Keith F. McDaniel

AbbVie

H指数:23

被引数:2,160

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工作经历

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荣誉奖项

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Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia

MOLECULAR CANCER THERAPEUTICS

IF5.5

2021-07-1224

Zhang, Lu; Cai, Tianyu; Lin, Xiaoyu; Huang, Xiaoli; Bui, Mai H.; Plotnik, Joshua P.; Bellin, Richard J.; Faivre, Emily J.; Kuruvilla, Vinitha M.; Lam, Lloyd T.; Lu, Xin; Zha, Zheng; Feng, Weiguo; Hessler, Paul; Uziel, Tamar; Zhang, Qi; Cavazos, Antonio; Han, Lina; Ferguson, Debra C.; Mehta, Gaurav; Shanmugavelandy, Sriram S.; Magoc, Terrance J.; Rowe, Jenny; Goodwin, Neal C.; Dorritie, Kathleen A.; Boyiadzis, Michael; Albert, Daniel H.; McDaniel, Keith F.; Kati, Warren M.; Konopleva, Marina; Shen, Yu

Novel Physics-Based Ensemble Modeling Approach That Utilizes 3D Molecular Conformation and Packing to Access Aqueous Thermodynamic Solubility: A Case Study of Orally Available Bromodomain and Extraterminal Domain Inhibitor Lead Optimization Series

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2021-03-0416

Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-04-2397

PREAI

Acute myeloid leukemia human/mouse co-clinical trial feasibility study optimized in human transgenic IL-3/GMCSF NOD/Shi-scid-IL2rnull mice

CANCER RESEARCH

IF16.6

2018-07-010

PRE

First-in-class, highly BDII-selective BET family inhibitor ABBV-744 displays potent anti-tumor activity in androgen receptor positive prostate cancer models and an improved tolerability profile

CANCER RESEARCH

IF16.6

2018-07-013

PRE

ABBV-744, a first-in-class and highly selective inhibitor of the second bromodomain of BET family proteins, displays robust activities in preclinical models of acute myelogenous leukemia

CANCER RESEARCH

IF16.6

2018-07-014

PRE

Discovery of ABBV-744, a first-in-class highly BDII-selective BET bromodomain inhibitor

CANCER RESEARCH

IF16.6

2018-07-013

PRE

Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-05-3115

PREAI

In Vitro Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS3/4A Protease Inhibitor Glecaprevir

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2018-01-0169

OAAI

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-10-12125

PREAI

McDaniel, Keith F.; Wang, Le; Soltwedel, Todd; Fidanze, Steven D.; Hasvold, Lisa A.; Liu, Dachun; Mantei, Robert A.; Pratt, John K.; Sheppard, George S.; Bui, Mai H.; Faivre, Emily J.; Huang, Xiaoli; Li, Leiming; Lin, Xiaoyu; Wang, Rongqi; Warder, Scott E.; Wilcox, Denise; Albert, Daniel H.; Magoc, Terrance J.; Rajaraman, Ganesh; Park, Chang H.; Hutchins, Charles W.; Shen, Jianwei J.; Edalji, Rohinton P.; Sun, Chaohong C.; Martin, Ruth; Gao, Wenqing; Wong, Shekman; Fang, Guowei; Elmore, Steven W.; Shen, Yu; Kati, Warren M.

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies

CANCER RESEARCH

IF16.6

2017-05-31113

OAAI

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-04-2159

OAAI

Wang, Le; Pratt, John K.; Soltwedel, Todd; Sheppard, George S.; Fidanze, Steven D.; Liu, Dachun; Hasvold, Lisa A.; Mantei, Robert A.; Holms, James H.; McClellan, William J.; Wendt, Michael D.; Wada, Carol; Frey, Robin; Hansen, T. Matthew; Hubbard, Robert; Park, Chang H.; Li, Leiming; Magoc, Terrance J.; Albert, Daniel H.; Lin, Xiaoyu; Warder, Scott E.; Kovar, Peter; Huang, Xiaoli; Wilcox, Denise; Wang, Rongqi; Rajaraman, Ganesh; Petros, Andrew M.; Hutchins, Charles W.; Panchal, Sanjay C.; Sun, Chaohong; Elmore, Steven W.; Shen, Yu; Kati, Warren M.; McDaniel, Keith F.

HEXIM1 as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues

MOLECULAR CANCER THERAPEUTICS

IF5.5

2017-02-0252

OAAI

Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075

MOLECULAR CANCER RESEARCH

IF4.7

2017-01-0352

OAAI

The BET family bromodomain inhibitor ABBV-075 is a promising therapeutic agent for acute myeloid leukemia and myelodysplastic syndrome

CANCER RESEARCH