未登录Potent combination benefit of the AKT inhibitor capivasertib and the BCL-2 inhibitor venetoclax in diffuse large B cell lymphoma
Willis, Brandon S.; Mongeon, Kevin; Dry, Hannah; Neveras, India L.; Bryan, Nadezda; Pandya, Meghana; Roderick-Richardson, Justine; Xu, Wendan; Yang, Li; Rosen, Alan; Reimer, Corinne; Tuskova, Liliana; Klener, Pavel; Mettetal, Jerome T.; Lenz, Georg; Barry, Simon T. .png)
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收藏Discovery of potent and selective pan-TEAD autopalmitoylation inhibitors for the treatment of Hippo-pathway altered cancersGordon, Jacob A.; Dubauskaite, Jolanta; DuPont, Michelle; Guan, Nin; Holdgate, Geoff; Mlynarski, Scott; Umbreit, Neil; Sanchez, Danielle; Srivastava, Abhishek; Suski, Janek; Su, Nancy; Richards, Ryan; Cosulich, Sabina; Reimer, Corinne; Brownell, James 分享 收藏 分享 收藏 A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse ModelsWhite, Michael J.; Cheatham, Letitia; Wen, Shenghua; Scarfe, Graeme; Cidado, Justin; Reimer, Corinne; Hariparsad, Niresh; Jones, Rhys D. O.; Drew, Lisa; McGinnity, Dermot F.; Vasalou, Christina 分享 收藏 Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapyPatterson, Claire M.; Balachander, Srividya B.; Grant, Iain; Pop-Damkov, Petar; Kelly, Brian; McCoull, William; Parker, Jeremy; Giannis, Michael; Hill, Kathryn J.; Gibbons, Francis D.; Hennessy, Edward J.; Kemmitt, Paul; Harmer, Alexander R.; Gales, Sonya; Purbrick, Stuart; Redmond, Sean; Skinner, Matthew; Graham, Lorraine; Secrist, J. Paul; Schuller, Alwin G.; Wen, Shenghua; Adam, Ammar; Reimer, Corinne; Cidado, Justin; Wild, Martin; Gangl, Eric; Fawell, Stephen E.; Saeh, Jamal; Davies, Barry R.; Owen, David J.; Ashford, Marianne B. 分享 收藏 Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumorsBanks, Erica; Grondine, Michael; Bhavsar, Deepa; Barry, Evan; Kettle, Jason G.; Reddy, Venkatesh Pilla; Brown, Crystal; Wang, Haiyun; Mettetal, Jerome T.; Collins, Teresa; Adeyemi, Oladipupo; Overman, Ross; Lawson, Deborah; Harmer, Alexander R.; Reimer, Corinne; Drew, Lisa; Packer, Martin J.; Cosulich, Sabina; Jones, Rhys D. O.; Shao, Wenlin; Wilson, David; Guichard, Sylvie; Fawell, Stephen; Anjum, Rana 分享 收藏 Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication StressYoung, Lucy A.; O'Connor, Lenka Oplustil; de Renty, Christelle; Veldman-Jones, Margaret H.; Dorval, Thierry; Wilson, Zena; Jones, David R.; Lawson, Deborah; Odedra, Rajesh; Maya-Mendoza, Apolinar; Reimer, Corinne; Bartek, Jiri; Lau, Alan; O'Connor, Mark J. 分享 收藏 Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast CancerWang, Zebin; Grosskurth, Shaun E.; Cheung, Tony; Petteruti, Philip; Zhang, Jingwen; Wang, Xin; Wang, Wenxian; Gharahdaghi, Farzin; Wu, Jiaquan; Su, Nancy; Howard, Ryan T.; Mayo, Michele; Widzowski, Dan; Scott, David A.; Johannes, Jeffrey W.; Lamb, Michelle L.; Lawson, Deborah; Dry, Jonathan R.; Lyne, Paul D.; Tate, Edward W.; Zinda, Michael; Mikule, Keith; Fawell, Stephen E.; Reimer, Corinne; Chen, Huawei 分享 收藏 分享 收藏 Inhibition of A2AR by AZD4635 induces anti-tumor immunity alone and in combination with anti-PD-L1 in preclinical modelsBorodovsky, Alexandra; Wang, Yanjun; Ye, Minwei; Shaw, Joseph C.; Sachsenmeier, Kris; Deng, Nanhua; Goodwin, Kelly; Clarke, James D.; Goodwin, Richard; Strittmatter, Nicole; Hay, Carl; Sah, Vasu; Deborah, Lawson; Reimer, Corinne; Congreve, Miles; Mason, Jonathan; Marshall, Fiona; Lyne, Paul; Woessner, Richard 分享 收藏 BRD4 facilitates replication stress-induced DNA damage responseZhang, Jingwen; Dulak, Austin M.; Hattersley, Maureen M.; Willis, Brandon S.; Nikkila, Jenni; Wang, Anderson; Lau, Alan; Reimer, Corinne; Zinda, Michael; Fawell, Stephen E.; Mills, Gordon B.; Chen, Huawei 分享 收藏 Inhibition of STAT3 by antisense oligonucleotide treatment decreases the immune suppressive tumor microenvironment