, Donald E.; Beletskaya, Irina; Mao, Guodong; Hodgson, Richard; Plotnikova, Olga; Qiu, Wei; Chirgadze, Nickolay Y.; Mason, Jacqueline M.; Wei, Xin; Lin, Dan Chi-Chia; Che, Yi; Kiarash, Reza; Madeira, Brian; Fletcher, Graham C.; Mak, Tak W.; Bray, Mark R.; Pauls, Henry W.
Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides
BIOORGANIC & MEDICINAL CHEMISTRY
IF3
2014-09-0140
PREAI
Laufer, Radoslaw; Ng, Grace; Liu, Yong; Patel, Narendra Kumar B.; Edwards, Louise G.; Lang, Yunhui; Li, Sze-Wan; Feher, Miklos; Awrey, Don E.; Leung, Genie; Beletskaya, Irina; Plotnikova, Olga; Mason, Jacqueline M.; Hodgson, Richard; Wei, Xin; Mao, Guodong; Luo, Xunyi; Huang, Ping; Green, Erin; Kiarash, Reza; Lin, Dan Chi-Chia; Harris-Brandts, Marees; Ban, Fuqiang; Nadeem, Vincent; Mak, Tak W.; Pan, Guohua J.; Qiu, Wei; Chirgadze, Nickolay Y.; Pauls, Henry W.
The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-06-2436
PREAI
Sampson, Peter B.; Liu, Yong; Patel, Narendra Kumar; Feher, Miklos; Forrest, Bryan; Li, Sze-Wan; Edwards, Louise; Laufer, Radoslaw; Lang, Yunhui; Ban, Fuqiang; Awrey, Donald E.; Mao, Guodong; Plotnikova, Olga; Leung, Genie; Hodgson, Richard; Mason, Jacqueline; Wei, Xin; Kiarash, Reza; Green, Erin; Qiu, Wei; Chirgadze, Nickolay Y.; Mak, Tak W.; Pan, Guohua; Pauls, Henry W.
The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-06-24178
PREAI
Sampson, Peter B.; Liu, Yong; Forrest, Bryan; Cumming, Graham; Li, Sze-Wan; Patel, Narendra Kumar; Edwards, Louise; Laufer, Radoslaw; Feher, Miklos; Ban, Fuqiang; Awrey, Donald E.; Mao, Guodong; Plotnikova, Olga; Hodgson, Richard; Beletskaya, Irina; Mason, Jacqueline M.; Luo, Xunyi; Nadeem, Vincent; Wei, Xin; Kiarash, Reza; Madeira, Brian; Huang, Ping; Mak, Tak W.; Pan, Guohua; Pauls, Henry W.
The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2013-07-2670
PREAI
Laufer, Radoslaw; Forrest, Bryan; Li, Sze-Wan; Liu, Yong; Sampson, Peter; Edwards, Louise; Lang, Yunhui; Awrey, Donald E.; Mao, Guodong; Plotnikova, Olga; Leung, Genie; Hodgson, Richard; Beletskaya, Irina; Mason, Jacqueline M.; Luo, Xunyi; Wei, Xin; Yao, Yi; Feher, Miklos; Ban, Fuqiang; Kiarash, Reza; Green, Erin; Mak, Tak W.; Pan, Guohua; Pauls, Henry W.
Inhibition of Polo-like kinase 4 as an anti-cancer strategy
CANCER RESEARCH
IF16.6
2011-04-013
PRE
Mason, Jacqueline; Wei, Sam; Luo, Xunyi; Nadeem, Vincent; Kiarash, Reza; Huang, Ping; Awrey, Don; Leung, Genie; Beletskaya, Irina; Feher, Miklos; Forrest, Bryan; Laufer, Radek; Sampson, Peter; Li, Sze-Wan; Liu, Yong; Lang, Yunhui; Pauls, Henry; Mak, Tak; Pan, James Guohua

研究方向

暂未获取到该数据
T
Tak W. Mak
H 指数:181论文数:1,561被引数:12.9万
J
Jacqueline M. Mason
H 指数:27论文数:42被引数:4,316
R
Richard Hodgson
H 指数:42论文数:201被引数:5,042
M
Mark R. Bray
H 指数:30论文数:137被引数:4,183
I
I. P. Beletskaya
H 指数:71论文数:1,925被引数:3.3万
S
Sze-Wan Li
H 指数:9论文数:10被引数:641
G
Graham C. Fletcher
H 指数:20论文数:40被引数:2,872
M
Miklós Fehér
H 指数:31论文数:178被引数:3,985
H
Henry W. Pauls
H 指数:25论文数:88被引数:1,951
O
Olga Plotnikova
H 指数:22论文数:34被引数:2,381