未登录 CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity Hwang, Bin-Jin; Crosby, Erika J.; Severson, David T.; Trotter, Timothy N.; McBane, Jason; Tsao, Li-Chung; Wang, Tao; Liu, Cong-Xiao; Yang, Xiao-Yi; Lei, Gangjun; Wei, Junping; Ma, Xingru; Liu, Bushanqing; Hobeika, Amy; Morse, Michael; Joseph, Jesuchristopher; Agritelley, Ethan; Kanu, Elishama; Comatas, Karrie; Keler, Tibor; He, Li-Zhen; Lyerly, Herbert Kim; Hartman, Zachary C. 分享 收藏
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mTOR inhibition modulates vaccine-induced immune responses to generate memory T cells in patients with solid tumors mTOR抑制调节疫苗诱导的免疫应答以在实体瘤患者中产生记忆T细胞 Withers, Henry G.; Matsuzaki, Junko; Long, Mark; Rosario, Spencer R.; Chodon, Thinle; Tsuji, Takemasa; Koya, Richard; Yan, Li; Wang, Jianming; Keler, Tibor; Lele, Shashikant B.; Zsiros, Emese; Lugade, Amit; Hutson, Alan; Blank, Stephanie; Bhardwaj, Nina; Shrikant, Protul; Liu, Song; Odunsi, Kunle 分享 收藏
Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX-622 使用一种新型双特异性抗体CDX-622对肥大细胞和胸腺基质淋巴细胞生成素的联合抑制 Murphy, Michael B.; Vitale, Laura; O'Neill, Thomas; Maurer, Deena M.; Malenchek, Linda; Crocker, Andrea; Patterson, Colleen; Mills-Chen, Laura; Saley, Virginia; Antczak, Nicole M.; Boyer, James M.; Mcmanus, Kelly M.; Montanari, Noe Rico; Hammond, Russell A.; Goldstein, Joel; Thomas, Lawrence J.; Keler, Tibor; Alvarado, Diego 分享 收藏
Phase 1b study of maintenance soluble beta-glucan (Odetiglucan) in combination with a CD40 agonistic monoclonal antibody (CDX-1140) in patients with metastatic pancreatic adenocarcinoma that had not progressed on first-line chemotherapy O'Hara, Mark H.; Wattenberg, Max; Garrido-Laguna, Ignacio; O'Reilly, Eileen M.; Yellin, Michael; Keler, Tibor; Gargano, Michele; Niles, Nick; Drees, Jeremy; Bose, Nandita; Beatty, Gregory L. 分享 收藏
Phase 1b study of maintenance soluble beta-glucan (Odetiglucan) in combination with a CD40 agonistic monoclonal antibody (CDX-1140) in patients with metastatic pancreatic adenocarcinoma that had not progressed on first-line chemotherapy O'Hara, Mark H.; Wattenberg, Max; Garrido-Laguna, Ignacio; O'Reilly, Eileen M.; Yellin, Michael; Keler, Tibor; Gargano, Michele; Niles, Nick; Drees, Jeremy; Bose, Nandita; Beatty, Gregory L. 分享 收藏
Enhancing the strength and durability of vaccine-induced anti-tumor immunity with CD27 agonism of CD4+T cells Hwang, Bin-Jin; Crosby, Erika; Trotter, Timothy; Tsao, Li-Chung; Wang, Tao; Liu, Congxiao; Yang, Xiao; Lei, Gangjun; Wei, Junping; Ma, Xingru; Liu, Bushanqing; Hobeika, Amy; Morse, Michael; Keler, Tibor; He, Li-Zhen; Lyerly, Herbert Kim; Hartman, Zachary 分享 收藏
The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis Englebert, Kevin; Taquin, Anaelle; Azouz, Abdulkader; Acolty, Valerie; Vande Velde, Sylvie; Vanhollebeke, Marie; Innes, Hadrien; Boon, Louis; Keler, Tibor; Leo, Oberdan; Goriely, Stanislas; Moser, Muriel; Oldenhove, Guillaume 分享 收藏
A combinatory vaccine with IMA950 plus varlilumab promotes effector memory T-cell differentiation in the peripheral blood of patients with low-grade gliomas Saijo, Atsuro; Ogino, Hirokazu; Butowski, Nicholas A.; Tedesco, Meghan R.; Gibson, David; Watchmaker, Payal B.; Okada, Kaori; Wang, Albert S.; Shai, Anny; Salazar, Andres M.; Molinaro, Annette M.; Rabbitt, Jane E.; Shahin, Maryam; Perry, Arie; Clarke, Jennifer L.; Taylor, Jennie W.; Daras, Mariza; Oberheim Bush, Nancy Ann; Hervey-Jumper, Shawn L.; Phillips, Joanna J.; Chang, Susan M.; Hilf, Norbert; Mayer-Mokler, Andrea; Keler, Tibor; Berger, Mitchel S.; Okada, Hideho 分享 收藏
