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Functional combinatorial precision medicine for predicting and optimizing soft tissue sarcoma treatments 功能性组合精准医学在软组织肉瘤治疗预测与优化中的应用 Chan, Sharon Pei Yi; Rashid, Masturah Bte Mohd Abdul; Lim, Jhin Jieh; Goh, Janice Jia Ni; Wong, Wai Yee; Hooi, Lissa; Ismail, Nur Nadiah; Luo, Baiwen; Chen, Benjamin Jieming; Noor, Nur Fazlin Bte Mohamed; Phua, Brandon Xuan Ming; Villanueva, Andre; Sam, Xin Xiu; Ong, Chin-Ann Johnny; Chia, Claramae Shulyn; Abidin, Suraya Zainul; Yong, Ming-Hui; Kumar, Krishan; Ooi, London Lucien; Tay, Timothy Kwang Yong; Woo, Xing Yi; Toh, Tan Boon; Yang, Valerie Shiwen; Chow, Edward Kai-Hua 分享 收藏
METTL8 links mt-tRNA m3C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity (vol 15, 338, 2024) Lee, Bernice Woon Li; Chuah, You Heng; Yoon, Jeehyun; Grinchuk, Oleg V.; Liang, Yajing; Hirpara, Jayshree L.; Shen, Yating; Wang, Loo Chien; Lim, Yan Ting; Zhao, Tianyun; Sobota, Radoslaw M.; Yeo, Tseng Tsai; Wong, Andrea Li Ann; Teo, Kejia; Nga, Vincent Diong Weng; Tan, Bryce Wei Quan; Suda, Toshio; Toh, Tan Boon; Pervaiz, Shazib; Lin, Zhewang; Ong, Derrick Sek Tong 分享 收藏
METTL8 links mt-tRNA m3C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity Lee, Bernice Woon Li; Chuah, You Heng; Yoon, Jeehyun; Grinchuk, Oleg V.; Liang, Yajing; Hirpara, Jayshree L.; Shen, Yating; Wang, Loo Chien; Lim, Yan Ting; Zhao, Tianyun; Sobota, Radoslaw M.; Yeo, Tseng Tsai; Wong, Andrea Li Ann; Teo, Kejia; Nga, Vincent Diong Weng; Tan, Bryce Wei Quan; Suda, Toshio; Toh, Tan Boon; Pervaiz, Shazib; Lin, Zhewang; Ong, Derrick Sek Tong 分享 收藏
Ex vivo Drug Testing Identifies a Novel Drug Pair in Targeting STS Chan, Sharon Pei Yi; Wong, Wai Yee; Ismail, Nur Nadiah; Luo, Baiwen; Chen, Benjamin Jieming; Phua, Brandon Xuan Ming; Woo, Xing Yi; Toh, Tan Boon; Chow, Edward Kai-Hua; Yang, Valerie Shiwen 分享 收藏
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METTL8-MEDIATED EPITRANSCRIPTOMIC REGULATION OF GBM CYCLING STATE IS DEPENDENT ON RTK/PI3K/AKT SIGNALING Lee, Bernice Woon Li; Chuah, You Heng; Yoon, Jeehyun; Grinchuk, Oleg V.; Feng, Jia; Liang, Yajing; Hirpara, Jayshree L.; Shen, Ya Ting; Wang, Loo Chien; Lim, Yan Ting; Zhao, Tianyun; Sobota, Radoslaw M.; Toh, Tan Boon; Pervaiz, Shazib; Lin, Zhewang; Ong, Derrick Sek Tong 分享 收藏
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Mitochondria-Targeting Type-I Photodrug: Harnessing Caspase-3 Activity for Pyroptotic Oncotherapy Yi, Zhigao; Qin, Xujuan; Zhang, Li; Chen, Huan; Song, Tianlin; Luo, Zichao; Wang, Tao; Lau, Junwei; Wu, Yelin; Toh, Tan Boon; Lee, Chun-Sing; Bu, Wenbo; Liu, Xiaogang 分享 收藏
