未登录 Focused ultrasound-mediated blood-brain barrier disruption, combined with antigen-presenting cell activation, promotes CNS antigen-specific T cell immunity and bypasses immunotherapy resistance mechanism in malignant brain tumors 聚焦超声介导的血脑屏障破坏，结合抗原提呈细胞激活，促进中枢神经系统抗原特异性T细胞免疫，并绕过恶性脑肿瘤的免疫疗法耐药机制。 Gallus, Marco; Yamamichi, Akane; Arrieta, Victor Andres; Nejo, Takahide; Phung, Lan; Saijo, Atsuro; Chuntova, Pavlina; Lu, Jianwen; Phyu, Su; Zhao, Aishi; Okada, Kaori; Watchmaker, Payal; Haegelin, Jeffrey; Lakshmanachetty, Senthilnath; Habashy, Karl; Canney, Michael; Sonabend, Adam M.; Okada, Hideho 分享 收藏
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Comparative evaluation of CAR-expressing T-, NK-, NKT-cells, and macrophages in an immunocompetent mouse glioma model CAR表达T细胞、NK细胞、NKT细胞及巨噬细胞在免疫健全小鼠胶质瘤模型中的比较评估 Hatae, Ryusuke; Watchmaker, Payal B.; Yamamichi, Akane; Kyewalabye, Keith; Okada, Kaori; Phyu, Su; Goretsky, Yitzhar; Haegelin, Jeffrey; Pineo-Cavanaugh, Psalm; Gallus, Marco; Phung, Lan; Chen, Tiffany; Long, Haoyu; Chuntova, Pavlina; Raulet, David H.; Terabe, Masaki 分享 收藏
MICROBUBBLE-ENHANCED FOCUSED ULTRASOUND REGULATES THE ENRICHMENT OF INFLAMMATORY PATHWAYS IN THE BLOOD-BRAIN BARRIER AND IMPROVES CAR T CELL ACCUMULATION IN GLIOMAS Arvanitis, Costas; Guo, Yutong; Lee, Hohyun; Kim, Chulyong; Park, Christian; Yamamichi, Akane; Chuntova, Pavlina; Gallus, Marco; Bernabeu, Miguel O.; Jo, Hanjoong; Okada, Hideho 分享 收藏
LOW-INTENSITY PULSED ULTRASOUND COMBINED WITH POLY-ICLC AND INTERLEUKIN-2 UNLOCKS THE IMMUNE PRIVILEGE OF THE BRAIN BY PROMOTING EPITOPE SPREADING AND ACTIVATION OF CNS-SPECIFIC NAÏVE T CELLS 低强度脉冲超声联合poly-iclc和INTERLEUKIN-2通过促进CNS特异性初始T细胞的表位扩散和激活来解锁大脑的免疫特权 Gallus, Marco; Yamamichi, Akane; Arrieta, Victor Andres; Saijo, Atsuro; Chuntova, Pavlina; Phyu, Su; Phung, Lan; Haegelin, Jeffrey; Long, Haoyu; Lakshmanachetty, Senthilnath; Nejo, Takahide; Okada, Kaori; Chen, Li; Habashy, Karl; Gould, Andrew; Amidei, Christina; Chang, Catalina Lee; Stupp, Roger; Canney, Michael; Sonabend, Adam M.; Okada, Hideho 分享 收藏
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T-CELL THERAPY COMBINED WITH LOW-INTENSITY PULSED FOCUSED ULTRASOUND, MICROBUBBLES AND POLY-ICLC PROMOTES THE PRESENTATION OF BRAIN-DERIVED ANTIGENS, BREAKING CNS TOLERANCE AND INDUCING ACTIVE T-CELL RESPONSES Gallus, M.; Yamamichi, A.; Arrieta, V. Andres; Saijo, A.; Chuntova, P.; Haegelin, J.; Phyu, S.; Phung, L.; Long, J.; Lakshmanachetty, S.; Nejo, T.; Okada, K.; Chen, L.; Habashy, K.; Gould, A.; Amidei, C.; Chang, C.; Stupp, R.; Canney, M.; Sonabend, A.; Okada, H. 分享 收藏
Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier Guo, Yutong; Lee, Hohyun; Kim, Chulyong; Park, Christian; Yamamichi, Akane; Chuntova, Pavlina; Gallus, Marco; Bernabeu, Miguel O.; Okada, Hideho; Jo, Hanjoong; Arvanitis, Costas 分享 收藏
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Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment Hatae, Ryusuke; Kyewalabye, Keith; Yamamichi, Akane; Chen, Tiffany; Phyu, Su; Chuntova, Pavlina; Nejo, Takahide; Levine, Lauren S.; Spitzer, Matthew H.; Okada, Hideho 分享 收藏
