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Georgia B. McGaughey

vertex pharmaceuticals

33H指数
100论文数
4.7K被引数
收录论文 37
发表时间
Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
err2023-01-10
err14
errOAAI
errLayton, Mark E.; Kern, Jeffrey C.; Hartingh, Timothy J.; Shipe, William D.; Raheem, Izzat; Kandebo, Monika; Hayes, Robert P.; Huszar, Sarah; Eddins, Donnie; Ma, Bennett; Fuerst, Joy; Wollenberg, Gordon K.; Li, Jing; Fritzen, Jeff; McGaughey, Georgia B.; Uslaner, Jason M.; Smith, Sean M.; Coleman, Paul J.; Cox, Christopher D.
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] Smallest Maximum Intramolecular Distance: A Novel Method to Mitigate Pregnane Xenobiotic Receptor Activation
err2020-03-04
err1
PREAI
errBower, Michael J.; Aronov, Alex M.; Cleveland, Thomas; Hariparsad, Niresh; McGaughey, Georgia B.; McMasters, Daniel R.; Zhang, Xiaodan; Goldman, Brian
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D3R grand challenge 4: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies
err2020-01-23
err63
errOAAI
errParks, Conor D.; Gaieb, Zied; Chiu, Michael; Yang, Huanwang; Shao, Chenghua; Walters, W. Patrick; Jansen, Johanna M.; McGaughey, Georgia; Lewis, Richard A.; Bembenek, Scott D.; Ameriks, Michael K.; Mirzadegan, Tara; Burley, Stephen K.; Amaro, Rommie E.; Gilson, Michael K.
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A Brief Recent History of Women in Computational Chemistry at Vertex Pharmaceuticals
err2019-01-08
err6
PREAI
errMcGaughey, Georgia; Swett, Rebecca; Swift, Sara; Chudyk, Ewa; Wong, Kathryn
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Computational Chemistry: A Rising Tide of Women
err2018-04-06
err9
PREAI
errHolloway, M. Katharine; McGaughey, Georgia B.
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Collaborating to improve the use of free-energy and other quantitative methods in drug discovery
err2016-12-24
err47
PREAI
errSherborne, Bradley; Shanmugasundaram, Veerabahu; Cheng, Alan C.; Christ, Clara D.; DesJarlais, Renee L.; Duca, Jose S.; Lewis, Richard A.; Loughney, Deborah A.; Manas, Eric S.; McGaughey, Georgia B.; Peishoff, Catherine E.; van Vlijmen, Herman
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Prediction of Protein Pairs Sharing Common Active Ligands Using Protein Sequence, Structure, and Ligand Similarity
err2016-09-02
err23
errOAAI
errChen, Yu-Chen; Tolber, Robert; Aronov, Alex M.; McGaughey, Georgia; Walters, W. Patrick; Meireles, Lidio
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Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis
err2015-09-25
err52
PREAI
errShipe, William D.; Sharik, Steven S.; Barrow, James C.; McGaughey, Georgia B.; Theberge, Cory R.; Uslaner, Jason M.; Yan, Youwei; Renger, John J.; Smith, Sean M.; Coleman, Paul J.; Cox, Christopher D.
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Shaping suvorexant: application of experimental and theoretical methods for driving synthetic designs
err2014-02-01
err18
errOAAI
errMcGaughey, Georgia; Bayly, Christopher I.; Cox, Christopher D.; Schreier, John D.; Breslin, Michael J.; Bogusky, Michael; Pitzenberger, Steve; Ball, Richard; Coleman, Paul J.
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Antiviral Activity and In Vitro Mutation Development Pathways of MK-6186, a Novel Nonnucleoside Reverse Transcriptase Inhibitor
err2012-06-01
err13
errOAAI
errLu, Meiqing; Felock, Peter J.; Munshi, Vandna; Hrin, Renee C.; Wang, Ying-Jie; Yan, Youwei; Munshi, Sanjeev; McGaughey, Georgia B.; Gomez, Robert; Anthony, Neville J.; Williams, Theresa M.; Grobler, Jay A.; Hazuda, Daria J.; McKenna, Philip M.; Miller, Michael D.; Lai, Ming-Tain
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Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties
err2012-02-03
err121
PREAI
errColeman, Paul J.; Schreier, John D.; Cox, Christopher D.; Breslin, Michael J.; Whitman, David B.; Bogusky, Michael J.; McGaughey, Georgia B.; Bednar, Rodney A.; Lemaire, Wei; Doran, Scott M.; Fox, Steven V.; Garson, Susan L.; Gotter, Anthony L.; Harrell, C. Meacham; Reiss, Duane R.; Cabalu, Tamara D.; Cui, Donghui; Prueksaritanont, Thomayant; Stevens, Joanne; Tannenbaum, Pamela L.; Ball, Richard G.; Stellabott, Joyce; Young, Steven D.; Hartman, George D.; Winrow, Christopher J.; Renger, John J.
