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PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice Yang, Tao; Huhe, Hasi; Williams, Sean-paul; Kaur, Sukhneet; Ay, Yeonglong Albert; Davis-gilbert, Zachary W.; Cary, Gregory A.; Paisie, Carolyn; Butler, Robert R.; Wiley, Jesse; Betarbet, Ranjita; Fu, Haian; Duong, Duc; Seyfried, Nicholas T.; Leal, Karina; Carter, Gregory W.; Edwards, Aled; Levey, Allan I.; Capener, Jacob L.; Drewry, David H.; Hossain, Mohammad A.; Oh, Hans J.; Axtman, Alison D.; Sukoff Rizzo, Stacey J.; Longo, Frank M. 分享 收藏
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p75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia p75NTR调控可防止围产期缺氧引起的细胞、皮层活动及认知功能障碍。Brain. 148, 2965–2980 Chattopadhyaya, Bidisha; Lee, Karen K. Y.; Carreno-Munoz, Maria Isabel; Paris-Rubianes, Andrea; Lavertu-Jolin, Marisol; Berryer, Martin H.; Longo, Frank M.; Di Cristo, Graziella 分享 收藏
Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction 帕金森病的特点是维生素B6依赖性的炎症犬尿氨酸通路功能障碍。 Wilson, Edward N.; Umans, Jacob; Swarovski, Michelle S.; Minhas, Paras S.; Mendiola, Justin H.; Midttun, Oivind; Ulvik, Arve; Shahid-Besanti, Marian; Linortner, Patricia; Mhatre, Siddhita D.; Wang, Qian; Channappa, Divya; Corso, Nicole K.; Tian, Lu; Fredericks, Carolyn A.; Kerchner, Geoffrey A.; Plowey, Edward D.; Cholerton, Brenna; Ueland, Per M.; Zabetian, Cyrus P.; Gray, Nora E.; Quinn, Joseph F.; Montine, Thomas J.; Sha, Sharon J.; Longo, Frank M.; Wolk, David A.; Chen-Plotkin, Alice; Henderson, Victor W.; Wyss-Coray, Tony; Wagner, Anthony D.; Mormino, Elizabeth C.; Aghaeepour, Nima; Poston, Kathleen L.; Andreasson, Katrin I. 分享 收藏
Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington's disease phenotypes 人纹状体祖细胞含有可诱导的安全措施并过表达BDNF，可拯救亨廷顿病表型。 Simmons, Danielle A.; Selvaraj, Sridhar; Chen, Tingshuo; Cao, Gloria; Camelo, Talita Souto; Mchugh, Tyne L. M.; Gonzalez, Selena; Martin, Renata M.; Simanauskaite, Juste; Uchida, Nobuko; Porteus, Matthew H.; Longo, Frank M. 分享 收藏
Plasma Aβ42/Aβ40 is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum Trelle, Alexandra N.; Young, Christina B.; Vossler, Hillary; Benitez, Javier Ramos; Cody, Karly A.; Mendiola, Justin H.; Swarovski, Michelle S.; Guen, Yann Le; Feinstein, Igor; Butler III, Robert R.; Channappa, Divya; Romero, America; Park, Jennifer; Shahid-Besanti, Marian; Corso, Nicole K.; Chau, Kelly; Smith, Amanda N.; Skylar-Scott, Irina; Yutsis, Maya V.; Fredericks, Carolyn A.; Tian, Lu; Younes, Kyan; Kerchner, Geoffrey A.; Deutsch, Gayle K.; Davidzon, Guido A.; Sha, Sharon J.; Henderson, Victor W.; Longo, Frank M.; Greicius, Michael D.; Wyss-Coray, Tony; Andreasson, Katrin I.; Poston, Kathleen L.; Wagner, Anthony D.; Mormino, Elizabeth C.; Wilson, Edward N. 分享 收藏
A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice Medeiros, Destynie; Ayala-Baylon, Karen; Egido-Betancourt, Hailey; Miller, Eric; Chapleau, Christopher; Robinson, Holly; Phillips, Mary L.; Yang, Tao; Longo, Frank M.; Li, Wei; Pozzo-Miller, Lucas 分享 收藏
A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model Latif-Hernandez, Amira; Yang, Tao; Raymond-Butler III, Robert; Losada, Patricia Moran; Minhas, Paras S.; White, Halle; Tran, Kevin C.; Liu, Harry; Simmons, Danielle A.; Langness, Vanessa; Andreasson, Katrin I.; Wyss-Coray, Tony; Longo, Frank M. 分享 收藏
