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A novel interleukin-10 antibody graft to treat inflammatory bowel disease 一种新型白细胞介素-10抗体嫁接物用于治疗炎症性肠病 Didonato, Michael; Simpson, Carolina Turk; Vo, Todd; Knuth, Mark; Geierstanger, Bernhard; Jamontt, Joanna; Jones, David H.; Fathman, John W.; Delarosa, Donnie; Junt, Tobias; Picard, Damien; Sommer, Ulrike; Bagger, Morten; Peters, Eric; Meeusen, Shelly; Spraggon, Glen 分享 收藏
Discovery of small molecules that target a tertiary-structured RNA 发现靶向三级结构RNA的小分子 Menichelli, Elena; Lam, Bianca J.; Wang, Yu; Wang, Vivian S.; Shaffer, Jennifer; Tjhung, Katrina F.; Bursulaya, Badry; Truc Ngoc Nguyen; Vo, Todd; Alper, Phillip B.; McAllister, Christopher S.; Jones, David H.; Spraggon, Glen; Michellys, Pierre-Yves; Joslin, John; Joyce, Gerald F.; Rogers, Jeff 分享 收藏
Identification of a PCSK9-LDLR disruptor peptide with in vivo function Brousseau, Margaret E.; Clairmont, Kevin B.; Spraggon, Glen; Flyer, Alec N.; Golosov, Andrei A.; Grosche, Philipp; Amin, Jakal; Andre, Jerome; Burdick, Debra; Caplan, Shari; Chen, Guanjing; Chopra, Raj; Ames, Lisa; Dubiel, Diana; Fan, Li; Gattlen, Raphael; Kelly-Sullivan, Dawn; Koch, Alexander W.; Lewis, Ian; Li, Jingzhou; Liu, Eugene; Lubicka, Danuta; Marzinzik, Andreas; Nakajima, Katsumasa; Nettleton, David; Ottl, Johannes; Pan, Meihui; Patel, Tajesh; Perry, Lauren; Pickett, Stephanie; Poirier, Jennifer; Reid, Patrick C.; Pelle, Xavier; Seepersaud, Mohindra; Subramanian, Vanitha; Vera, Victoria; Xu, Mei; Yang, Lihua; Yang, Qing; Yu, Jinghua; Zhu, Guoming; Monovich, Lauren G. 分享 收藏
Structure-Based Design of Selective LONP1 Inhibitors for Probing In Vitro Biology Kingsley, Laura J.; He, Xiaohui; McNeill, Matthew; Nelson, John; Nikulin, Victor; Ma, Zhiwei; Lu, Wenshuo; Zhou, Vicki W.; Manuia, Mari; Kreusch, Andreas; Gao, Mu-Yun; Witmer, Darbi; Vaillancourt, Mei-Ting; Lu, Min; Greenblatt, Sarah; Lee, Christian; Vashisht, Ajay; Bender, Steven; Spraggon, Glen; Michellys, Pierre-Yves; Jia, Yong; Haling, Jacob R.; Lelais, Gerald 分享 收藏
Biochemical Characterization of Respiratory Syncytial Virus RNA-Dependent RNA Polymerase Complex Balakrishnan, Anand; Price, Edmund; Luu, Catherine; Shaul, Jacob; Wartchow, Charles; Cantwell, John; Vo, Todd; DiDonato, Michael; Spraggon, Glen; Hekmat-Nejad, Mohammad 分享 收藏
Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases Nagle, Advait; Biggart, Agnes; Be, Celine; Srinivas, Honnappa; Hein, Andreas; Caridha, Diana; Sciotti, Richard J.; Pybus, Brandon; Kreishman-Deitrick, Mara; Bursulaya, Badry; Lai, Yin H.; Gao, Mu-Yun; Liang, Fang; Mathison, Casey J. N.; Liu, Xiaodong; Yeh, Vince; Smith, Jeffrey; Lerario, Isabelle; Xie, Yongping; Chianelli, Donatella; Gibney, Michael; Berman, Ashley; Chen, Yen-Liang; Jiricek, Jan; Davis, Lauren C.; Liu, Xianzhong; Ballard, Jaime; Khare, Shilpi; Eggimann, Fabian Kurt; Luneau, Alexandre; Groessl, Todd; Shapiro, Michael; Richmond, Wendy; Johnson, Kevin; Rudewicz, Patrick J.; Rao, Srinivasa P. S.; Thompson, Christopher; Tuntland, Tove; Spraggon, Glen; Glynne, Richard J.; Supek, Frantisek; Wiesmann, Christian; Molteni, Valentina 分享 收藏
