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Tracy L. Diamond

Merck & Co., Inc.
H指数:15
被引数:2,124

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Switching to Daily Doravirine/Islatravir (100/0.25 mg) Maintains Viral Suppression Through Week 48 Despite Baseline Non-Nucleoside Reverse Transcriptase Inhibitor Resistance–Associated Mutations or M184I/V in Proviral DNA

尽管存在基线非核苷类逆转录酶抑制剂耐药相关突变或原病毒DNA中的M184I/V,每日多拉维林/伊拉曲韦(100/0.25 mg)切换疗法在48周内维持病毒抑制

2026-05-290
OA
Fixed-dose daily doravirine (100 mg) with islatravir (0·25 mg) versus bictegravir, emtricitabine, and tenofovir alafenamide for initial HIV-1 therapy: 48-week results of a phase 3, randomised, controlled, double-blind, non-inferiority trial

固定剂量每日多拉维林(100 mg)联合伊拉曲拉韦(0·25 mg)与比克替拉韦、恩曲他滨和替诺福韦艾拉酚胺用于初始HIV-1治疗:一项III期、随机、对照、双盲、非劣效性试验的48周结果

2026-02-250
PRE
Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on bictegravir, emtricitabine, and tenofovir alafenamide: 48-week results of a phase 3, multicentre, randomised, controlled, double-blind, non-inferiority trial

在病毒学抑制的成人中,每天一次使用固定剂量的多拉韦林 (100 mg) 和islatravir (0·25 mg),HIV-1使用bicegravir,恩曲他滨和替诺福韦alafenamide: 3期,多中心,随机,对照的48周结果,双盲,非劣效性试验

2026-02-050
PRE
Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on oral antiretroviral therapy: 48-week results of a phase 3, multicentre, randomised, open-label, non-inferiority trial

在接受口服抗逆转录病毒治疗的HIV-1的病毒学抑制成人中,每天一次改用固定剂量的doravirine (100 mg) 和islatravir (0·25 mg): 3期,多中心,随机,开放标签,非劣效性试验的48周结果

2026-02-050
PRE
Weekly Oral Prophylaxis With MK-8527 Protects Rhesus Macaques From Intrarectal Challenge With Simian-Human Immunodeficiency Virus

每周口服MK-8527预防可保护恒河猴免受经直肠感染人猿免疫缺陷病毒的挑战

2025-12-010
OAAI
Discovery of [11C]MK-8056: A Selective PET Imaging Agent for the Study of mGluR2 Negative Allosteric Modulators
2023-06-132
OA
Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1
2023-02-2211
PRE
A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells
2022-08-3118
PRE
Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors
2017-11-2137
OAAI
Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group
2016-05-1122
OAAI