Vladimir Tolmachev - Publications, H-index & Citations

Vladimir Tolmachev

uppsala university

63H指数

607论文数

1.5W被引数

收录论文 176

发表时间

Experimental radiotherapy with the gastrin-releasing peptide receptor (GRPR) antagonist [¹⁷⁷Lu]Lu-AU-SAR-M1 in a prostate cancer murine model using reduced-frequency dosing 在前列腺癌小鼠模型中使用减少频率给药的实验性放射疗法，采用胃泌素释放肽受体（GRPR）拮抗剂 [¹⁷⁷Lu]Lu-AU-SAR-M1

BIOMEDICINE & PHARMACOTHERAPY

IF7.5

2026-09-05

OAAI

Karim Obeid; Mark Konijnenberg; Ekaterina Bezverkhniaia; Theodosia Maina; Berthold A. Nock; Vladimir Tolmachev; Panagiotis Kanellopoulos; Anna Orlova

Imaging of ROR1 expression in tumors using radiolabeled affibody molecules 使用放射性标记的亲和体分子对肿瘤中ROR1表达进行成像

European Journal of Nuclear Medicine and Molecular Imaging

IF7.6

2026-08-01

OAAI

Cornelia Westerberg; Tianqi Xu; Maria Marth; Moeen Ud-Din; Russol Abushaia; Tilde Hagelin; Stefan Ståhl; Anna Orlova; Vladimir Tolmachev; John Löfblom; Anzhelika Vorobyeva

The Use of Glycine-Containing Peptide-Based Chelators for Labeling with 99mTc Improves the Imaging Properties of EpCAM-Targeting Designed Ankyrin Repeat Ec1 含甘氨酸肽基螯合剂在99mTc标记中的应用可改善靶向EpCAM的定制锚蛋白重复序列Ec1的成像特性

Molecular Pharmaceutics

IF4.5

2026-03-04

PREAI

Sergey Deyev; Anastasia Fominykh; Ruslan Varvashenya; Gleb Yanovich; Vitalina Bodenko; Evgenii Plotnikov; Mariia Tretyakova; Daria Eskova; Roman Zhelchan; Alexey Schulga; Elena Konovalova; Rustam Ziganshin; Anna Orlova; Mikhail Belousov; Vladimir Tolmachev; Mariia Larkina

Phase I Clinical Study with the GRPR-Antagonist [99mTc]Tc-DB8 for SPECT Imaging of Prostate Cancer: Does the Injected Peptide Mass Make a Difference?I期临床试验：使用GRPR-拮抗剂[⁹⁹ᵐTc]Tc-DB8进行前列腺癌SPECT成像——注射的肽质量是否会产生影响？

Pharmaceutics

IF5.5

2026-03-03

OAAI

Anna Orlova; Anastasia Rybina; Anna Medvedeva; Roman Zelchan; Olga Bragina; Liubov Tashireva; Maria Larkina; Ruslan Varvashenya; Nadejda Lushnikova; Panagiotis Kanellopoulos; Theodosia Maina; Berthold A. Nock; Vladimir Tolmachev; Vladimir Chernov

Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging 探索两种代谢稳定的GRPR靶向肽经Ga-68标记用于PET成像的诊疗潜力

EJNMMI Radiopharmacy and Chemistry

IF3.3

2026-02-17

OAAI

Karim Obeid; Ekaterina Bezverkhniaia; Vladimir Tolmachev; Anna Orlova; Panagiotis Kanellopoulos

Efficient 68Ga Labeling of a B7-H3-Targeting Affibody Molecule via Acyclic Tris(hydroxypyridinone) Chelator: Effects on Biodistribution in a Preclinical Model 通过无环三(羟吡啶酮)螯合剂高效标记B7-H3靶向Affibody分子：对预临床模型生物分布的影响

International Journal of Molecular Sciences

IF4.9

2026-02-10

OAAI

Vladimir Tolmachev; Amelinda Janice Herlina; Eleftherios Papalanis; Ekaterina A. Bezverkhniaia; Eva Ryer; Anna Orlova; Fredrik Y. Frejd; Maryam Oroujeni