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Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases He, Xiaohui; Da Ros, Sara; Nelson, John; Zhu, Xuefeng; Jiang, Tao; Okram, Barun; Jiang, Songchun; Michellys, Pierre-Yves; Iskandar, Maya; Espinola, Sheryll; Jia, Yong; Bursulaya, Badry; Kreusch, Andreas; Gao, Mu-Yun; Spraggon, Glen; Baaten, Janine; Clemmer, Leah; Meeusen, Shelly; Huang, David; Hill, Robert; Van Nguyen-Tran; Fathman, John; Liu, Bo; Tuntland, Tove; Gordon, Perry; Hollenbeck, Thomas; Ng, Kenneth; Shi, Jian; Bordone, Laura; Liu, Hong 分享 收藏
Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers Lelais, Gerald; Epple, Robert; Marsilje, Thomas H.; Long, Yun O.; McNeill, Matthew; Chen, Bei; Lu, Wenshuo; Anumolu, Jaganmohan; Badiger, Sangamesh; Bursulaya, Badry; DiDonato, Michael; Fong, Rina; Juarez, Jose; Li, Jie; Manuia, Mari; Mason, Daniel E.; Gordon, Perry; Groessl, Todd; Johnson, Kevin; Jia, Yong; Kasibhatla, Shailaja; Li, Chun; Isbell, John; Spraggon, Glen; Bender, Steven; Michellys, Pierre-Yves 分享 收藏
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Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody Malito, Enrico; Biancucci, Marco; Faleri, Agnese; Ferlenghi, Ilaria; Scarselli, Maria; Maruggi, Giulietta; Lo Surdo, Paola; Veggi, Daniele; Liguori, Alessia; Santini, Laura; Bertoldi, Isabella; Petracca, Roberto; Marchi, Sara; Romagnoli, Giacomo; Cartocci, Elena; Vercellino, Irene; Savino, Silvana; Spraggon, Glen; Norais, Nathalie; Pizza, Mariagrazia; Rappuoli, Rino; Masignani, Vega; Bottomley, Matthew James 分享 收藏
Mining the bacterial unknown proteome: identification and characterization of a novel family of highly conserved protective antigens in Staphylococcus aureus Schluepen, Christina; Malito, Enrico; Marongiu, Ambra; Schirle, Markus; McWhinnie, Elisabeth; Lo Surdo, Paola; Biancucci, Marco; Falugi, Fabiana; Nardi-Dei, Vincenzo; Marchi, Sara; Fontana, Maria Rita; Lombardi, Benedetta; De Falco, Maria Grazia; Rinaudo, C. Daniela; Spraggon, Glen; Nissum, Mikkel; Bagnoli, Fabio; Grandi, Guido; Bottomley, Matthew J.; Liberatori, Sabrina 分享 收藏
Structural and functional characterization of the Staphylococcus aureus virulence factor and vaccine candidate FhuD2 Mariotti, Paolo; Malito, Enrico; Biancucci, Marco; Lo Surdo, Paola; Mishra, Ravi P. N.; Nardi-Dei, Vincenzo; Savino, Silvana; Nissum, Mikkel; Spraggon, Glen; Grandi, Guido; Bagnli, Fabio; Bttomley, Matthew J. 分享 收藏
FdeC, a Novel Broadly Conserved Escherichia coli Adhesin Eliciting Protection against Urinary Tract Infections Nesta, Barbara; Spraggon, Glen; Alteri, Christopher; Moriel, Danilo Gomes; Rosini, Roberto; Veggi, Daniele; Smith, Sara; Bertoldi, Isabella; Pastorello, Ilaria; Ferlenghi, Ilaria; Fontana, Maria Rita; Frankel, Gad; Mobley, Harry L. T.; Rappuoli, Rino; Pizza, Mariagrazia; Serino, Laura; Soriani, Marco 分享 收藏
Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197 Malito, Enrico; Bursulaya, Badry; Chen, Connie; Lo Surdo, Paola; Picchianti, Monica; Balducci, Enrico; Biancucci, Marco; Brock, Ansgar; Berti, Francesco; Bottomley, Matthew James; Nissum, Mikkel; Costantino, Paolo; Rappuoli, Rino; Spraggon, Glen 分享 收藏
Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain Lee, Christian C.; Jia, Yong; Li, Nanxin; Sun, Xiuying; Ng, Kenneth; Ambing, Eileen; Gao, Mu-Yun; Hua, Su; Chen, Connie; Kim, Sungjoon; Michellys, Pierre-Yves; Lesley, Scott A.; Harris, Jennifer L.; Spraggon, Glen 分享 收藏
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