Alemayehu A. Gorfe - Publications, H-index & Citations

Alemayehu A. Gorfe

the university of texas health science center

47H指数

171论文数

6.5K被引数

收录论文 87

发表时间

Synthesis and Biochemical Characterization of Investigational Pyrazolopyrimidine-Based Allosteric KRAS Modulators 新型吡唑嘧啶类别构KRAS调节剂的合成与生化表征

ACS Medicinal Chemistry Letters

IF4

2026-05-27

PREAI

Cynthia V. Pagba; Kasuni Dilsha; Rakshya Ojha; Jacob Jakubec; Xiaowen Liang; Abraham C. Sianoya; Paul Mark B. Medina; Scott Gilbertson; Alemayehu A. Gorfe

From disorder comes function: Regulation of small GTPase function by intrinsically disordered lipidated membrane anchor

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2024-08-01

OAAI

Hutchins, Chase M.; Gorfe, Alemayehu A.

Differential Lipid Binding Specificities of RAP1A and RAP1B are Encoded by the Amino Acid Sequence of the Membrane Anchors

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-07-13

OAAI

Araya, Mussie K.; Chen, Wei; Ke, Yuepeng; Zhou, Yubin; Gorfe, Alemayehu A.; Hancock, John F.; Liu, Junchen

A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95

LIFE SCIENCE ALLIANCE

IF2.9

2023-09-04

OAAI

Rehl, Kristen M.; Selvakumar, Jayaraman; Pitsch, Rhonda L.; Hoang, Don; Arumugam, Kuppuswamy; Harshman, Sean W.; Gorfe, Alemayehu A.; Cho, Kwang-Jin

Small-Molecule Inhibition of KRAS through Conformational Selection

ACS OMEGA

IF4.3

2023-08-18

OAAI

Pagba, Cynthia V.; Gupta, Amit K.; Gorfe, Alemayehu A.

AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2 AMPK和内皮型一氧化氮合酶信号通过环GMP依赖性蛋白激酶2调节k-ras质膜相互作用

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-17

OAAI

Cho, Kwang-jin; Casteel, Darren E.; Prakash, Priyanka; Tan, Lingxiao; van der Hoeven, Dharini; Salim, Angela A.; Kim, Choel; Capon, Robert J.; Lacey, Ernest; Cunha, Shane R.; Gorfe, Alemayehu A.; Hancock, John F.

Biophysics of cancer

BIOPHYSICAL JOURNAL

IF3.1

2022-10-01

OAAI

Gorfe, Alemayehu A.

KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement

ACS BIO & MED CHEM AU

IF4.3

2022-09-26

OAAI

Pagba, CynthiaV.; Gupta, Amit K.; Naji, Ali K.; van der Hoeven, Dharini; Churion, Kelly; Liang, Xiaowen; Jakubec, Jacob; Hook, Magnus; Zuo, Yan; Martinez de Kraatz, Marisela; Frost, Jeffrey A.; Gorfe, Alemayehu A.

Determinants of Membrane Orientation Dynamics in Lipid-Modified Small GTPases

JACS AU

IF8.7

2021-12-03

OAAI

Prakash, Priyanka; Gorfe, Alemayehu A.

Building insights into KRAS signaling complexes 构建对KRAS信号复合物的洞察

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2021-10-08

PREAI

Hancock, John F.; Gorfe, Alemayehu A.

RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2021-06-17

OAAI

Zhou, Yong; Gorfe, Alemayehu A.; Hancock, John F.

The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-02-01

OAAI

Zhou, Yong; Prakash, Priyanka S.; Liang, Hong; Gorfe, Alemayehu A.; Hancock, John F.

Transmembrane potential of physiologically relevant model membranes: Effects of membrane asymmetry

JOURNAL OF CHEMICAL PHYSICS

IF3.1

2020-09-08

OAAI

Lin, Xubo; Gorfe, Alemayehu A.

In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein

FUTURE MEDICINAL CHEMISTRY

IF3.4

2020-09-07

OAAI

Quah, Shun Ying; Tan, Michelle Siying; Ho, Kok Lian; Manan, Nizar Abdul; Gorfe, Alemayehu Abebe; Deb, Pran Kishore; Sagineedu, Sreenivasa Rao; Stanslas, Johnson

Intracellular Ca2+ regulation of H+/Ca2+ antiporter YfkE mediated by a Ca2+ mini-sensor Ca2微型传感器介导的H /Ca2反转运蛋白YfkE的细胞内Ca2调节

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-04-27

OAAI

Lu, Shuo; Li, Zhenlong; Gorfe, Alemayehu A.; Zheng, Lei

Membrane-Bound Ras as a Conformational Clock

BIOPHYSICAL JOURNAL

IF3.1

2020-03-01

OAAI

Gorfe, Alemayehu A.; Sligar, Stephen G.

Conformational spread and dynamics in allostery of NMDA receptors NMDA受体变构中的构象分布和动力学

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-02-03

OAAI

Durham, Ryan J.; Paudyal, Nabina; Carrillo, Elisa; Bhatia, Nidhi Kaur; Maclean, David M.; Berka, Vladimir; Dolino, Drew M.; Gorfe, Alemayehu A.; Jayaraman, Vasanthi

Dynamics of Membrane-Bound G12V-KRAS from Simulations and Single-Molecule FRET in Native Nanodiscs (vol 116, pg 179, 2019)

BIOPHYSICAL JOURNAL

IF3.1

2020-01-01

OAAI

Prakash, Priyanka; Litwin, Douglas; Liang, Hong; Sarkar-Banerjee, Suparna; Dolino, Drew; Zhou, Yong; Hancock, John F.; Jayaraman, Vasanthi; Gorfe, Alemayehu A.

Membrane curvature sensing of the lipid-anchored K-Ras small GTPase

LIFE SCIENCE ALLIANCE

IF2.9

2019-07-11

OAAI

Liang, Hong; Mu, Huanwen; Jean-Francois, Frantz; Lakshman, Bindu; Sarkar-Banerjee, Suparna; Zhuang, Yinyin; Zeng, Yongpeng; Gao, Weibo; Zaske, Ana Maria; Nissley, Dwight, V; Golfe, Alemayehu A.; Zhao, Wenting; Zhou, Yong

Multi-target, ensemble-based virtual screening yields novel allosteric KRAS inhibitors at high success rate 多靶点，基于集合的虚拟筛选以高成功率产生新型变构KRAS抑制剂

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2019-04-29

PREAI

Gupta, Amit K.; Wang, Xu; Pagba, Cynthia V.; Prakash, Priyanka; Sarkar-Banerjee, Suparna; Putkey, John; Gorfe, Alemayehu A.

研究方向