未登录 A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, Peter; Glaser, Stefan P.; Han, Jing; Popa, Alexandra; Pisarsky, Laura; Feng, Ningping; Geyer, Antonia; Haderk, Franziska; Alpar, Donat; Bristow, Christopher; Schmittner, Susanne; Traexler, Paula-Elena; Mahendra, Mikhila; Poehn, Birgit; Gandhi, Poojabahen; Fiorelli, Roberto; Awate, Sanket; Budano, Nicole; Martin, Florian; Albrecht, Christoph; Drobits-Handl, Barbara; Anand, Sathanandam S.; Kasturirangan, Srinath; Trapani, Francesca; Schweifer, Norbert; Marszalek, Joseph R.; Tontsch-Grunt, Ulrike; Pearson, Mark; Heffernan, Timothy P.; Kraut, Norbert; Vellano, Christopher P.; Garcia-Martinez, Juan Manuel 分享 收藏
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KRASmulti inhibition and checkpoint targeting therapy show strong combination potential in KRAS wild-type and KRASG12V-driven syngeneic mouse models of pancreatic cancer Ebner, F.; Krolo, A.; Artemov, A.; Hubmann, M.; Hajto, A.; Oslislok, M.; Baumann, I.; Egermann, W.; Chylinski, K.; Tedeschi, A.; Lipp, J.; Kraut, N.; Pearson, M.; Pisarsky, L.; Rudolph, D.; Aichinger, M. 分享 收藏
KRASmulti inhibitor BI 3706674 shows efficacy in KRAS-driven preclinical models of cancer that supports clinical testing in patients with tumors harboring KRASG12V mutations and KRAS wild-type amplifications Tedeschi, A.; Peng, D. H.; Schischlik-Siegl, F.; Schaaf, O.; Gerlach, D.; Rocchetti, F.; Popow, J.; Broeker, J.; Wunberg, T.; Boghossian, A. S.; Rees, M. G.; Ronan, M. M.; Roth, J. A.; Williams, M.; Vellano, C.; Marszalek, J. R.; Heffernan, T. P.; Pearson, M.; Kraut, N.; Dorothea, R. 分享 收藏
Structure-based PROTAC design demonstrates BAF complex ATPase vulnerabilities in cancer Koegl, Manfred; Farnaby, William; Whitworth, Claire; Roy, Michael; Diers, Emelyne; Trainor, Nicole; Steurer, Steffen; Riedmueller, Carina; Gmaschitz, Teresa; Wachter, Johannes; Dank, Christian; Gallant, Michael; Sharps, Bernadette; Rumpel, Klaus; Traxler, Elisabeth; Lorenz, Romario; Petermann, Oliver; Greb, Peter; Weinstabl, Harald; Bader, Gerd; Zoephel, Andreas; Weiss-Puxbaum, Alexander; Rinnenthal, Joerg; Arnnhof, Heribert; Wiechens, Nicola; Wu, Meng-Ying; Owen-Hughes, Tom; Ettmayer, Peter; Pearson, Mark; McConnell, Darryl B.; Ciulli, Alessio 分享 收藏
SMARCA4 is a selective vulnerability in SMARCA2-deficient esophageal squamous cell carcinoma cell lines Ehrenhoefer-Woelfer, Katharina; Puchner, Teresa; Blaha-Ostermann, Silvia; Hoermann, Alexandra; Sommergruber, Wolfgang; Schweifer, Norbert; Zichner, Thomas; Schlattl, Andreas; Neumueller, Ralph A.; Koegl, Manfred; Petronczki, Mark P.; Pearson, Mark; Woehrle, Simon 分享 收藏
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