未登录 BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate Cherney, Robert J.; Anjanappa, Prakash; Selvakumar, Kumaravel; Batt, Douglas G.; Brown, Gregory D.; Rose, Anne, V; Vuppugalla, Ragini; Chen, Jing; Pang, Jian; Xu, Songmei; Yarde, Melissa; Tebben, Andrew J.; Paidi, Venkatram Reddy; Cvijic, Mary Ellen; Mathur, Arvind; Barrish, Joel C.; Mandlekar, Sandhya; Zhao, Qihong; Carter, Percy H. 分享 收藏
Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2 Yang, Michael G.; Xiao, Zili; Zhao, Rulin; Tebben, Andrew J.; Wang, Bei; Cherney, Robert J.; Batt, Douglas G.; Brown, Gregory D.; Cvijic, Mary Ellen; Duncia, John, V; Gallela, Michael A.; Gardner, Daniel S.; Khandelwal, Purnima; Malley, Mary F.; Pang, Jian; Rose, Anne, V; Santella, Joseph B., III; Sarjeant, Amy A.; Xu, Songmei; Mathur, Arvind; Mandlekar, Sandhya; Vuppugalla, Ragini; Zhao, Qihong; Carter, Percy H. 分享 收藏
Synthesis of 1-(tert-Butyl) 4-Methyl (1R,2S,4R)-2-Methylcyclohexane-1,4-dicarboxylate from Hagemann's tert-Butyl Ester for an Improved Synthesis of BMS-986251 Cornelius, Lyndon A. M.; Li, Jianqing; Smith, Daniel; Krishnananthan, Subramaniam; Yip, Shiuhang; Wu, Dauh-Rurng; Pawluczyk, Joseph; Aulakh, Darpandeep; Sarjeant, Amy A.; Kempson, James; Tino, Joseph A.; Mathur, Arvind; Dhar, T. G. Murali; Cherney, Robert J. 分享 收藏
Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist Cherney, Robert J.; Cornelius, Lyndon A. M.; Srivastava, Anurag; Weigelt, Carolyn A.; Marcoux, David; Duan, James J-W; Shi, Qing; Batt, Douglas G.; Liu, Qingjie; Yip, Shiuhang; Wu, Dauh-Rurng; Ruzanov, Max; Sack, John; Khan, Javed; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Mathur, Arvind; Li, Sha; Shuster, David; Khandelwal, Purnima; Borowski, Virna; Xie, Jenny; Obermeier, Mary; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Tino, Joseph A.; Macor, John E.; Salter-Cid, Luisa; Denton, Rex; Zhao, Qihong; Carter, Percy H.; Dhar, T. G. Murali 分享 收藏
Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy Marcoux, David; Duan, James J. -W.; Shi, Qing; Cherney, Robert J.; Srivastava, Anurag S.; Cornelius, Lyndon; Batt, Douglas G.; Liu, Qingjie; Beaudoin-Bertrand, Myra; Weigelt, Carolyn A.; Khandelwal, Purnima; Vishwakrishnan, Sureshbabu; Selvakumar, Kumaravel; Karmakar, Ananta; Gupta, Arun Kumar; Basha, Mushkin; Ramlingam, Sridharan; Manjunath, Naveen; Vanteru, Sridhar; Karmakar, Sukhen; Maddala, Nageswara; Vetrichelvan, Muthalagu; Gupta, Anuradha; Rainpulla, Richard A.; Mathur, Arvind; Yip, Shiuhang; Li, Peng; Wu, Dauh-Rurng; Khan, Javed; Ruzanov, Max; Sack, John S.; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Li, Sha; Shuster, David J.; Borowski, Virna; Xie, Jenny H.; McIntyre, Kim W.; Obermeier, Mary T.; Fura, Aberra; Stefanski, Kevin; Cornelius, Georgia; Hynes, John, Jr.; Tino, Joseph A.; Macor, John E.; Salter-Cid, Luisa; Denton, Rex; Zhao, Qihong; Carter, Percy H.; Dhare, T. G. Murali 分享 收藏
A Radical Approach to Anionic Chemistry: Synthesis of Ketones, Alcohols, and Amines Ni, Shengyang; Padial, Natalia M.; Kingston, Cian; Vantourout, Julien C.; Schmitt, Daniel C.; Edwards, Jacob T.; Kruszyk, Monika M.; Merchant, Rohan R.; Mykhailiuk, Pavel K.; Sanchez, Brittany B.; Yang, Shouliang; Perry, Matthew A.; Gallego, Gary M.; Mousseau, James J.; Collins, Michael R.; Cherney, Robert J.; Lebed, Pavlo S.; Chen, Jason S.; Qin, Tian; Baran, Phil S. 分享 收藏
Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672 Yang, Michael G.; Xiao, Zili; Cherney, Robert J.; Tebben, Andrew J.; Batt, Douglas G.; Brown, Gregory D.; Chen, Jing; Cvijic, Mary Ellen; Dabros, Marta; Duncia, John V.; Galena, Michael; Gardner, Daniel S.; Khandelwal, Purnima; Ko, Soo S.; Malley, Mary F.; Mo, Ruowei; Pang, Jian; Rose, Anne V.; Santella, Joseph B., III; Shi, Hong; Srivastava, Anurag; Traeger, Sarah C.; Wang, Bei; Xu, Songmei; Zhao, Rulin; Barrish, Joel C.; Mandlekar, Sandhya; Zhao, Qihong; Carter, Percy H. 分享 收藏
Preclinical antitumor activity of a CC chemokine receptor (CCR) 2/5 dual antagonist as monotherapy and in combination with immune checkpoint blockade Zhao, Qihong; Murtaza, Anwar; Bata, Adam; Sun, Wendy; Ho, Ching-Ping; Vuppugalla, Ragini; Cherney, Robert; Stefanski, Kevin; Cao, Z. Alexander; Sama, Ashwin; Yang, Arvin; Struthers, Mary; Sanjuan, Miguel; Hunt, John T.; Carter, Percy; Salter-Cid, Luisa 分享 收藏
