未登录 分享 收藏
分享 收藏
Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A Wortmann, Lars; Braeuer, Nico; Holton, Simon J.; Irlbacher, Horst; Weiske, Joerg; Lechner, Christian; Meier, Robin; Karen, Jakob; Sioeberg, Catrine Berthold; Puetter, Vera; Christ, Clara D.; ter Laak, Antonius; Lienau, Philip; Lesche, Ralf; Nicke, Barbara; Cheung, Shing-Hu; Bauser, Marcus; Haegebarth, Andrea; von Nussbaum, Franz; Mumberg, Dominik; Lemos, Clara 分享 收藏
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models Lemos, Clara; Schulze, Volker K.; Baumgart, Simon J.; Nevedomskaya, Ekaterina; Heinrich, Tobias; Lefranc, Julien; Bader, Benjamin; Christ, Clara D.; Briem, Hans; Kuhnke, Lara P.; Holton, Simon J.; Bomer, Ulf; Lienau, Philip; von Nussbaum, Franz; Nising, Carl F.; Bauser, Marcus; Haegebarth, Andrea; Mumberg, Dominik; Haendler, Bernard 分享 收藏
分享 收藏
Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C Mortier, Jeremie; Friberg, Anders; Badock, Volker; Moosmayer, Dieter; Schroeder, Jens; Steigemann, Patrick; Siegel, Franziska; Gradl, Stefan; Bauser, Marcus; Hillig, Roman C.; Briem, Hans; Eis, Knut; Bader, Benjamin; Nguyen, Duy; Christ, Clara D. 分享 收藏
Discovery and characterization of BAY-6035, a novel benzodiazepine-based SMYD3 inhibitor Gradl, Stefan; Steuber, Holger; Weiske, Joerg; Schmees, Norbert; Siegel, Stephan; Stoeckigt, Detlef; Christ, Clara D.; Li, Fengling; Organ, Shawna; Barsyte-Lovejoy, Dalia; Szewczyk, Magdalena M.; Kennedy, Steven; Trush, Viacheslav; Vedadi, Masoud; Arrowsmith, Cheryl H.; Brown, Peter J.; Husemann, Manfred; Fernandez-Montalvan, Amaury E.; Badock, Volker; Bauser, Marcus; Haegebarth, Andrea; Hartung, Ingo V.; Stresemann, Carlo 分享 收藏
BAY-3827, a selective inhibitor of AMPK for the evaluation of the role of AMPK in Myc-dependent tumors Lemos, Clara; Schulze, Volker K.; Bader, Benjamin; Christ, Clara D.; Briem, Hans; Politz, Oliver; Prinz, Florian; Holton, Simon; Heinrich, Tobias; Lefranc, Julien; Lienau, Philip; Scholz, Arne; von Nussbaum, Franz; Nising, Carl Friedrich; Mumberg, Dominik; Bauser, Marcus; Haegebarth, Andrea 分享 收藏
分享 收藏
BAY-299, a novel chemical probe for in-depth analysis of the function of the bromodomain proteins BRPF2 and TAF1 Bouche, Lea; Christ, Clara D.; Siegel, Stephan; Tallant, Cynthia; Fernandez-Montalvan, Amaury E.; Huber, Kilian V.; Putter, Verra; Mueller, Susanne; Fedorov, Oleg; ter Laak, Antonius; Sugawara, Tatsuo; Stockigt, Detlef; Meier, Julia; Holton, Simon J.; Hartung, Ingo V.; Haendler, Bernard 分享 收藏
Probing the cancer epigenome: empowering target validation by open innovation Hartung, Ingo V.; Arrowsmith, Cheryl; Badock, Volker; Barak, Naomi; Berger, Markus; Brown, Peter J.; Christ, Clara D.; Eggert, Erik; Egner, Ursula; Fedorov, Oleg; Fernandez-Montalvan, Amaury E.; Gorjanacz, Matyas; Haegebarth, Andrea; Haendler, Bernard; Hillig, Roman C.; Holton, Simon H.; Huber, Kilian V.; Koo, Seong J.; ter Laak, Antonius; Mueller, Susanne; Mueller-Fahrnow, Anke; Scholten, Cora; Siegel, Stephan; Stellfeld, Timo; Stoeckigt, Detlef; Stresemann, Carlo; Vedadi, Masoud; Weiske, Joerg; Weinmann, Hilmar 分享 收藏
Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains 苯并异喹啉二酮作为BRPF2和TAF1/TAF1L溴结构域的有效和选择性抑制剂 Bouche, Lea; Christ, Clara D.; Siegel, Stephan; Fernandez-Montalvan, Amaury E.; Holton, Simon J.; Fedorov, Oleg; ter Laak, Antonius; Sugawara, Tatsuo; Stoeckigt, Detlef; Tallant, Cynthia; Bennett, James; Monteiro, Octovia; Diaz-Saez, Laura; Siejka, Paulina; Meier, Julia; Puetter, Vera; Weiske, Joerg; Mueller, Susanne; Huber, Kilian V. M.; Hartung, Ingo V.; Haendler, Bernard 分享 收藏
Collaborating to improve the use of free-energy and other quantitative methods in drug discovery Sherborne, Bradley; Shanmugasundaram, Veerabahu; Cheng, Alan C.; Christ, Clara D.; DesJarlais, Renee L.; Duca, Jose S.; Lewis, Richard A.; Loughney, Deborah A.; Manas, Eric S.; McGaughey, Georgia B.; Peishoff, Catherine E.; van Vlijmen, Herman 分享 收藏
Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2 蛋白质赖氨酸甲基转移酶SMYD2的高效和选择性的基于氨基吡唑啉的体内探针 (598) 的发现和表征 Eggert, Erik; Hillig, Roman C.; Koehr, Silke; Stoeckigt, Detlef; Weiske, Joerg; Barak, Naomi; Mowat, Jeffrey; Brumby, Thomas; Christ, Clara D.; ter Laak, Antonius; Lang, Tina; Fernandez-Montalvan, Amaury E.; Badock, Volker; Weinmann, Hilmar; Hartung, Ingo V.; Barsyte-Lovejoy, Dalia; Szewczyk, Magdalena; Kennedy, Steven; Li, Fengling; Vedadi, Masoud; Brown, Peter J.; Santhakumar, Vijayaratnam; Arrowsmith, Cheryl H.; Stellfeld, Timo; Stresemann, Carlo 分享 收藏
Discovery and in vitro and in vivo characterization of aminopyrazoline-based SMYD2 inhibitors Stresemann, Carlo; Hartung, Ingo; Stellfeld, Timo; Barak, Naomi; Mowat, Jeffrey; Christ, Clara; ter Laak, Antonius; Koehr, Silke; Weiske, Joerg; Hillig, Roman; Badock, Volker; Stoeckigt, Detlef; Ziegelbauer, Karl; Weinmann, Hilmar; Gekeler, Volker 分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
