未登录 Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma Visser, Michael; Papillon, Julien P. N.; Luzzio, Michael; Lamarche, Matthew J.; Fan, Jianmei; Michael, Walter; Wang, David; Zhang, Alan; Straub, Christopher; Mathieu, Simon; Kato, Mitsunori; Palermo, Mark; Chen, Christine; Ramsey, Timothy; Joud, Carol; Barrett, Rosemary; Vattay, Anthony; Guo, Ribo; Bric, Anka; Chung, Franklin; Liang, Guiqing; Romanowski, Michael J.; Lam, Joni; Thohan, Sanjeev; Atassi, Faraj; Wylie, Andrew; Cooke, Vesselina G. 分享 收藏
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Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8 Remillard, David; Savage, Nikolas A.; Kedves, Alexia T.; Paulk, Joshiawa; Chen, Xin; Garcia, Francisco J.; Romanowski, Michael J.; Horton, Patricia A.; Murphy, Jason; Schirle, Markus; Harrington, Edmund M.; Maxwell, Matthew B.; Pham, Helen Trinh; Maksimovic, Igor; Thomas, Jason R.; Forrester, William C. 分享 收藏
Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors Hopkins, Brian T.; Bame, Eris; Bell, Noah; Bohnert, Tonika; Bowden-Verhoek, Jon K.; Bui, Minna; Cancilla, Mark T.; Conlon, Patrick; Cullen, Patrick; Erlanson, Daniel A.; Fan, Junfa; Fuchs-Knotts, Tarra; Hansen, Stig; Heumann, Stacey; Jenkins, Tracy J.; Gua, Chuck; Liu, Ying; Liu, YuTing; Lulla, Mukush; Marcotte, Douglas; Marx, Isaac; McDowell, Bob; Mertsching, Elisabeth; Negrou, Ella; Romanowski, Michael J.; Scott, Daniel; Silvian, Laura; Yang, Wenjin; Zhong, Min 分享 收藏
Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens Hopkins, Brian T.; Bame, Eris; Bell, Noah; Bohnert, Tonika; Bowden-Verhoek, Jon K.; Bui, Minna; Cancilla, Mark T.; Conlon, Patrick; Cullen, Patrick; Erlanson, Daniel A.; Fan, Junfa; Fuchs-Knotts, Tarra; Hansen, Stig; Heumann, Stacey; Jenkins, Tracy J.; Marcotte, Douglas; McDowell, Bob; Mertsching, Elisabeth; Negrou, Ella; Otipoby, Kevin L.; Poreci, Urjana; Romanowski, Michael J.; Scott, Daniel; Silvian, Laura; Yang, Wenjin; Zhong, Min 分享 收藏
A small-molecule inhibitor of C5 complement protein Jendza, Keith; Kato, Mitsunori; Salcius, Michael; Srinivas, Honnappa; De Erkenez, Andrea; Nguyen, Anh; McLaughlin, Doug; Be, Celine; Wiesmann, Christian; Murphy, Jason; Bolduc, Philippe; Mogi, Muneto; Duca, Jose; Namil, Abdel; Capparelli, Michael; Darsigny, Veronique; Meredith, Erik; Tichkule, Ritesh; Ferrara, Luciana; Heyder, Jessica; Liu, Fang; Horton, Patricia A.; Romanowski, Michael J.; Schirle, Markus; Mainolfi, Nello; Anderson, Karen; Michaud, Gregory A. 分享 收藏
Structure of lipoprotein lipase in complex with GPIHBP1 Arora, Rishi; Nimonkar, Amitabh V.; Baird, Daniel; Wang, Chunhua; Chiu, Chun-Hao; Horton, Patricia A.; Hanrahan, Susan; Cubbon, Rose; Weldon, Stephen; Tschantz, William R.; Mueller, Sascha; Brunner, Reto; Lehr, Philipp; Meier, Peter; Ottl, Johannes; Voznesensky, Andrei; Pandey, Pramod; Smith, Thomas M.; Stojanovic, Aleksandar; Flyer, Alec; Benson, Timothy E.; Romanowski, Michael J.; Trauger, John W. 分享 收藏
Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1β Luksch, Hella; Romanowski, Michael J.; Chara, Osvaldo; Tuengler, Victoria; Caffarena, Ernesto R.; Heymann, Michael C.; Lohse, Peter; Aksentijevich, Ivona; Remmers, Elaine F.; Flecks, Silvana; Quoos, Nadine; Gramatte, Johannes; Petzold, Cathleen; Hofmann, Sigrun R.; Winkler, Stefan; Pessler, Frank; Kallinich, Tilmann; Ganser, Gerd; Nimtz-Talaska, Antje; Baumann, Ulrich; Runde, Volker; Grimbacher, Bodo; Birmelin, Jennifer; Gahr, Manfred; Roesler, Joachim; Roesen-Wolff, Angela 分享 收藏
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Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis Bonanno, JB; Edo, C; Eswar, N; Pieper, U; Romanowski, MJ; Ilyin, V; Gerchman, SE; Kycia, H; Studier, FW; Sali, A; Burley, SK 分享 收藏
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