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Low-intensity pulsed ultrasound enhances the presentation of brain-derived antigens by facilitating the migration of antigen-presenting cells from the brain to the periphery Gallus, Marco; Arrieta, Victor Andres; Saijo, Atsuro; Chuntova, Pavlina; Yamamichi, Akane; Haegelin, Jeffrey; Phyu, Su; Phung, Lan; Amir-Kabirian, Shayan A.; Lakshmanachetty, Senthilnath; Chen, Li; Habashy, Karl; Gould, Andrew; Amidei, Christina; Chang, Catalina Lee; Stupp, Roger; Canney, Michael; Okada, Hideho 分享 收藏
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Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice Chuntova, Pavlina; Hou, Yafei; Naka, Ryosuke; Yamamichi, Akane; Chen, Tiffany; Goretsky, Yitzhar; Hatae, Ryusuke; Nejo, Takahide; Kohanbash, Gary; Mende, Abigail L.; Montoya, Megan; Downey, Kira M.; Diebold, David; Skinner, Jayne; Liang, Hong-Erh; Schwer, Bjoern; Okada, Hideho 分享 收藏
Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma 深度免疫分析揭示免疫检查点抑制剂难治性胶质母细胞瘤免疫逃避的靶向机制 Simonds, Erin F.; Lu, Edbert D.; Badillo, Oscar; Karimi, Shokoufeh; Liu, Eric, V; Tamaki, Whitney; Rancan, Chiara; Downey, Kira M.; Stultz, Jacob; Sinha, Meenal; McHenry, Lauren K.; Nasholm, Nicole M.; Chuntova, Pavlina; Sundstrom, Anders; Genoud, Vassilis; Shahani, Shilpa A.; Wang, Leo D.; Brown, Christine E.; Walker, Paul R.; Swartling, Fredrik J.; Fong, Lawrence; Okada, Hideho; Weiss, William A.; Hellstrom, Mats 分享 收藏
Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neurooncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank Chuntova, Pavlina; Chow, Frances; Watchmaker, Payal B.; Galvez, Mildred; Heimberger, Amy B.; Newell, Evan W.; Diaz, Aaron; DePinho, Ronald A.; Li, Ming O.; Wherry, E. John; Mitchell, Duane; Terabe, Masaki; Wainwright, Derek A.; Berzofsky, Jay A.; Herold-Mende, Christel; Heath, James R.; Lim, Michael; Margolin, Kim A.; Chiocca, E. Antonio; Kasahara, Noriyuki; Ellingson, Benjamin M.; Brown, Christine E.; Chen, Yvonne; Fecci, Peter E.; Reardon, David A.; Dunn, Gavin P.; Liau, Linda M.; Costello, Joseph F.; Wick, Wolfgang; Cloughesy, Timothy; Timmer, William C.; Wen, Patrick Y.; Prins, Robert M.; Platten, Michael; Okada, Hideho 分享 收藏
JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors Irey, Emily A.; Lassiter, Chelsea M.; Brady, Nicholas J.; Chuntova, Pavlina; Wang, Ying; Knutson, Todd P.; Henzler, Christine; Chaffee, Thomas S.; Vogel, Rachel I.; Nelson, Andrew C.; Farrar, Michael A.; Schwertfeger, Kathryn L. 分享 收藏
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Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy Chheda, Zinal S.; Kohanbash, Gary; Okada, Kaori; Jahan, Naznin; Sidney, John; Pecoraro, Matteo; Yang, Xinbo; Carrera, Diego A.; Downey, Kira M.; Shrivastav, Shruti; Liu, Shuming; Lin, Yi; Lagisetti, Chetana; Chuntova, Pavlina; Watchmaker, Payal B.; Mueller, Sabine; Pollack, Ian F.; Rajalingam, Raja; Carcaboso, Angel M.; Mann, Matthias; Sette, Alessandro; Garcia, K. Christopher; Hou, Yafei; Okada, Hideho 分享 收藏
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