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PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Iannotta, Lucia; Fasiczka, Rachel; Favetta, Giulia; Zhao, Yibo; Giusto, Elena; Dall'Ara, Elena; Wei, Jianning; Ho, Franz Y.; Ciriani, Claudia; Cogo, Susanna; Tessari, Isabella; Iaccarino, Ciro; Liberelle, Maxime; Bubacco, Luigi; Taymans, Jean-Marc; Manzoni, Claudia; Kortholt, Arjan; Civiero, Laura; Hilfiker, Sabine; Lu, Michael L.; Greggio, Elisa 分享 收藏
PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation Iannotta, Lucia; Emanuele, Marco; Favetta, Giulia; Tombesi, Giulia; Vandewynckel, Laurine; Ordonez, Antonio Jesus Lara; Saliou, Jean-Michel; Drouyer, Matthieu; Sibran, William; Civiero, Laura; Nichols, R. Jeremy; Athanasopoulos, Panagiotis S.; Kortholt, Arjan; Chartier-Harlin, Marie-Christine; Greggio, Elisa; Taymans, Jean-Marc 分享 收藏
Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction 炎症通路诱导过程中人和小鼠小胶质细胞的物种特异性代谢重编程 Sabogal-Guaqueta, Angelica Maria; Marmolejo-Garza, Alejandro; Trombetta-Lima, Marina; Oun, Asmaa; Hunneman, Jasmijn; Chen, Tingting; Koistinaho, Jari; Lehtonen, Sarka; Kortholt, Arjan; Wolters, Justina C.; Bakker, Barbara M.; Eggen, Bart J. L.; Boddeke, Erik; Dolga, Amalia 分享 收藏
Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization Pathak, Pragya; Alexander, Krista K.; Helton, Leah G.; Kentros, Michalis; LeClair, Timothy J.; Zhang, Xiaojuan; Ho, Franz Y.; Moore, Timothy T.; Hall, Scotty; Guaitoli, Giambattista; Gloeckner, Christian Johannes; Kortholt, Arjan; Rideout, Hardy; Kennedy, Eileen J. 分享 收藏
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C2GAP2 is a common regulator of Ras signaling for chemotaxis, phagocytosis, and macropinocytosis Xu, Xuehua; Pots, Henderikus; Gilsbach, Bernd K.; Parsons, Dustin; Veltman, Douwe M.; Ramachandra, Sharmila G.; Li, Haoran; Kortholt, Arjan; Jin, Tian 分享 收藏
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A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively Marchand, Antoine; Sarchione, Alessia; Athanasopoulos, Panagiotis S.; Bauderlique-Le Roy, Helene; Goveas, Liesel; Magnez, Romain; Drouyer, Matthieu; Emanuele, Marco; Ho, Franz Y.; Liberelle, Maxime; Melnyk, Patricia; Lebegue, Nicolas; Thuru, Xavier; Nichols, R. Jeremy; Greggio, Elisa; Kortholt, Arjan; Galli, Thierry; Chartier-Harlin, Marie-Christine; Taymans, Jean-Marc 分享 收藏
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2 纳米抗体作为帕金森病相关LRRK2的变构调节剂 Singh, Ranjan K.; Soliman, Ahmed; Guaitoli, Giambattista; Stoermer, Eliza; von Zweydorf, Felix; Dal Maso, Thomas; Oun, Asmaa; Van Rillaer, Laura; Schmidt, Sven H.; Chatterjee, Deep; David, Joshua A.; Pardon, Els; Schwartz, Thomas U.; Knapp, Stefan; Kennedy, Eileen J.; Steyaert, Jan; Herberg, Friedrich W.; Kortholt, Arjan; Gloeckner, Christian Johannes; Versees, Wim 分享 收藏
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Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides Helton, Leah G.; Soliman, Ahmed; von Zweydorf, Felix; Kentros, Michalis; Manschwetus, Jascha T.; Hall, Scotty; Gilsbach, Bernd; Ho, Franz Y.; Athanasopoulos, Panagiotis S.; Singh, Ranjan K.; LeClair, Timothy J.; Versees, Wim; Raimondi, Francesco; Herberg, Friedrich W.; Gloeckner, Christian Johannes; Rideout, Hardy; Kortholt, Arjan; Kennedy, Eileen J. 分享 收藏
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Coordinated Ras and Rac Activity Shapes Macropinocytic Cups and Enables Phagocytosis of Geometrically Diverse Bacteria Buckley, Catherine M.; Pots, Henderikus; Gueho, Aurelie; Vines, James H.; Munn, Christopher J.; Phillips, Ben A.; Gilsbach, Bernd; Traynor, David; Nikolaev, Anton; Soldati, Thierry; Parnell, Andrew J.; Kortholt, Arjan; King, Jason S. 分享 收藏
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies Leemans, Margaux; Galicia, Christian; Deyaert, Egon; Daems, Elise; Krause, Linda; Paesmans, Jone; Pardon, Els; Steyaert, Jan; Kortholt, Arjan; Sobott, Frank; Klostermeier, Dagmar; Versees, Wim 分享 收藏
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