A functional personalised oncology approach against metastatic colorectal cancer in matched patient derived organoids Thng, Dexter Kai Hao; Hooi, Lissa; Siew, Bei En; Lee, Kai-Yin; Tan, Ian Jse-Wei; Lieske, Bettina; Lin, Norman Sihan; Kow, Alfred Wei Chieh; Wang, Shi; Rashid, Masturah Bte Mohd Abdul; Ang, Chermaine; Koh, Jasmin Jia Min; Toh, Tan Boon; Tan, Ker-Kan; Chow, Edward Kai-Hua 分享 收藏
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Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer Thng, Dexter Kai Hao; Hooi, Lissa; Toh, Clarissa Chin Min; Lim, Jhin Jieh; Rajagopalan, Deepa; Syariff, Imran Qamar Charles; Tan, Zher Min; Abdul Rashid, Masturah Bte Mohd; Zhou, Lei; Kow, Alfred Wei Chieh; Bonney, Glenn Kunnath; Goh, Brian Kim Poh; Kam, Juinn Huar; Jha, Sudhakar; Dan, Yock Young; Chow, Pierce Kah Hoe; Toh, Tan Boon; Chow, Edward Kai-Hua 分享 收藏
Splice-switch oligonucleotide-based combinatorial platform prioritizes synthetic lethal targets CHK1 and BRD4 against MYC-driven hepatocellular carcinoma 基于剪接转换寡核苷酸的组合平台优先考虑针对MYC驱动的肝细胞癌的合成致死靶标CHK1和BRD4 Thng, Dexter Kai Hao; Toh, Tan Boon; Pigini, Paolo; Hooi, Lissa; Dan, Yock Young; Chow, Pierce Kah-Hoe; Bonney, Glenn Kunnath; Rashid, Masturah Bte Mohd Abdul; Guccione, Ernesto; Wee, Dave Keng Boon; Chow, Edward Kai-Hua 分享 收藏
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Hepatocellular carcinoma organoid co-cultures mimic angiocrine crosstalk to generate inflammatory tumor microenvironment* Lim, Joanne Tze Chin; Kwang, Leng Gek; Ho, Nicholas Ching Wei; Toh, Clarissa Chin Min; Too, Nathaniel Sheng Hua; Hooi, Lissa; Benoukraf, Touati; Chow, Pierce Kah-Hoe; Dan, Yock Young; Chow, Edward Kai-Hua; Toh, Tan Boon; Fong, Eliza Li Shan 分享 收藏
Targeting RNA editing of antizyme inhibitor 1: A potential oligonucleotide-based antisense therapy for cancer Tay, Daryl Jin Tai; Song, Yangyang; Peng, Boya; Toh, Tan Boon; Hooi, Lissa; Toh, Desiree-Faye Kaixin; Hong, HuiQi; Tang, Sze Jing; Han, Jian; Gan, Wei Liang; Chan, Tim Hon Man; Krishna, Manchugondanahalli S.; Patil, Kiran M.; Maraswami, Manikantha; Loh, Teck Peng; Dan, Yock Young; Zhou, Lei; Bonney, Glenn Kunnath; Chow, Pierce Kah-Hoe; Chen, Gang; Chow, Edward Kai-Hua; Le, Minh T. N.; Chen, Leilei 分享 收藏
A chemical biology approach reveals a dependency of glioblastoma on biotin distribution Yoon, Jeehyun; Grinchuk, Oleg, V; Kannan, Srinivasaraghavan; Ang, Melgious Jin Yan; Li, Zhenglin; Tay, Emmy Xue Yun; Lok, Ker Zhing; Lee, Bernice Woon Li; Chuah, You Heng; Chia, Kimberly; Magallanes, Roberto Tirado; Liu, Chenfei; Zhao, Haonan; Hor, Jin Hui; Lim, Jhin Jieh; Benoukraf, Touati; Toh, Tan Boon; Chow, Edward Kai-Hua; Kovalik, Jean-Paul; Ching, Jianhong; Ng, Shi-Yan; Koh, Ming Joo; Liu, Xiaogang; Verma, Chandra Shekhar; Ong, Derrick Sek Tong 分享 收藏
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