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial Shanks, Hayley R. C.; Chen, Kewei; Reiman, Eric M.; Blennow, Kaj; Cummings, Jeffrey L.; Massa, Stephen M.; Longo, Frank M.; Borjesson-Hanson, Anne; Windisch, Manfred; Schmitz, Taylor W. 分享 收藏
Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains 阿尔茨海默病的遗传和多组学风险评估涉及核心相关生物学领域 Cary, Gregory A.; Wiley, Jesse C.; Gockley, Jake; Keegan, Stephen; Ganesh, Sai Sruthi Amirtha; Heath, Laura; Butler, Robert R.; Mangravite, Lara M.; Logsdon, Benjamin A.; Longo, Frank M.; Levey, Allan; Greenwood, Anna K.; Carter, Gregory W. 分享 收藏
Modulation of the p75 neurotrophin receptor in the PS19 tauopathy mouse model regulates transcription profiles and inter-cellular communication across multiple populations of non-neuronal cells Butler, Robert R.; Yang, Tao; Han, Crystal; Le Guen, Yann; Tran, Kevin C.; Lallani, Shoeb; Liu, Harry; Leng, Song Albert; Massa, Stephen M.; Longo, Frank M. 分享 收藏
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Open drug discovery in Alzheimer's disease Axtman, Alison. D. E.; Brennan, Paul. E.; Frappier-Brinton, Tristan; Betarbet, Ranjita W.; Carter, Gregory. W.; Fu, Haian; Gileadi, Opher K.; Greenwood, Anna. K.; Leal, Karina M.; Longo, Frank. M. M.; Mangravite, Lara. M. M.; Edwards, Aled. M. I.; Levey, Allan., I 分享 收藏
Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning 内源性时钟蛋白BMAL1的骨髓缺乏通过破坏小胶质细胞突触修剪来加速认知衰老 Iweka, Chinyere Agbaegbu; Seigneur, Erica; Hernandez, Amira Latif; Paredes, Sur Herrera; Cabrera, Mica; Blacher, Eran; Pasternak, Connie Tsai; Longo, Frank M.; de Lecea, Luis; Andreasson, Katrin I. 分享 收藏
Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease Wilson, Edward N.; Young, Christina B.; Benitez, Javier Ramos; Swarovski, Michelle S.; Feinstein, Igor; Vandijck, Manu; Le Guen, Yann; Kasireddy, Nandita M.; Shahid, Marian; Corso, Nicole K.; Wang, Qian; Kennedy, Gabriel; Trelle, Alexandra N.; Lind, Betty; Channappa, Divya; Belnap, Malia; Ramirez, Veronica; Skylar-Scott, Irina; Younes, Kyan; Yutsis, Maya V.; Le Bastard, Nathalie; Quinn, Joseph F.; van Dyck, Christopher H.; Nairn, Angus; Fredericks, Carolyn A.; Tian, Lu; Kerchner, Geoffrey A.; Montine, Thomas J.; Sha, Sharon J.; Davidzon, Guido; Henderson, Victor W.; Longo, Frank M.; Greicius, Michael D.; Wagner, Anthony D.; Wyss-Coray, Tony; Poston, Kathleen L.; Mormino, Elizabeth C.; Andreasson, Katrin I. 分享 收藏
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Post-Stroke Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Attenuates Chronic Changes in Brain Metabolism, Increases Neurotransmitter Levels, and Improves Recovery Nguyen, Thuy-Vi V.; Crumpacker, Rachel H.; Calderon, Kylie E.; Garcia, Frankie G.; Zbesko, Jacob C.; Frye, Jennifer B.; Gonzalez, Selena; Becktel, Danielle A.; Yang, Tao; Tavera-Garcia, Marco A.; Morrison, Helena W.; Schnellmann, Rick G.; Longo, Frank M.; Doyle, Kristian P. 分享 收藏
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Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics He, Zihuai; Guen, Yann Le; Liu, Linxi; Lee, Justin; Ma, Shiyang; Yang, Andrew C.; Liu, Xiaoxia; Rutledge, Jarod; Losada, Patricia Moran; Song, Bowen; Belloy, Michael E.; Butler, Robert R., III; Longo, Frank M.; Tang, Hua; Mormino, Elizabeth C.; Wyss-Coray, Tony; Greicius, Michael D.; Ionita-Laza, Iuliana 分享 收藏
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