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Improved overall survival in an anti-PD-L1 treated cohort of newly diagnosed glioblastoma patients is associated with distinct immune, mutation, and gut microbiome features: a single arm prospective phase I/II trial 在抗PD-L1治疗的 Newly Diagnosed Glioblastoma 患者队列中，总体生存率的改善与特定的免疫、突变和肠道微生物组特征相关：一项单臂前瞻性I/II期试验 Weathers, Shiao-Pei; Li, Xiqi; Zhu, Haifeng; Damania, Ashish V.; Knafl, Mark; Mckinley, Brian; Lin, Heather; Harrison, Rebecca A.; Majd, Nazanin K.; O'Brien, Barbara J.; Penas-Prado, Marta; Loghin, Monica; Kamiya-Matsuoka, Carlos; Yung, W. K. Alfred; Soto, Luisa M. Solis; Maru, Dipen M.; Wistuba, Ignacio; Parra Cuentas, Edwin R.; Hernandez, Sharia; Futreal, Andrew; Wargo, Jennifer A.; Schulze, Katja; Darbonne, Walter C.; Ajami, Nadim J.; Woodman, Scott E.; de Groot, John F. 分享 收藏
EVALUATION OF PAXALISIB IN GBM AGILE PHASE 3 REGISTRATION PLATFORM TRIAL FOR NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA PAXALISIB在新诊断和复发胶质母细胞瘤的GBM敏捷3期注册平台试验中的评估 Mellinghoff, Ingo K.; Cloughesy, Timothy; Alexander, Brian; Berry, Donald A.; Buxton, Meredith; Cavenee, Webster; Colman, Howard; de Groot, John; Ellingson, Benjamin M.; Gordon, Gary B.; Lassman, Andrew B.; Lim, Michael; Khasraw, Mustafa; Perry, James; Sulman, Erik P.; Weller, Michael; Wen, Patrick; Yung, W. K. Alfred; Berry, Nicholas; Graves, Todd; Detry, Michelle; Hyddmark, E. M. Viktoria; Johnsson, Adam; Kling, Heather; Mcglothlin, Anna; Powell, Ashley; Untch, Sarah; Aquilanti, Elisa; Blondin, Nicholas; Boulmay, Brian; de la Fuente, Macarena; Drappatz, Jan; Jordan, Justin; Kaley, Thomas J.; Lobbous, Mina; Mikkelsen, Tom; Newton, Herbert; Owen, Scott; Peters, Katherine; Schiff, David; Sherman, Wendy; Weathers, Shiao-Pei; Youssef, Michael; Friend, John; Lee, Eudocia 分享 收藏
LONGITUDINAL SINGLE-CELL ANALYSES IDENTIFY DRIVERS OF GENETIC, EPIGENOMIC, AND CELLULAR EVOLUTION IN IDH-MUTANT GLIOMA Johnson, Kevin; Spitzer, Avishay; Varn, Frederick; Nomura, Masashi; Garofano, Luciano; Chowdhury, Tamrin; Anderson, Kevin; D'Angelo, Fulvio; Bussema, Lillian; Gritsch, Simon; Oh, Young Taek; Moon, Hyo-Eun; Paek, Sun Ha; Bielle, Franck; Laurenge, Alice; Di Stefano, Anna-Luisa; Mathon, Bertrand; Picca, Alberto; Sanson, Marc; Lipsa, Anuja; Hertel, Frank; Zhao, Zheng; Wang, Qianghu; Jiang, Tao; Hermes, Beth; Sanai, Nader; Golebiewska, Anna; Niclou, Simone; Huse, Jason; Yung, W. K. Alfred; Lasorella, Anna; Suva, Mario; Iavarone, Antonio; Tirosh, Itay; Verhaak, Roel 分享 收藏
