Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second BromodomainJOURNAL OF MEDICINAL CHEMISTRYIF6.82020-04-2397PREAI
Discovery of ABBV-744, a first-in-class highly BDII-selective BET bromodomain inhibitorCANCER RESEARCHIF16.62018-07-013PRE
Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530)JOURNAL OF MEDICINAL CHEMISTRYIF6.82018-04-1345PREAI
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral BioavailabilityJOURNAL OF MEDICINAL CHEMISTRYIF6.82018-01-2517PREAI
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain InhibitorJOURNAL OF MEDICINAL CHEMISTRYIF6.82017-10-12125PREAI
Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic StrategiesCANCER RESEARCHIF16.62017-05-31113OAAI
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain InhibitorsJOURNAL OF MEDICINAL CHEMISTRYIF6.82017-04-2159OAAI
ABBV-075, a novel BET family bromodomain inhibitor, represents a promising therapeutic agent for a broad spectrum of cancer indicationsCANCER RESEARCHIF16.62016-07-1510PRE
Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075CANCER RESEARCHIF16.62016-07-150PRE
Discovery of ABT-267, a Pan-Genotypic Inhibitor of HCV NS5AJOURNAL OF MEDICINAL CHEMISTRYIF6.82014-01-15122PREAI
PRECLINICAL CHARACTERIZATION OF ABT-072: A NOVEL NON-NUCLEOSIDE HCV POLYMERASE INHIBITORJOURNAL OF HEPATOLOGYIF332009-04-014OAAI
Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Biological Characterization of Unsymmetrical Dialkyl-Hydroxynaphthalenoyl-benzothiadiazinesJOURNAL OF MEDICINAL CHEMISTRYIF6.82009-02-1817PREAI
Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitroANTIMICROBIAL AGENTS AND CHEMOTHERAPYIF4.52005-10-01123OAAI
Nonsteroidal selective glucocorticoid modulators: The effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolinesJOURNAL OF MEDICINAL CHEMISTRYIF6.82003-02-19113PREAI
Nonsteroidal selective glucocorticoid modulators: The effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolinesJOURNAL OF MEDICINAL CHEMISTRYIF6.82001-11-10120PREAI
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole α1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasiaJOURNAL OF MEDICINAL CHEMISTRYIF6.82001-05-1129PREAI
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