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收藏Enabling the First Scale-Up of the Selective HER2 Inhibitor BI-4142实现选择性HER2抑制剂BI-4142的首个规模化生产
Chong, Eugene; Li, Ruoshi; Dong, Weitong; Chevliakov, Maxim; Tampone, Thomas G.; Zhang, Yongda; Qu, Bo; Haddad, Nizar; Lorenz, Jon C.; Sarvestani, Max; Omar, Thuraya; Li, Huayu; Gao, Joe J.; Gao, Donghong A.; Pennino, Scott; Wu, Ling; Spinelli, Earl; Yao, Steven; Lee, Heewon; Buono, Frederic; Song, Jinhua J.; Wilding, Birgit 分享 收藏 分享 收藏 分享 收藏 Building a Quaternary Stereogenic Center on Dihydroazaindole Carboxylic Acid through Scalable Process DevelopmentLee, Jaehee; Li, Guisheng; Zeng, Xingzhong; Haddad, Nizar; Abeyta, Vincent; Pennino, Scott; Wu, Lifen; Gao, Joe; Jiang, Qi; Lorenz, Jon C.; Wang, Jun; Wu, Jiang-Ping; Brazzillo, Jason; Sarvestani, Max; Wang, Xiao-Jun; El-Awa, Ahmad; Leung, Joyce C.; Qu, Bo; Tan, Zhulin; Song, Jinhua J. 分享 收藏 Process Development for the Synthesis of BI 1702135: A Concise Design Enabled by Selective Acylation of a 2-Aminobenzimidazole IntermediateWu, Jiang-Ping; Dong, Wei-Tong; Chen, Chengsheng; Sienkiewicz, Alexander; Beyer, Phouvieng; Wang, Jun; Haddad, Nizar; Lorenz, Jon C.; Reeves, Jonathan T.; Bunner, Matthew H.; Gonnella, Nina C.; Weinstabl, Harald; Garavel, Geraldine 分享 收藏 Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin)Frutos, Rogelio; Tampone, Thomas G.; Mulder, Jason; Gao, Joe; Sieber, Joshua D.; Rodriguez, Sonia; Haddad, Nizar; Baer, Katrin; Brown, Jack; Yang, Bing-Shiou; Giovannini, Riccardo; Song, Jinhua J.; Grinberg, Nelu; Lee, Heewon; Senanayake, Chris H. 分享 收藏 Process Development of the BACE Inhibitors BI 1147560 BS and BI 1181181 MZLi, Guisheng; Tan, Zhulin; Xu, Yibo; Sidhu, Kanwar P. S.; Qu, Bo; Herbage, Melissa A.; Eriksson, Magnus C.; Zeng, Xingzhong; Busacca, Carl A.; Desrosiers, Jean-Nicolas; Hampel, Thomas; Niemeier, Oliver; Reichel, Carsten; Dang, Mai Thi Quynh; Schoerer, Marvin; Kemmer, Dirk; Eick, Melanie; Werle, Holger; Kim, Soojin; Li, Zhibin; Venkatraman, Shankar; Jia, Lanqi; Claremon, David A.; Fuchs, Klaus; Heine, Niklas; Byrne, Denis; Narayanan, Bikshandarkoil; Sarvestani, Max; Johnson, Joe; Premasiri, Ajith; Nummy, Larry J.; Lorenz, Jon C.; Haddad, Nizar; Gonnella, Nina C.; Pennino, Scott; Krawiec, Mariusz; Senanayake, Chris H.; Buono, Frederic; Lee, Heewon; Hossain, Azad; Song, Jinhua J.; Reeves, Jonathan T. 分享 收藏 Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C-N CouplingQu, Bo; Lee, Jaehee; Wu, Lifen; Saha, Anjan K.; Li, Guisheng; Xu, Yibo; Tan, Zhulin; Brazzillo, Jason; Haddad, Nizar; Pennino, Scott; Rodriguez, Sonia; Lorenz, Jon C.; Frutos, Rogelio; Sidhu, Kanwar P. S.; Wang, Xiao-Jun; Zhang, Yongda; Senanayake, Chris H.; Song, Jinhua J. 