The position of 99mTc-HYNIC and the molecular design of the DARPin G3 constructs influence the selection of an imaging tracer to detect expression in HER2-expressing tumors 99mTc-HYNIC的位置和DARPin G3构建体的分子设计影响用于检测HER2表达肿瘤的成像示踪剂的选择

Journal of Radioanalytical and Nuclear Chemistry

IF1.6

2026-02-01

PREAI

Larkina, Maria; Varvashenya, Ruslan; Prach, Anastasia; Plotnikov, Evgenii; Tretyakova, Maria; Eskova, Daria; Bodenko, Vitalina; Yanovich, Gleb; Schulga, Alexey; Konovalova, Elena; Ziganshin, Rustam; Belousov, Mikhail; Chernov, Vladimir; Tolmachev, Vladimir; Deyev, Sergey

Design of 3D spheroid models for drug-response studies of HER2-targeted radiopharmaceuticals 3D类器官模型的设计用于HER2靶向放射性药物的药物反应研究

Biomaterials Advances

IF6

2025-11-22

OAAI

Ivan V. Zelepukin; Lisa Fulterer; Ahmed D. Elshazli; Amelinda J. Herlina; Vladimir Tolmachev

Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution 改善GRPR靶向肽的放射诊疗应用：螯合剂修饰和α-甲基-L-色氨酸替换的启示

EJNMMI Radiopharmacy and Chemistry

IF3.3

2025-11-13

OAAI

Karim Obeid; Ekaterina Bezverkhniaia; Vladimir Tolmachev; Anna Orlova; Panagiotis Kanellopoulos

Head-to-head evaluation of new generation GRPR-targeting theranostics labelled with Lu-177 / Ga-68 头对头评估177Lu / 68Ga标记的新一代GRPR靶向诊疗药物

Nuclear Medicine and Biology

IF3

2025-11-10

PREAI

Panagiotis Kanellopoulos; Karim Obeid; Ekaterina Bezverkhniaia; Athanasios Bitzios; Vladimir Tolmachev; Anna Orlova

Comparative Preclinical Evaluation of the Tumor-Targeting Properties of Radioiodine and Technetium-Labeled Designed Ankyrin Repeat Proteins for Imaging of Epidermal Growth Factor Receptor Expression in Malignant Tumors 比较性临床前评价：放射性碘和锝标记的合成锚蛋白重复蛋白对恶性肿瘤表皮生长因子受体表达的肿瘤靶向成像特性

International Journal of Molecular Sciences 2025, Vol. 26, Page 10609

IF4.9

2025-10-31

OAAI

Mariia Larkina; Gleb Yanovich; Lutfi Aditya Hasnowo; Ruslan Varvashenya; Feruza Yuldasheva; Maria Tretyakova; Evgenii Plotnikov; Roman Zelchan; Alexey Schulga; Elena Konovalova; Rustam Ziganshin; Mikhail V. Belousov; Vladimir Tolmachev; Sergey M. Deyev

LINKER MODIFICATIONS IN RADIOLABELED RM26-BASED ANTAGONISTS TO GASTRIN-RELEASING PEPTIDE RECEPTOR (GRPR) IMPROVED TRACERS’ PHARMACOKINETICS 连接体修饰在放射性标记的RM26衍生的胃泌素释放肽受体（GRPR）拮抗剂中改善了示踪剂的药代动力学

European Journal of Pharmaceutical Sciences

IF4.7

2025-10-13

OAAI

Ekaterina Bezverkhniaia; Ayman Abouzayed; Panagiotis Kanellopoulos; Vladimir Tolmachev; Ulrika Rosenström; Anna Orlova

An anti-CEA affibody showing high-definition staining in human pancreatic cancer tissue sections and selective tumor targeting in vivo 一种抗-CEA affibody，在人体胰腺癌组织切片中显示出高分辨率染色，并在体内表现出选择性肿瘤靶向。

Translational Oncology

IF4.1

2025-08-28

PREAI

Johan Nilvebrant; Carlos Fernández Moro; Eleftherios Papalanis; Masih Ostad Novin; Haozhong Ding; Ruonan Li; Maryam Oroujeni; Arun Selvam; Béla Bozóky; Torbjörn Gräslund; Timea Szekerczes; Tatiana Sandalova; Hugh Salter; Adnane Achour; Vladimir Tolmachev; Mikael Björnstedt; Per-Åke Nygren