GBM AGILE PLATFORM TRIAL FOR NEWLY DIAGNOSED AND RECURRENT GBM: RESULTS OF FIRST EXPERIMENTAL ARM, REGORAFENIB Lassman, A.; Alexander, B.; Berry, D.; Buxton, M.; Cavenee, W.; Colman, H.; De Groot, J.; Ellingson, B.; Gordon, G.; Hyddmark, E. M., V; Khasraw, M.; Lim, M.; Mellinghoff, I; Mikkelsen, T.; Perry, J.; Powell, A.; Sulman, E.; Tanner, K.; Weller, M.; Yung, W. K. A.; Blondin, N.; Brenner, A.; Butt, O.; de la Fuente, M., I; Drappatz, J.; Iwamoto, F.; Kim, L.; Lee, E.; Mantica, M.; Nabors, B.; Newton, H.; Schiff, D.; Walbert, T.; Weathers, S.; Cloughesy, T.; Wen, P. Y. 分享 收藏
A GLOBAL EXPANSION OF GBM AGILE: A PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA Weller, M.; Berry, D.; Blondin, N.; Boulmay, B.; Buxton, M.; Chinot, O.; Colman, H.; de la Fuente, M.; de Groot, J.; Drappatz, J.; Ducray, F.; Ellingson, B.; Galldiks, N.; Gordon, G.; Hau, P.; Hottinger, A.; Hyddmark, V; Khasraw, M.; Kim, L.; Lassman, A.; Lee, E.; Lim, M.; Mellinghoff, I; Mikkelson, T.; Nghiemphu, P.; Perry, J.; Ronellenfitsch, M.; Sulman, E.; Tabatabai, G.; Tanner, K.; Touat, M.; Wen, P. Y.; Wick, A.; Yung, W.; Cloughesy, T. 分享 收藏
LONGITUDINAL SINGLE-CELL ANALYSES IDENTIFY DRIVERS OF GENETIC, EPIGENOMIC, AND CELLULAR EVOLUTION IN IDH-MUTANT GLIOMA Johnson, K. C.; Spitzer, A.; Varn, F. S.; Nomura, M.; Garofano, L.; Chowdhury, T.; Anderson, K. J.; D'Angelo, F.; Bussema, L.; Gritsch, S.; Oh, Y.; Moon, H.; Paek, S.; Bielle, F.; Laurenge, A.; Di Stefano, A.; Mathon, B.; Picca, A.; Sanson, M.; Lipsa, A.; Hertel, F.; Zhao, Z.; Wang, Q.; Jiang, T.; Hermes, B.; Sanai, N.; Golebiewska, A.; Niclou, S. P.; Huse, J.; Yung, W.; Lasorella, A.; Suva, M. L.; Iavarone, A.; Tirosh, I; Verhaak, R. G. 分享 收藏
Neuronal differentiation drives the antitumor activity of mitogen-activated protein kinase kinase (MEK) inhibition in glioblastoma Khan, Sabbir; Martinez-Ledesma, Emmanuel; Dong, Jianwen; Mahalingam, Rajasekaran; Park, Soon Young; Piao, Yuji; Koul, Dimpy; Balasubramaniyan, Veerakumar; de Groot, John F.; Yung, W. K. Alfred 分享 收藏
GBM AGILE: A GLOBAL, PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE TREATMENT REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA Weller, M.; Ellingson, B.; Alexander, B.; Wen, P.; Sulman, E.; Colman, H.; Berry, D.; Tanner, K.; Khasraw, M.; Lim, M.; Perry, J.; Lassman, A.; Cloughesy, T.; Yung, W. K. A.; Lee, E. Q.; Mellinghoff, I.; Gordon, G.; de Groot, J.; Mikkelsen, T.; Cavenee, W.; Nelli, A.; Buxton, M.; Li, W. 分享 收藏