in syngeneic and GEM tumor modelsWoessner, Rich; Sah, Vasu; McCoon, Patricia; Grosskurth, Shaun; Deng, Nanhua; DuPont, Rachel; Lawson, Deborah; Pablo, Lourdes; Reimer, Corinne; De Velasco, Marco A.; Uemura, Hirotsugu; Candido, Juliana; Lyne, Paul 分享 收藏 Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppressionBorodovsky, Alexandra; Wang, Yanjun; Ye, Minwei; Shaw, Joseph C.; Sachsenmeier, Kris F.; Deng, Nanhua; DelSignore, Kelly J.; Fretland, Adrian J.; Clarke, James D.; Goodwin, Richard J.; Strittmatter, Nicole; Hay, Carl; Sah, Vasu R.; Lawson, Deborah; Reimer, Corinne; Congreve, Miles; Mason, Jonathan S.; Marshall, Fiona H.; Lyne, Paul; Woessner, Richard 分享 收藏 Identify BRD4 as a facilitator of replication stress response signalingZhang, Jingwen; Willis, Brandon; Hattersley, Maureen; Lau, Alan; Reimer, Corinne; Zinda, Michael; Fawell, Stephen; Mills, Gordon; Dulak, Austin; Chen, Huawei 分享 收藏 AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic MalignanciesRhyasen, Garrett W.; Hattersley, Maureen M.; Yao, Yi; Dulak, Austin; Wang, Wenxian; Petteruti, Philip; Dale, Ian L.; Boiko, Scott; Cheung, Tony; Zhang, Jingwen; Wen, Shenghua; Castriotta, Lillian; Lawson, Deborah; Collins, Michael; Bao, Larry; Ahdesmaki, Miika J.; Walker, Graeme; O'Connor, Greg; Yeh, Tammie C.; Rabow, Alfred A.; Dry, Jonathan R.; Reimer, Corinne; Lyne, Paul; Mills, Gordon B.; Fawell, Stephen E.; Waring, Michael J.; Zinda, Michael; Clark, Edwin; Chen, Huawei 分享 收藏 Therapeutic activity of bivalent BRD4 inhibitor AZD5153 in hematological cancersChen, Huawei Ray; Hattersley, Maureen; Rhyasen, Garrett; Dulak, Austin; Wang, Wendy; Petteruti, Phil; Dale, Ian; Cheung, Tony; Wen, Shenghua; Castriotta, Lilian; Lawson, Deborah; Collins, Mike; Ahdesmaki, Miika; Walker, Graeme; Rabow, Al; Dry, Jonathan; Reimer, Corinne; Lyne, Paul; Fawell, Steve; Waring, Mike; Zinda, Mike; Clark, Ed; Clark, Ed 分享 收藏 Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivoAshton, Susan; Song, Young Ho; Nolan, Jim; Cadogan, Elaine; Murray, Jim; Odedra, Rajesh; Foster, John; Hall, Peter A.; Low, Susan; Taylor, Paula; Ellston, Rebecca; Polanska, Urszula M.; Wilson, Joanne; Howes, Colin; Smith, Aaron; Goodwin, Richard J. A.; Swales, John G.; Strittmatter, Nicole; Takats, Zoltan; Nilsson, Anna; Andren, Per; Trueman, Dawn; Walker, Mike; Reimer, Corinne L.; Troiano, Greg; Parsons, Donald; De Witt, David; Ashford, Marianne; Hrkach, Jeff; Zale, Stephen; Jewsbury, Philip J.; Barry, Simon T. 分享 收藏 AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancerHong, David; Kurzrock, Razelle; Kim, Youngsoo; Woessner, Richard; Younes, Anas; Nemunaitis, John; Fowler, Nathan; Zhou, Tianyuan; Schmidt, Joanna; Jo, Minji; Lee, Samantha J.; Yamashita, Mason; Hughes, Steven G.; Fayad, Luis; Piha-Paul, Sarina; Nadella, Murali V. P.; Mohseni, Morvarid; Lawson, Deborah; Reimer, Corinne; Blakey, David C.; Xiao, Xiaokun; Hsu, Jeff; Revenko, Alexey; Monia, Brett P.; MacLeod, A. Robert 分享 收藏 Pharmacodynamic response and anti-tumor activity of the MET inhibitor AZD6094 in papillary renal cell carcinoma patient derived xenograft modelsSchuller, Alwin; Barry, Evan; Jones, Rhys; Frigault, Melanie; Beran, Garry; Henry, Ryan; Linsenmayer, David; Hattersley, Maureen; Smith, Aaron; Wilson, Joanne; Adam, Ammar; Zinda, Michael; Reimer, Corinne; Fawell, Stephen; Clark, Edwin; D'Cruz, Celina 分享 收藏 Changing the paradigm for treating drug resistance in NSCLC: Novel combinations of AZD6094, a selective MET inhibitor, and an irreversible, selective (EGFRm/T790M) EGFRTKI, AZD9291D'Cruz, Celina; Barry, Evan; Henry, Ryan; Castriotta, Lillian; Schuller, Alwin; Beran, Garry; Ashton, Susan; Eberlein, Cath; Reimer, Corinne; Frigault, Melanie; Zinda, Michael; Cross, Darren; Fawell, Stephen 分享 收藏 
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