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Phase 1, randomized trials of MEDI1341: cerebrospinal fluid free α-synuclein lowered by >50% 第一阶段，MEDI1341的随机试验：脑脊液中游离α-突触蛋白降低>50% Shering, Craig; Pomfret, Michael; Kubiak, Robert J.; Pouliquen, Isabelle J.; Yin, Wei; Simen, Arthur; Ratti, Elena; Hussain, Zubair; Perkinton, Michael; Tan, Keith; Scott, Kirsten M.; Ostenfeld, Thor; Chessell, Iain 分享 收藏
MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non-clinical species and Alzheimer's disease patients Lloyd, Christopher; Freskgard, Per-Ola; Newton, Philip; Lowne, David; Nickson, Adrian; Bogstedt, Anna; Eketjall, Susanna; Hoglund, Kina; Gustavsson, Susanne; Welsh, Fraser; Chessell, Tharani; McFarlane, Mary; Bhat, Ratan V.; Turner, Richard; Perkinton, Michael S.; Santisteban Valencia, Zulma; Lindqvist, Eva; Pomfret, Michael; Dudley, Amanda D.; Vaughan, Tristan J.; Groves, Maria T.; Natanegara, Fanni; Feng, Yingdong; Sims, John R.; Proctor, Nicholas Kyle; Dage, Jeffrey L.; Shering, Craig; Tan, Keith; Ostenfeld, Thor; Billinton, Andy; Chessell, Iain P. 分享 收藏
Tau protein profiling in tauopathies: a human brain study Lantero-Rodriguez, Juan; Camporesi, Elena; Montoliu-Gaya, Laia; Gobom, Johan; Piotrowska, Diana; Olsson, Maria; Burmann, Irena Matecko; Becker, Bruno; Brinkmalm, Ann; Burmann, Bjorn M.; Perkinton, Michael; Ashton, Nicholas J.; Fox, Nick C.; Lashley, Tammaryn; Zetterberg, Henrik; Blennow, Kaj; Brinkmalm, Gunnar 分享 收藏
Pharmacokinetics of AAV9 Mediated Trastuzumab Expression in Rat Brain Following Systemic and Local Administration Chowdhury, Ekram Ahmed; Ahuja, Manuj; Wu, Shengjia; Liu, Shufang; Huang, Hsien Wei; Kumar, Mokshada; Sunkara, Kiran Sai; Ghobrial, Avanobe; Chandran, Jayanth; Jamier, Tanguy; Perkinton, Michael; Meno-Tetang, Guy; Shah, Dhaval K. 分享 收藏
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P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes Beltran-Lobo, Paula; Hughes, Martina M.; Troakes, Claire; Croft, Cara L.; Rupawala, Huzefa; Jutzi, Daniel; Ruepp, Marc-David; Jimenez-Sanchez, Maria; Perkinton, Michael S.; Kassiou, Michael; Golde, Todd E.; Hanger, Diane P.; Verkhratsky, Alexei; Perez-Nievas, Beatriz G.; Noble, Wendy 分享 收藏
Reducing α-Synuclein in Human CSF; An Evaluation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MEDI1341, an α-Synuclein-specific antibody, in Healthy Volunteers and Parkinson's Disease Patients Shering, Craig; Pomfret, Michael; Kubiak, Robert; Pouliquen, Isabelle; Yin, Wei; Simen, Arthur; Ratti, Elena; Perkinton, Michael; Tan, Keith; Chessell, Iain; Ostenfeld, Thor 分享 收藏
New Therapeutics in Alzheimer's Disease Longitudinal Cohort study (NTAD): study protocol Lanskey, Juliette Helene; Kocagoncu, Ece; Quinn, Andrew J.; Cheng, Yun-Ju; Karadag, Melek; Pitt, Jemma; Lowe, Stephen; Perkinton, Michael; Raymont, Vanessa; Singh, Krish D.; Woolrich, Mark; Nobre, Anna C.; Henson, Richard N.; Rowe, James B. 分享 收藏
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins Corbett, Grant T.; Wang, Zemin; Hong, Wei; Colom-Cadena, Marti; Rose, Jamie; Liao, Meichen; Asfaw, Adhana; Hall, Tia C.; Ding, Lai; DeSousa, Alexandra; Frosch, Matthew P.; Collinge, John; Harris, David A.; Perkinton, Michael S.; Spires-Jones, Tara L.; Young-Pearse, Tracy L.; Billinton, Andrew; Walsh, Dominic M. 分享 收藏
Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo Schofield, Darren J.; Irving, Lorraine; Calo, Laura; Bogstedt, Anna; Rees, Gareth; Nuccitelli, Annalisa; Narwal, Rajesh; Petrone, Marcella; Roberts, Jennifer; Brown, Lee; Cusdin, Fiona; Dosanjh, Bhupinder; Lloyd, Christopher; Dobson, Claire; Gurrell, Ian; Fraser, Graham; McFarlane, Mary; Rockenstein, Edward; Spencer, Brian; Masliah, Eliezer; Spillantini, Maria Grazia; Tan, Keith; Billinton, Andrew; Vaughan, Tris; Chessell, Iain; Perkinton, Michael S. 分享 收藏
Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo 可溶性tau聚集体在体内抑制突触长期抑制和淀粉样蛋白 β 促进的LTD Ondrejcak, Tomas; Hu, Neng-Wei; Qi, Yingjie; Klyubin, Igor; Corbett, Grant T.; Fraser, Graham; Perkinton, Michael S.; Walsh, Dominic M.; Billinton, Andrew; Rowan, Michael J. 分享 收藏
Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease Chen, Zhicheng; Mengel, David; Keshavan, Ashvini; Rissman, Robert A.; Billinton, Andrew; Perkinton, Michael; Percival-Alwyn, Jennifer; Schultz, Aaron; Properzi, Michael; Johnson, Keith; Selkoe, Dennis J.; Sperling, Reisa A.; Patel, Purvish; Zetterberg, Henrik; Galasko, Douglas; Schott, Jonathan M.; Walsh, Dominic M. 分享 收藏
Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy Lionnet, Arthur; Wade, Matthew A.; Corbille, Anne-Gaelle; Prigent, Alice; Paillusson, Sebastien; Tasselli, Maddalena; Gonzales, Jacques; Durieu, Emilie; Rolli-Derkinderen, Malvyne; Coron, Emmanuel; Duchalais, Emilie; Neunlist, Michel; Perkinton, Michael S.; Hanger, Diane P.; Noble, Wendy; Derkinderen, Pascal 分享 收藏
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Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures Croft, Cara L.; Wade, Matthew A.; Kurbatskaya, Ksenia; Mastrandreas, Pavlina; Hughes, Martina M.; Phillips, Emma C.; Pooler, Amy M.; Perkinton, Michael S.; Hanger, Diane P.; Noble, Wendy 分享 收藏
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