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (P13Kδ) Inhibitor for the Treatment of Immunological Disorders Liu, Qingjie; Shi, Qing; Marcoux, David; Batt, Douglas G.; Cornelius, Lyndon; Qin, Lan-Ying; Ruan, Zheming; Neels, James; Beaudoin-Bertrand, Myra; Srivastava, Anurag S.; Li, Ling; Cherney, Robert J.; Gong, Hua; Watterson, Scott H.; Weigelt, Carolyn; Gillooly, Kathleen M.; McIntyre, Kim W.; Xie, Jenny H.; Obermeier, Mary T.; Fura, Aberra; Sleczka, Bogdan; Stefanski, Kevin; Fancher, R. M.; Padmanabhan, Shweta; Thatipamula, R. P.; Kundu, Ipsit; Rajareddy, Kallem; Smith, Rodney; Herman, James K.; Xing, Dezhi; Fan, Jingsong; Levesque, Paul C.; Ruan, Qian; Pitt, Sidney; Zhang, Rosemary; Pedicord, Donna; Pan, Jie; Yarde, Melissa; Lu, Hao; Lippy, Jonathan; Goldstine, Christine; Skala, Stacey; Rampulla, Richard A.; Mathur, Arvind; Gupta, Anuradha; Arunachalam, Pirama Nayagam; Sack, John S.; Muckelbauer, Jodi K.; Cvijic, Mary Ellen; Salter-Cid, Luisa M.; Bhide, Rajeev S.; Poss, Michael A.; Hynes, John; Carter, Percy H.; Macor, John E.; Ruepp, Stefan; Schieven, Gary L.; Tino, Joseph A. 分享 收藏
Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design Xiao, Hai-Yun; Watterson, Scott H.; Langevine, Charles M.; Srivastava, Anurag S.; Ko, Soo S.; Zhang, Yanlei; Cherney, Robert J.; Guo, Wei-Wei; Gilmore, John L.; II, James E. Sheppeck; Wu, Dauh-Rurng; Li, Peng; Ramasamy, Duraisamy; Arunachalam, Piramanayagam; Mathur, Arvind; Taylor, Tracy L.; Shuster, David J.; McIntyre, Kim W.; Shen, Ding-Ren; Yarde, Melissa; Cvijic, Mary Ellen; Marino, Anthony M.; Balimane, Praveen V.; Yang, Zheng; Banas, Dana M.; Cornelius, Georgia; D'Arienzo, Celia J.; Warrack, Bethanne M.; Lehman-McKeeman, Lois; Salter-Cid, Luisa M.; Xie, Jenny; Barrish, Joel C.; Carter, Percy H.; Dyckman, Alaric J.; Dhar, T. G. Murali 分享 收藏
Discovery of a Potent and Orally Bioavailable Dual Antagonist of CC Chemokine Receptors 2 and 5 Carter, Percy H.; Brown, Gregory D.; Cherney, Robert J.; Batt, Douglas G.; Chen, Jing; Clark, Cheryl M.; Cvijic, Mary Ellen; Duncia, John V.; Ko, Soo S.; Mandlekar, Sandhya; Mo, Ruowei; Nelson, David J.; Pang, Jian; Rose, Anne V.; Santella, Joseph B., III; Tebben, Andrew J.; Traeger, Sarah C.; Xu, Songmei; Zhao, Qihong; Barrish, Joel C. 分享 收藏
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Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists Cherney, Robert J.; Mo, Ruowei; Meyer, Dayton T.; Nelson, David J.; Lo, Yvonne C.; Yang, Gengjie; Scherle, Peggy A.; Mandlekar, Sandhya; Wasserman, Zelda R.; Jezak, Heather; Solomon, Kimberly A.; Tebben, Andrew J.; Carter, Percy H.; Decicco, Carl P. 分享 收藏
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Sultam hydroxamates as novel matrix metalloproteinase inhibitors Cherney, RJ; Mo, RW; Meyer, DT; Hardman, KD; Liu, RQ; Covington, MB; Qian, MX; Wasserman, ZR; Christ, DD; Trzaskos, JM; Newton, RC; Decicco, CP 分享 收藏
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-α converting enzyme inhibitors Cherney, RJ; Duan, JJW; Voss, ME; Chen, LH; Wang, L; Meyer, DT; Wasserman, ZR; Hardman, KD; Liu, RQ; Covington, MB; Qian, MX; Mandlekar, S; Christ, DD; Trzaskos, JM; Newton, RC; Magolda, RL; Wexler, RR; Decicco, CP 分享 收藏
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Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor α release in vitro and in vivo Xue, CB; Voss, ME; Nelson, DJ; Duan, JJW; Cherney, RJ; Jacobson, IC; He, XH; Roderick, J; Chen, LH; Corbett, RL; Wang, L; Meyer, DT; Kennedy, K; DeGrado, WF; Hardman, KD; Teleha, CA; Jaffee, BD; Liu, RQ; Copeland, RA; Covington, MB; Christ, DD; Trzaskos, JM; Newton, RC; Magolda, RL; Wexler, RR; Decicco, CP 分享 收藏
Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-α production Xue, CB; He, XH; Roderick, J; DeGrado, WF; Cherney, RJ; Hardman, KD; Nelson, DJ; Copeland, RA; Jaffee, BD; Decicco, CP 分享 收藏
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