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Kevin P. Cole

Eli Lilly

32H指数
112论文数
3.2K被引数
收录论文 46
发表时间
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part I: Synthesis of the Pyridazinyl Imidazolidinone Intermediate Enabled by Biocatalysis and CSTR Technologies
err2025-04-01
err1
PREAI
errYang, Qiang; Lu, Yu; Beauchamp, Thomas J.; Cole, Kevin P.; Wang, Jiang; Gangula, Srinivas; Zhang, Silong; Cui, Zhaoshan; Wang, Guopeng; Shi, Lei; Jing, Dajiang; Wei, Fuliang; Jiao, Xuecheng; Li, Xiang; Zhang, Na; Jiang, Xiangjun; Ma, Yulei
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Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754
err2025-03-01
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PREAI
errBeauchamp, Thomas J.; Cole, Kevin P.; Broughton, Howard B.; Coates, David A.; Cumming, Graham Robert; de Diego, Jose Eugenio; Frimpong, Kwame; Gutierrez, Julio; Holloway, William; Hotham, Ian; Jones, Spencer; Kaoudi, Talbi; Lander, Peter; Levinson, Adam M.; Lu, Yu; Lugar, Charles; Partridge, Katherine; Ruble, J. Craig; Saouane, Sofiane; Ummaneni, Narasimha Rao; Vandeveer, H. George; Watson, Brian
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Risk Assessment and Control of N-Nitrosamines in Antibody-Drug Conjugates: Current Industry Practices抗体-药物结合物中N-亚硝胺的风险评估和控制: 当前行业惯例
err2024-07-30
err1
PREAI
errBulger, Paul G.; Jones, Michael T.; Ford, J. Gair; Schrier, Kate; Cole, Kevin P.; Bernardoni, Frank; Dirat, Olivier; Zhang, Qunying; Chahrour, Osama; Miller, Joy; Bonaga, Llorente; Parsons, Andrew T.; Yang, Lan
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Risk Evaluation of N-Nitrosamines in Drug-Linker Intermediates Used To Generate Antibody-Drug Conjugates用于产生抗体-药物偶联物的药物-接头中间体中N-亚硝胺的风险评估
err2024-07-25
err1
PREAI
errChahrour, Osama; Bulger, Paul G.; Dirat, Olivier; Schrier, Kate; Parsons, Andrew T.; Ford, J. Gair; Bernardoni, Frank; Hetrick, Evan M.; Bonaga, Llorente R.; Cole, Kevin P.; Miller, Joy; Zhang, Qunying; Jones, Michael T.
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Flow Chemistry and Continuous Processing: More Mainstream than Ever!
err2024-05-17
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errOAAI
errCole, Kevin P.; Jaworski, Jonathan N.; Kappe, C. Oliver; Kobayashi, Shu; Maguire, Anita R.; O'Kearney-McMullan, Anne; Pesti, Jaan A.
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Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation药物开发中的光化学: 全行业实施策略和方法的调查
err2024-03-08
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PREAI
errMoschetta, Eric G.; Cook, Gemma C.; Edwards, Lee J.; Ischay, Michael A.; Lei, Zhen; Buono, Frederic; Levesque, Francois; Garber, Jeffrey A. O.; MacTaggart, Maura; Sezen-Edmonds, Melda; Cole, Kevin P.; Beaver, Matthew G.; Doerfler, Jaika; Opalka, Suzanne M.; Liang, Wenli; Morse, Peter D.; Miyake, Naomi
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Solid potential
err2021-04-19
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PREAI
errKerr, Mark S.; Cole, Kevin P.
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Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
err2020-09-22
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PREAI
errRichardson, Jeffery; Cole, Kevin P.; DeBaillie, Amy C.; Hao, Junliang; Piper, Jared; Houghton, Peter; Rizzo, John; Jia, Mo; Liu, Peng; Huang, Ping; Kadlecikova, Katarina; Garcia, Conchita F.; Richards, Daniel S.
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Development and Production of an Enantioselective Tetrahydroisoquinoline Synthesis Enabled by Continuous Cryogenic Lithium-Halogen Exchange通过连续低温锂-卤素交换实现的对映选择性四氢异喹啉合成的开发和生产
err2020-04-22
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PREAI
errCole, Kevin P.; Argentine, Mark D.; Conder, Edward W.; Vaid, Radhe K.; Feng, Pengyao; Jia, Mo; Huang, Ping; Liu, Peng; Sun, Baoquan; Tadayon, Sam; Zhu, Cheng; Zhu, Ruiheng
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Small-Volume Continuous Manufacturing of Merestinib. Part 2. Technology Transfer and cGMP Manufacturing小批量连续生产梅里替尼。第二部分。技术转让和cGMP制造
err2019-03-12
err33
errOAAI
errReizman, Brandon J.; Cole, Kevin P.; Hess, Molly; Burt, Justin L.; Maloney, Todd D.; Johnson, Martin D.; Laurila, Michael E.; Cope, Richard F.; Luciani, Carla V.; Buser, Jonas Y.; Campbell, Bradley M.; Forst, Mindy B.; Mitchell, David; Braden, Timothy M.; Lippelt, Christopher K.; Boukerche, Moussa; Starkey, Derek R.; Miller, Richard D.; Chen, Jing; Sun, Baoquan; Kwok, Martin; Zhang, Xin; Tadayon, Sam; Huang, Ping
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Small-Volume Continuous Manufacturing of Merestinib. Part 1. Process Development and Demonstration小批量连续生产梅里替尼。第一部分。工艺开发和演示
err2019-03-12
err42
PREAI
errCole, Kevin P.; Reizman, Brandon J.; Hess, Molly; Groh, Jennifer M.; Laurila, Michael E.; Cope, Richard F.; Campbell, Bradley M.; Forst, Mindy B.; Burt, Justin L.; Maloney, Todd D.; Johnson, Martin D.; Mitchell, David; Polster, Christopher S.; Mitra, Aurpon W.; Boukerche, Moussa; Conder, Edward W.; Braden, Timothy M.; Miller, Richard D.; Heller, Michael R.; Phillips, Joseph L.; Howell, John R.
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An Alternative Indazole Synthesis for Merestinib
err2018-02-21
err9
PREAI
errLu, Yu; Cole, Kevin P.; Fennell, Jared W.; Maloney, Todd D.; Mitchell, David; Subbiah, Ramesh; Ramadas, Balakumar
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Reagent-free continuous thermal tert-butyl ester deprotection无试剂连续热叔丁酯脱保护
err2017-12-01
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PREAI
errCole, Kevin P.; Ryan, Sarah J.; Groh, Jennifer McClary; Miller, Richard D.
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An automated repeating batch with catalyst recycle approach to nitro group hydrogenolysis
err2017-01-01
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PREAI
errCole, Kevin P.; Johnson, Martin D.; Laurila, Michael E.; Stout, James R.
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Photochemical Perfluoroalkylation with Pyridine N-Oxides: Mechanistic Insights and Performance on a Kilogram Scale
errCHEM
IF19.6
err2016-09-01
err220
errOAAI
errBeatty, Joel W.; Douglas, James J.; Miller, Richard; McAtee, Rory C.; Cole, Kevin P.; Stephenson, Corey R. J.
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