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Building and Evolving a Chiral Control Strategy for Accelerated COVID Programs Allais, Christophe; Baldwin, Aaron F.; Clarke, Hugh J.; Connor, Christina G.; Coutant, Michael; Duong, Cindy; Herr, Michael; James, Chintelle; Kalinowski, Maciej; Lee, Johnny W.; Liu, Yizhou; Piper, Jared L.; Ragan, John A.; Salisbury, John J.; Weekly, R. Matthew; Yu, Shu; Zhang, Mengtan 分享 收藏
Pinnick Oxidation on Scale: Process Development of a BDK Inhibitor Arcari, Joel T.; Buckley, Catherine; Buzon, Leanne M.; Dan, Yongbo; Houck, Timothy; Jin, Zuxi; Li, Chao; Li, Peifang; Liu, Kai; Liu, Yiyang; Magano, Javier; Martinez-Alsina, Luis A.; Nguyen, Bao; Pearson, Robert; Piper, Jared L.; Ragan, John A.; Reese, Matthew R.; Tian, Wanli; Van Haitsma, Jared; Vetelino, Michael G.; Zhang, Yuan 分享 收藏
Synthesis of Nirmatrelvir: Development of a Scalable Cobalt-Catalyzed Cyclopropanation for Manufacture of the Bicyclic [3.1.0]Proline-Building Block Algera, Russell F.; Allais, Christophe; Baldwin, Aaron F.; Busch, Torsten; Colombo, Federica; Colombo, Matteo; Depretz, Christelle; Dumond, Yves Rene; Faria Quintero, Andres R.; Heredia, Maria; Jung, Jorg; Lall, Amrita; Lee, Taegyo; Liu, Yizhou; Mandelli, Stefano; Mantel, Marvin; Morris, Ronald; Mustakis, Jason; Nguyen, Bao; Pearson, Robert; Piper, Jared L.; Ragan, John A.; Ruffin, Brigitte; Talicska, Courtney; Tcyrulnikov, Sergei; Uyeda, Christopher; Weekly, R. Matthew; Zeng, Ming 分享 收藏
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment Algera, Russell F.; Allais, Christophe; Baldwin, Aaron F.; Becirovic, Husein; Bowles, Paul; Brown, Adam R.; Buske, Jamie M.; Clarke, Hugh J.; Do, Nga M.; Doyle, Kevin; Fifer, Jonathan; Gray, Kaitlyn; Happe, Alan; Hardink, Mark; Hubbell, Aran K.; James, Chintelle; Khadamkar, Hrushikesh P.; Magano, Javier; McInturff, Emma L.; Mustakis, Jason; Ozbuyukkaya, Gizem; Piper, Jared L.; Place, David W.; Ragan, John A.; Rauschenberger, Blake; Reyes, Giselle; Shehadeh, Rawan; Stanchina, Corey; Stanley, Michael; Weekly, R. Matthew; Weinstein, Ethan; Weisenburger, Gerald A.; Wood, Ethan; Yayla, Hatice G.; Yu, Shu 分享 收藏
Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment Algera, Russell F.; Allais, Christophe; Becirovic, Husein; Brown, Adam R.; Chen, Bo; Clarke, Hugh J.; Concannon, Paul E.; Du, Yansheng; Georgian, William; Lee, Johnny W.; Lee, Taegyo; Magano, Javier; Mandry, Carlos Perez; Mehta, Ruchi; Mull, Eric; Pearson, Robert; Peng, Zhihui; Piper, Jared L.; Ragan, John A.; Reyes, Giselle; Shen, Haibo; Ward, Daniel W.; Weekly, R. Matthew; Weisenburger, Gerald A.; Xu, Pengcheng; Yayla, Hatice G.; Zhang, Mengtan 分享 收藏
Synthesis of Nirmatrelvir: Design and Optimization of an Efficient Telescoped Amidation-Dehydration Sequence Algera, Russell F.; Baldwin, Aaron F.; Bowles, Paul; Clarke, Hugh J.; Connor, Christina G.; Cordi, Eric M.; Do, Nga M.; Nicholson, Lindsay D.; Georgian, William; Happe, Alan; Herman, Madeline I.; Hilou, Elaa; James, Chintelle; Johnson, Amber M.; Kalinowski, Maciej; Kulkarni, Samir A.; Launer-Felty, Katherine D.; Lee, Johnny W.; Lee, Taegyo; Lopez, Jorge; Mcinturff, Emma L.; Piper, Jared L.; Place, David W.; Ragan, John A.; Rauschenberger, Blake; Ryder, Katherine; Stanley, Michael; Weisenburger, Gerald A.; Weekly, R. Matthew; Allais, Christophe 分享 收藏
Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C-O Coupling, Part II: Pilot Plant Scale Manufacture Abercrombie, Cameron; Ashcroft, Christopher P.; Badland, Matthew; Baldwin, Aaron; Baldwin, Livia T.; Brisley, Sarah; Callar, Wayne; Daddario, Pedro; Hilou, Elaa; James, Chintelle; Li, Ruizhi; Liu, Yiyang; Monfette, Sebastien; Piper, Jared L.; Reyes, Giselle; Risley, Hud; Salingue, Fabrice H.; Saunyama, Kudzai; Vetelino, Michael G. 分享 收藏
Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months Allais, Christophe; Connor, Christina G.; Do, Nga M.; Kulkarni, Samir; Lee, Johnny W.; Lee, Taegyo; McInturff, Emma; Piper, Jared; Place, Dave W.; Ragan, John A.; Weekly, R. Matt 分享 收藏
Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture Baldwin, Aaron; Cabral, Shawn; Jones, Kris N.; Kohrt, Jeffrey T.; Limberakis, Chris; Liu, Yiyang; Magano, Javier; Monfette, Sebastien; Nematalla, Asaad; Ovaska, Sami; Piotrowski, David W.; Piper, Jared L.; Raggon, Jeffrey W.; Thuma, Benjamin A.; Wei, Liuqing 分享 收藏
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Brønsted acid-enhanced direct hydrogen atom transfer photocatalysis for selective functionalization of unactivated C(sp3)-H bonds 布朗斯台德酸增强的直接氢原子转移光催化用于未活化的C(sp3)-H键的选择性官能化 Cao, Hui; Kong, Degong; Yang, Li-Cheng; Chanmungkalakul, Supphachok; Liu, Tao; Piper, Jared L.; Peng, Zhihui; Gao, Linlin; Liu, Xiaogang; Hong, Xin; Wu, Jie 分享 收藏
Difluoromethylation of Unactivated Alkenes Using Freon-22 through Tertiary Amine-Borane-Triggered Halogen Atom Transfer Zhang, Zhi-Qi; Sang, Yue-Qian; Wang, Cheng-Qiang; Dai, Peng; Xue, Xiao-Song; Piper, Jared L.; Peng, Zhi-Hui; Ma, Jun-An; Zhang, Fa-Guang; Wu, Jie 分享 收藏
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A radical chlorodifluoromethylation protocol for late-stage difluoromethylation and its application to an oncology candidate Meng, Depei; Li, Lingchun; Brown, Adam; Desrosiers, Jean-Nicolas; Duan, Shengquan; Hayward, Cheryl M.; He, Zhengbiao; Hu, Jinbo; Makowski, Teresa; Maloney, Mark; Monfette, Sebastien; Perfect, Hahdi; Piper, Jared L.; Zhou, Min; Widlicka, Daniel W. 分享 收藏
Development of a Scalable Synthesis of Mevidalen (LY3154207), an Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor Richardson, Jeffery; Cole, Kevin P.; DeBaillie, Amy C.; Hao, Junliang; Piper, Jared; Houghton, Peter; Rizzo, John; Jia, Mo; Liu, Peng; Huang, Ping; Kadlecikova, Katarina; Garcia, Conchita F.; Richards, Daniel S. 分享 收藏
The PMI Predictor app to enable green-by-design chemical synthesis Borovika, Alina; Albrecht, Jacob; Li, Jun; Wells, Andrew S.; Briddell, Christiana; Dillon, Barry R.; Diorazio, Louis J.; Gage, James R.; Gallou, Fabrice; Koenig, Stefan G.; Kopach, Michael E.; Leahy, David K.; Martinez, Isamir; Olbrich, Martin; Piper, Jared L.; Roschangar, Frank; Sherer, Edward C.; Eastgate, Martin D. 分享 收藏
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470) Hamdouchi, Chafiq; Kahl, Steven D.; Lewis, Anjana Patel; Cardona, Guemalli R.; Zink, Richard W.; Chen, Keyue; Eessalu, Thomas E.; Ficorilli, James V.; Marcelo, Marialuisa C.; Otto, Keith A.; Wilbur, Kelly L.; Lineswala, Jayana P.; Piper, Jared L.; Coffey, D. Scott; Sweetana, Stephanie A.; Haas, Joseph V.; Brooks, Dawn A.; Pratt, Edward J.; Belin, Ruth M.; Deeg, Mark A.; Ma, Xiaosu; Cannady, Ellen A.; Johnson, Jason T.; Yumibe, Nathan P.; Chen, Qi; Maiti, Pranab; Montrose-Rafizadeh, Chahrzad; Chen, Yanyun; Miller, Anne Reifel 分享 收藏
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