CDX-585, a novel bispecific antibody targeting PD-1 and ILT4 Thomas, Lawrence J.; Vitale, Laura A.; Murphy, Michael; Xia, Collin; Peng, Zeyu; Ejas, Asma; Patel, Montu; Boyer, James; Baronas, April R.; O'Neill, Thomas; Widger, Jenifer; Mills-Chen, Laura; Crocker, Andrea; Ma, Mark; Chen, Mingjiu; Davis, Hugh M.; Hammond, Russ A.; Taglienti, Cherie; Yellin, Michael; Goldstein, Joel; Alvarado, Diego; Marsh, Henry C.; Keler, Tibor 分享 收藏
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Tissue-specific modifier alleles determine Mertk loss-of-function traits Akalu, Yemsratch T.; Mercau, Maria E.; Ansems, Marleen; Hughes, Lindsey D.; Nevin, James; Alberto, Emily J.; Liu, Xinran N.; He, Li-Zhen; Alvarado, Diego; Keler, Tibor; Kong, Yong; Philbrick, William M.; Bosenberg, Marcus; Finnemann, Silvia C.; Iavarone, Antonio; Lasorella, Anna; Rothlin, Carla, V; Ghosh, Sourav 分享 收藏
Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering 激动性CD27抗体效力由通过Fc工程增强的表位依赖性受体聚类决定 Heckel, Franziska; Turaj, Anna H.; Fisher, Hayden; Chan, H. T. Claude; Marshall, Michael J. E.; Dadas, Osman; Penfold, Christine A.; Inzhelevskaya, Tatyana; Mockridge, C. Ian; Alvarado, Diego; Tews, Ivo; Keler, Tibor; Beers, Stephen A.; Cragg, Mark S.; Lim, Sean H. 分享 收藏
Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study Alvarado, Diego; Maurer, Marcus; Gedrich, Richard; Seibel, Scott B.; Murphy, Michael B.; Crew, Linda; Goldstein, Joel; Crocker, Andrea; Vitale, Laura A.; Morani, Pamela A.; Thomas, Lawrence J.; Hawthorne, Thomas R.; Keler, Tibor; Young, Diane; Crowley, Elizabeth; Kankam, Martin; Heath-Chiozzi, Margo 分享 收藏
HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin Biondini, Marco; Kiepas, Alex; El-Houjeiri, Leeanna; Nis, Matthew G. An; Hsu, Brian E.; Fortier, Anne-Marie; Morin, Genevieve; Martina, Jose A.; Sirois, Isabelle; Aguilar-Mahecha, Adriana; Gruosso, Tina; McGuirk, Shawn; Rose, April A. N.; Tokat, Unal M.; Johnson, Radia M.; Sahin, Ozgur; Bareke, Eric; St-Pierre, Julie; Park, Morag; Basik, Mark; Majewski, Jacek; Puertollano, Rosa; Pause, Arnim; Huang, Sidong; Keler, Tibor; Siegel, Peter M. 分享 收藏
Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets Flt3配体通过扩大树突状细胞亚群增强对anti-DEC-205-NY-ESO-1疫苗的免疫反应 Bhardwaj, Nina; Friedlander, Philip A.; Pavlick, Anna C.; Ernstoff, Marc S.; Gastman, Brian R.; Hanks, Brent A.; Curti, Brendan D.; Albertini, Mark R.; Luke, Jason J.; Blazquez, Ana B.; Balan, Sreekumar; Bedognetti, Davide; Beechem, Joseph M.; Crocker, Andrea S.; D'Amico, Leonard; Danaher, Patrick; Davis, Thomas A.; Hawthorne, Thomas; Hess, Bruce W.; Keler, Tibor; Lundgren, Lisa; Morishima, Chihiro; Ramchurren, Nirasha; Rinchai, Darawan; Salazar, Andres M.; Salim, Bob A.; Sharon, Elad; Vitale, Laura A.; Wang, Ena; Warren, Sarah; Yellin, Michael J.; Disis, Mary L.; Cheever, Martin A.; Fling, Steven P. 分享 收藏
CDX1140-01, A PHASE 1 DOSE-ESCALATION/EXPANSION STUDY OF CDX-1140 ALONE (PART 1) AND IN COMBINATION WITH CDX-301 (PART 2) OR PEMBROLIZUMAB (PART 3) Sanborn, Rachel; Hauke, Ralph; Gabrail, Nashat; O'Hara, Mark; Bhardwaj, Nina; Bordoni, Rodolfo; Gordon, Michael; Khalil, Danny; Abdelrahim, Maen; Marron, Thomas; Hawthorne, Thomas; Thomas, Lawrence; Rawls, Tracey; Rogalski, Mark; Alvarado, Diego; Vitale, Laura; Keler, Tibor; Yellin, Michael 分享 收藏
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