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Kota Toshimoto

RIKEN

H指数:16

被引数:580

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\Physiologically-based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2023-09-042

OAAI

Improved Prediction of the Drug-Drug Interactions of Pemafibrate Caused by Cyclosporine A and Rifampicin via PBPK Modeling: Consideration of the Albumin-Mediated Hepatic Uptake of Pemafibrate and Inhibition Constants With Preincubation Against OATP1B

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2021-01-013

PREAI

Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2021-01-0112

OAAI

A Simple Decision Tree Suited for Identification of Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation

一种简单的决策树，适用于通过肠道CYP3A饱和度识别可能具有药代动力学非线性的早期口服候选药物

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2021-01-010

OAAI

Physiologically-Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2019-03-1931

OAAI

Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake

提高三种降糖药肝内在清除率预测准确性的策略: 应用扩展清除率概念并考虑白蛋白对CYP2C代谢和OATP1B-mediated肝摄取的影响

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2018-12-0117

PREAI

PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2018-09-3063

OAAI

In Silico Prediction of Major Clearance Pathways of Drugs among 9 Routes with Two-Step Support Vector Machines

PHARMACEUTICAL RESEARCH

IF4.3

2018-08-2412

PREAI

Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype-Guided Dosing of Tamoxifen

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2018-06-1910

OA

Comprehensive PBPK Model of Rifampicin for Quantitative Prediction of Complex Drug-Drug Interactions: CYP3A/2C9 Induction and OATP Inhibition Effects

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2018-02-0551

OAAI

Analysis of Nonlinear Pharmacokinetics of a Highly Albumin-Bound Compound: Contribution of Albumin-Mediated Hepatic Uptake Mechanism

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2017-09-0131

OAAI

Is Ethnic Variability in the Exposure to Rosuvastatin Explained Only by Genetic Polymorphisms in OATP1B1 and BCRP or Should the Contribution of Intrinsic Ethnic Differences in OATP1B1 Be Considered?

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2017-09-0110

OAAI

Quantitative Analysis of Complex DrugeDrug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2017-09-0117

OAAI

Analysis of the Change in the Blood Concentration-Time Profile Caused by Complex Drug-Drug Interactions in the Liver Considering the Enterohepatic Circulation: Examining Whether the Inhibition Constants for Uptake, Metabolism, and Biliary Excretion Can be Recovered by the Analyses Using Physiologically Based Pharmacokinetic Modeling

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2017-09-016

OAAI

Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects

PHARMACEUTICAL RESEARCH

IF4.3

2017-04-1018

OAAI

Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure

开发基于支持向量机的系统，以使用其化学结构预测化合物是否是给定药物转运蛋白的底物

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2016-07-0112

OAAI