Hypothetical generalized framework for a new imaging endpoint of therapeutic activity in early phase clinical trials in brain tumors 脑肿瘤早期临床试验中治疗活动的新成像终点的假设广义框架 Ellingson, Benjamin M.; Gerstner, Elizabeth R.; Lassman, Andrew B.; Chung, Caroline; Colman, Howard; Cole, Patricia E.; Leung, David; Allen, Joshua E.; Ahluwalia, Manmeet S.; Boxerman, Jerrold; Brown, Matthew; Goldin, Jonathan; Nduom, Edjah; Hassan, Islam; Gilbert, Mark R.; Mellinghoff, Ingo K.; Weller, Michael; Chang, Susan; Arons, David; Meehan, Clair; Selig, Wendy; Tanner, Kirk; Yung, W. K. Alfred; van den Bent, Martin; Wen, Patrick Y.; Cloughesy, Timothy F. 分享 收藏
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Prioritization schema for immunotherapy clinical trials in glioblastoma Hodges, Tiffany R.; Ferguson, Sherise D.; Caruso, Hillary G.; Kohanbash, Gary; Zhou, Shouhao; Cloughesy, Timothy F.; Berger, Mitchel S.; Poste, George H.; Khasraw, Mustafa; Ba, Sujuan; Jiang, Tao; Mikkelson, Tom; Yung, W. K. Alfred; de Groot, John F.; Fine, Howard; Cantley, Lewis C.; Mellinghoff, Ingo K.; Mitchell, Duane A.; Okada, Hideho; Heimberger, Amy B. 分享 收藏
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Genomically amplified Akt3 activates DNA repair pathway and promotes glioma progression 基因组扩增的Akt3激活DNA修复通路并促进神经胶质瘤进展 Turner, Kristen M.; Sun, Youting; Ji, Ping; Granberg, Kirsi J.; Bernard, Brady; Hu, Limei; Cogdell, David E.; Zhou, Xinhui; Yli-Harja, Olli; Nykter, Matti; Shmulevich, Ilya; Yung, W. K. Alfred; Fuller, Gregory N.; Zhang, Wei 分享 收藏
Caveolin-mediated Tie2 nuclear translocation results in enhanced NHEJ repair and glioma radioresistance Hossain, Mohammad B.; Cortes-Santiago, Nahir; Fan, Xuejun; Gabrusiewicz, Konrad; Gumin, Joy; Sulman, Erik P.; Lang, Frederick; Sawaya, Raymond; Yung, W. K. Alfred; Fueyo, Juan; Gomez-Manzano, Candelaria 分享 收藏
Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma Penas-Prado, Marta; Hess, Kenneth R.; Fisch, Michael J.; Lagrone, Lore W.; Groves, Morris D.; Levin, Victor A.; De Groot, John F.; Puduvalli, Vinay K.; Colman, Howard; Volas-Redd, Gena; Giglio, Pierre; Conrad, Charles A.; Salacz, Michael E.; Floyd, Justin D.; Loghin, Monica E.; Hsu, Sigmund H.; Gonzalez, Javier; Chang, Eric L.; Woo, Shiao Y.; Mahajan, Anita; Aldape, Kenneth D.; Yung, W. K. Alfred; Gilbert, Mark R. 分享 收藏
PHASE II TRIAL OF THE PHOSPHATIDYINOSITOL-3 KINASE (PI3K) INHIBITOR BUPARLISIB (BKM120) IN RECURRENT GLIOBLASTOMA CONDUCTED BY THE IVY FOUNDATION EARLY PHASE CLINICAL TRIALS CONSORTIUM Wen, Patrick Y.; Wen, Patrick Y.; Yung, W. K. Alfred; Mellinghoff, Ingo K.; Ramkissoon, Shakti; Alexander, Brian; Rinne, Mikael; Colman, Howard; Omuro, Antonio M.; DeAngelis, Lisa M.; Gilbert, Mark R.; DeGroot, John; Cloughesy, Timothy F.; Lee, Eudocia Q.; Nayak, Lakshmi; Chi, Andrew S.; Batchelor, Tracy; Chang, Susan M.; Prados, Michael D.; Reardon, David A.; Ligon, Keith L. 分享 收藏
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