分享 收藏 分享 收藏 Discovery and Process Development of a Scalable Biocatalytic Kinetic Resolution toward Synthesis of a Sterically Hindered Chiral KetoneWamser, Nicole; Wu, Hao; Buono, Frederic; Brundage, Anthony; Ricci, Francesco; Lorenz, Jon C.; Wang, Jun; Haddad, Nizar; Paolillo, Joshua; Leung, Joyce C.; Lee, Heewon; Hossain, Azad 分享 收藏 Large-Scale Enantioselective Reduction of 2,3-Disubstituted Indenopyridine Enables a Practical Manufacturing Process for an 11β-HSD-1 InhibitorQu, Bo; Wei, Xudong; Zeng, Xingzhong; Yang, Bing-Shiou; Desrosiers, Jean-Nicolas; Savoie, Jolaine; Wang, Jun; Marsini, Maurice A.; Li, Zhibin; Haddad, Nizar; Lorenz, Jon C.; Tielmann, Patrick; Maier, Nora; Song, Jinhua J.; Senanayake, Chris H. 分享 收藏 分享 收藏 Large Scale Practical Synthesis of Enantiomerically Pure cis-4-Amino-3-fluoro-1-methylpiperidine via Rhodium-Catalyzed Asymmetric Hydrogenation of a Tetrasubstituted Fluoroalkene通过铑催化的四取代氟代烯烃的不对称氢化大规模实际合成对映体纯cis-4-Amino-3-fluoro-1-methylpiperidineQu, Bo; Saha, Anjan; Li, Guisheng; Zeng, Xingzhong; Wang, Xiaojun; Haddad, Nizar; Hou, Xiaowen; Lorenz, Jon C.; Wu, Lifen; Pennino, Scott; Lee, Heewon; Song, Jinhua J.; Senanayake, Chris H. 分享 收藏 Sulfone-Mediated SNAr Reaction as a Powerful Tool for the Synthesis of 4-Quinolinyl Ethers and More-Application to the Synthesis of HCV NS3/4a Protease Inhibitor BI 201420Patel, Nitinchandra D.; Wei, Xudong; Byrne, Denis; Narayanan, Bikshandarkoil A.; Pennino, Scott; Sarvestani, Max; Saha, Anjan; Haddad, Nizar; Kapadia, Suresh; Lorenz, Jon C.; DeCroos, Philomen; Ye, Andrew; Lee, Heewon; Grinberg, Nelu; Hossain, Azad; Busacca, Carl A.; Yee, Nathan K.; Senanayake, Chris H. 分享 收藏 分享 收藏 Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase InhibitorsEngelhardt, Harald; Boese, Dietrich; Petronczki, Mark; Scharn, Dirk; Bader, Gerd; Baum, Anke; Bergner, Andreas; Chong, Eugene; Doebel, Sandra; Egger, Georg; Engelhardt, Christian; Ettmayer, Peter; Fuchs, Julian E.; Gerstberger, Thomas; Gonnella, Nina; Grimm, Andreas; Grondal, Elisabeth; Haddad, Nizar; Hopfgartner, Barbara; Kousek, Roland; Krawiec, Mariusz; Kriz, Monika; Lamarre, Lyne; Leung, Joyce; Mayer, Moriz; Patel, Nitinchandra D.; Simov, Biljana Peric; Reeves, Jonathan T.; Schnitzer, Renate; Schrenk, Andreas; Sharps, Bernadette; Solca, Flavio; Stadtmueller, Heinz; Tan, Zhulin; Wunberg, Tobias; Zoephel, Andreas; McConnell, Darryl B. 分享 收藏 分享 收藏 Application of a Preformed Pd-BIDIME Precatalyst to Suzuki-Miyaura Cross-Coupling Reaction in FlowSieber, Joshua D.; Buono, Frederic; Brusoe, Andrew; Desrosiers, Jean-Nicolas; Haddad, Nizar; Lorenz, Jon C.; Xu, Yibo; Wu, Hao; Zhang, Li; Han, Zhengxu Steve; Roschangar, Frank; Song, Jinhua J.; Yee, Nathan K.; Senanayake, Chris H. 分享 收藏 Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki Miyaura and Negishi Cross-Coupling Reactions for Tetra-ortho-Substituted Biaryl Synthesis (vol 8, pg 10190, 2018)Patel, Nitinchandra D.; Sieber, Joshua D.; Tcyrulnikov, Sergei; Simmons, Bryan J.; Rivalti, Daniel; Duvvuri, Krishnaja; Zhang, Yongda; Gao, Donghong A.; Fandrick, Keith R.; Haddad, Nizar; Lao, Kendricks So; Mangunuru, Hari P. R.; Biswas, Soumik; Qu, Bo; Grinberg, Nelu; Pennino, Scott; Lee, Heewon; Song, Jinhua J.; Gupton, Frank; Garg, Neil K.; Kozlowski, Marisa C.; Senanayake, Chris H. 分享 收藏 
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