RM2 and DB15 analogues bearing [177Lu]Lu-DOTAGA via different linkers, as radiotherapeutics: a head-to-head comparative study RM2和DB15类似物通过不同连接臂连接[177Lu]Lu-DOTAGA，作为放射性治疗药物：一项头对头比较研究

EJNMMI Radiopharmacy and Chemistry

IF3.3

2025-07-31

OAAI

Panagiotis Kanellopoulos; Athanasios Bitzios; Ivan Zelepukin; Ekaterina Bezverkhniaia; Theodosia Maina; Berthold A. Nock; Vladimir Tolmachev; Anna Orlova

Single-Photon Emission Computer Tomography Imaging of Prostate-Specific Membrane Antigen (PSMA) Expression in Prostate Cancer Patients Using a Novel Peptide-Based Probe [99mTc]Tc-BQ0413 with Picomolar Affinity to PSMA: A Phase I/II Clinical Study 使用具有皮摩尔亲和力的新型肽基探针[⁹⁹mTc]Tc-BQ0413对前列腺癌患者中前列腺特异性膜抗原（PSMA）表达的单光子发射计算机断层成像研究：一项Ⅰ/Ⅱ期临床试验

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

IF3.7

2025-02-21

OAAI

Medvedeva, A; Chernov, V; Larkina, M; Rybina, A; Zelchan, R; Bragina, O; Varvashenya, R; Zebzeeva, O; Bezverkhniaia, E; Tolmachev, V; Orlova, A

Impact of Radiometal Chelates on In Vivo Visualization of Immune Checkpoint Protein Using Radiolabeled Affibody Molecules 放射性金属螯合物对使用放射性标记Affibody分子进行免疫检查点蛋白体内可视化的影响

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE

IF3.7

2025-02-19

OAAI

Tolmachev, V; Papalanis, E; Bezverkhniaia, EA; Rosly, AH; Vorobyeva, A; Orlova, A; Carlqvist, M; Frejd, FY; Oroujeni, M

Evaluation of ABD-Linked RM26 Conjugates for GRPR-Targeted Drug Delivery

ACS OMEGA

IF4.3

2024-08-15

OAAI

Nagy, Abel; Abouzayed, Ayman; Kanellopoulos, Panagiotis; Landmark, Fredrika; Bezverkhniaia, Ekaterina; Tolmachev, Vladimir; Orlova, Anna; Karlstrom, Amelie Eriksson

Evaluation of a novel 177Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile 评估具有脱敏ABD结构域和改善的生物分布特征的新型177lu-标记的治疗性亲和体分子

European Journal of Nuclear Medicine and Molecular Imaging

IF7.6

2024-07-15

OAAI

Liu, Yongsheng; Oroujeni, Maryam; Liao, Yunqi; Vorobyeva, Anzhelika; Bodenko, Vitalina; Orlova, Anna; Konijnenberg, Mark; Carlqvist, Matilda; Wahlberg, Elisabet; Loftenius, Annika; Frejd, Fredrik Y.; Tolmachev, Vladimir

Half-life extension via ABD-fusion leads to higher tumor uptake of an affibody-drug conjugate compared to PAS- and XTENylation.

JOURNAL OF CONTROLLED RELEASE

IF11.5

2024-06-01

OAAI

Zhang, Jie; Bodenko, Vitalina; Larkina, Maria; Bezverkhniaia, Ekaterina; Xu, Tianqi; Liao, Yunqi; Abouzayed, Ayman; Plotnikov, Evgenii; Tretyakova, Maria; Yuldasheva, Feruza; V. Belousov, Mikhail; Orlova, Anna; Tolmachev, Vladimir; Graslund, Torbjorn; Vorobyeva, Anzhelika

Affibody PET Imaging of HER2-Expressing Cancers as a Key to Guide HER2-Targeted Therapy

BIOMEDICINES

IF3.9

2024-05-14

OAAI

Eissler, Nina; Altena, Renske; Alhuseinalkhudhur, Ali; Bragina, Olga; Feldwisch, Joachim; Wuerth, Guido; Loftenius, Annika; Brun, Nikolai; Axelsson, Rimma; Tolmachev, Vladimir; Sorensen, Jens; Frejd, Fredrik Y.

研究方向