未登录 Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors Benediktsdottir, Andrea; Sooriyaarachchi, Sanjeewani; Cao, Sha; Ottosson, Nina E.; Lindstrom, Stefan; Lundgren, Bo; Kloditz, Katharina; Lola, Daina; Bobileva, Olga; Loza, Einars; Hughes, Diarmaid; Jones, T. Alwyn; Mowbray, Sherry L.; Zamaratski, Edouard; Sandstrom, Anja; Karlen, Anders 分享 收藏
Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria 具有有效体内活性的抗生素类靶向革兰氏阴性细菌中的脂多糖合成 Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani; Ahmad, Shabbir; Bergfors, Terese; Krasnova, Laura; Pelss, Juris; Ikaunieks, Martins; Loza, Einars; Katkevics, Martins; Bobileva, Olga; Cirule, Helena; Gukalova, Baiba; Grinberga, Solveiga; Backlund, Maria; Simoff, Ivailo; Leber, Anna T.; Berruga-Fernandez, Talia; Antonov, Dmitry; Konda, Vivekananda R.; Lindstrom, Stefan; Olanders, Gustav; Brandt, Peter; Baranczewski, Pawel; Lundberg, Carina Vingsbo; Liepinsh, Edgars; Suna, Edgars; Jones, T. Alwyn; Mowbray, Sherry L.; Hughes, Diarmaid; Karlen, Anders 分享 收藏
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Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule Grinkevich, Vera V.; Vema, Aparna; Fawkner, Karin; Issaeva, Natalia; Andreotti, Virginia; Dickinson, Eleanor R.; Hedstrom, Elisabeth; Spinnler, Clemens; Inga, Alberto; Larsson, Lars-Gunnar; Karlen, Anders; Wilhelm, Margareta; Barran, Perdita E.; Okorokov, Andrei L.; Selivanova, Galina; Zawacka-Pankau, Joanna E. 分享 收藏
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Towards the sustainable discovery and development of new antibiotics 走向新抗生素的可持续发现和开发 Miethke, Marcus; Pieroni, Marco; Weber, Tilmann; Bronstrup, Mark; Hammann, Peter; Halby, Ludovic; Arimondo, Paola B.; Glaser, Philippe; Aigle, Bertrand; Bode, Helge B.; Moreira, Rui; Li, Yanyan; Luzhetskyy, Andriy; Medema, Marnix H.; Pernodet, Jean-Luc; Stadler, Marc; Tormo, Jose Ruben; Genilloud, Olga; Truman, Andrew W.; Weissman, Kira J.; Takano, Eriko; Sabatini, Stefano; Stegmann, Evi; Brotz-Oesterhelt, Heike; Wohlleben, Wolfgang; Seemann, Myriam; Empting, Martin; Hirsch, Anna K. H.; Loretz, Brigitta; Lehr, Claus-Michael; Titz, Alexander; Herrmann, Jennifer; Jaeger, Timo; Alt, Silke; Hesterkamp, Thomas; Winterhalter, Mathias; Schiefer, Andrea; Pfarr, Kenneth; Hoerauf, Achim; Graz, Heather; Graz, Michael; Lindvall, Mika; Ramurthy, Savithri; Karlen, Anders; van Dongen, Maarten; Petkovic, Hrvoje; Keller, Andreas; Peyrane, Frederic; Donadio, Stefano; Fraisse, Laurent; Piddock, Laura J. V.; Gilbert, Ian H.; Moser, Heinz E.; Muller, Rolf 分享 收藏
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Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase 硼酸酯连接的大环脂肽作为靶向大肠杆菌I型信号肽酶的丝氨酸蛋白酶抑制剂 Szalaj, Natalia; Lu, Lu; Benediktsdottir, Andrea; Zamaratski, Edouard; Cao, Sha; Olanders, Gustav; Hedgecock, Charles; Karlen, Anders; Erdelyi, Mate; Hughes, Diarmaid; Mowbray, Sherry L.; Brandt, Peter 分享 收藏
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Design, synthesis and in vitro biological evaluation of oligopeptides targeting E-coli type I signal peptidase (LepB) 靶向大肠杆菌I型信号肽酶 (LepB) 的寡肽的设计、合成及体外生物学评价 De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szalaj, Natalia; Cao, Sha; Wadensten, Henrik; Lenhammar, Lena; Gising, Johan; Roos, Annette K.; Huseby, Douglas L.; Larsson, Rolf; Andren, Per E.; Hughes, Diarmaid; Brandt, Peter; Mowbray, Sherry L.; Karlen, Anders 分享 收藏
The Innovative Medicines Initiative's New Drugs for Bad Bugs programme: European public-private partnerships for the development of new strategies to tackle antibiotic resistance Kostyanev, T.; Bonten, M. J. M.; O'Brien, S.; Steel, H.; Ross, S.; Francois, B.; Tacconelli, E.; Winterhalter, M.; Stavenger, R. A.; Karlen, A.; Harbarth, S.; Hackett, J.; Jafri, H. S.; Vuong, C.; MacGowan, A.; Witschi, A.; Angyalosi, G.; Elborn, J. S.; dewinter, R.; Goossens, H. 分享 收藏
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Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2-P1′ Region 跨P2-P1区的新型拟肽丙型肝炎病毒NS3/4A蛋白酶抑制剂 Lampa, Anna K.; Bergman, Sara M.; Gustafsson, Sofia S.; Alogheli, Hiba; Akerblom, Eva B.; Lindeberg, Gunnar G.; Svensson, Richard M.; Artursson, Per; Danielson, U. Helena; Karlen, Anders; Sandstrom, Anja 分享 收藏
DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues Jansson, Anna M.; Wieckowska, Anna; Bjorkelid, Christofer; Yahiaoui, Samir; Sooriyaarachchi, Sanjeewani; Lindh, Martin; Bergfors, Terese; Dharavath, Shyamraj; Desroses, Matthieu; Suresh, Surisetti; Andaloussi, Mounir; Nikhil, Rautela; Sreevalli, Sharma; Srinivasa, Bachally R.; Larhed, Mats; Jones, T. Alwyn; Karlen, Anders; Mowbray, Sherry L. 分享 收藏
Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket Gising, Johan; Belfrage, Anna Karin; Alogheli, Hiba; Ehrenberg, Angelica; Akerblom, Eva; Svensson, Richard; Artursson, Per; Karlen, Anders; Danielson, U. Helena; Larhed, Mats; Sandstrom, Anja 分享 收藏
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