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Design and Synthesis of Conformationally Constrained Inhibitors of Non-Nucleoside Reverse Transcriptase
err2011-10-28
err37
PREAI
errGomez, Robert; Jolly, Samson J.; Williams, Theresa; Vacca, Joseph P.; Torrent, Maricel; McGaughey, Georgia; Lai, Ming-Tain; Felock, Peter; Munshi, Vandna; DiStefano, Daniel; Flynn, Jessica; Miller, Mike; Yan, Youwei; Reid, John; Sanchez, Rosa; Liang, Yuexia; Paton, Brenda; Wan, Bang-Lin; Anthony, Neville
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Small Molecule Mimetics of an HIV-1 gp41 Fusion Intermediate as Vaccine Leads
err2010-12-01
err8
errOAAI
errCaulfield, Michael J.; Dudkin, Vadim Y.; Ottinger, Elizabeth A.; Getty, Krista L.; Zuck, Paul D.; Kaufhold, Robin M.; Hepler, Robert W.; McGaughey, Georgia B.; Citron, Michael; Hrin, Renee C.; Wang, Ying-Jie; Miller, Michael D.; Joyce, Joseph G.
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Distinct Mutation Pathways of Non-Subtype B HIV-1 during In Vitro Resistance Selection with Nonnucleoside Reverse Transcriptase Inhibitors
err2010-11-01
err36
errOAAI
errLai, Ming-Tain; Lu, Meiqing; Felock, Peter J.; Hrin, Renee C.; Wang, Ying-Jie; Yan, Youwei; Munshi, Sanjeev; McGaughey, Georgia B.; Tynebor, Robert M.; Tucker, Thomas J.; Williams, Theresa M.; Grobler, Jay A.; Hazuda, Daria J.; McKenna, Philip M.; Miller, Michael D.
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Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia
err2010-06-21
err365
PREAI
errCox, Christopher D.; Breslin, Michael J.; Whitman, David B.; Schreier, John D.; McGaughey, Georgia B.; Bogusky, Michael J.; Roecker, Anthony J.; Mercer, Swati P.; Bednar, Rodney A.; Lemaire, Wei; Bruno, Joseph G.; Reiss, Duane R.; Harrell, C. Meacham; Murphy, Kathy L.; Garson, Susan L.; Doran, Scott M.; Prueksaritanont, Thomayant; Anderson, Wayne B.; Tang, Cuyue; Roller, Shane; Cabalu, Tamara D.; Cui, Donahui; Hartman, George D.; Young, Steven D.; Koblan, Ken S.; Winrow, Christopher J.; Renger, John J.; Coleman, Paul J.
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Molecular Shape and Medicinal Chemistry: A Perspective
err2010-05-27
err281
errOAAI
errNicholls, Anthony; McGaughey, Georgia B.; Sheridan, Robert P.; Good, Andrew C.; Warren, Gregory; Mathieu, Magali; Muchmore, Steven W.; Brown, Scott P.; Grant, J. Andrew; Haigh, James A.; Nevins, Neysa; Jain, Ajay N.; Kelley, Brian
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Discovery of 4,4-Disubstituted Ouinazolin-2-ones as T-Type Calcium Channel Antagonists4,4-二取代Ouinazolin-2-ones作为T型钙通道拮抗剂的发现
err2010-02-01
err41
errOAAI
errBarrow, James C.; Rittle, Kenneth E.; Reger, Thomas S.; Yang, Zhi-Qiang; Bondiskey, Phung; McGaughey, Georgia B.; Bock, Mark G.; Hartman, George D.; Tang, Cuyue; Ballard, Jeanine; Kuo, Yuhsin; Prueksaritanont, Thomayant; Nuss, Cindy E.; Doran, Scott M.; Fox, Steven V.; Garson, Susan L.; Kraus, Richard L.; Li, Yuxing; Marino, Michael J.; Graufelds, Valerie Kuzmick; Uebele, Victor N.; Renger, John J.
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Structure and Modeling in the Design of β- and γ-Secretase Inhibitors
err2009-03-19
err29
PREAI
errHolloway, M. Katharine; Hunt, Peter; McGaughey, Georgia B.
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Evolution of Tertiary Carbinamine BACE-1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing
err2009-01-05
err19
PREAI
errNantermet, Philippe G.; Rajapakse, Hemaka A.; Stanton, Mathew G.; Stauffer, Shaun R.; Barrow, James C.; Gregro, Allison R.; Moore, Keith P.; Steinbeiser, Melissa A.; Swestock, John; Selnick, Harold G.; Graham, Samuel L.; McGaughey, Georgia B.; Colussi, Dennis; Lai, Ming-Tain; Sankaranarayanan, Sethu; Simon, Adam J.; Munshi, Sanieev; Cook, Jacquelynn J.; Holahan, Marie A.; Michener, Maria S.; Vacca, Joseph P.
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