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葛

葛广波 (Guangbo Ge)

Shanghai University of Traditional Chinese Medicine

24H指数
114论文数
1.8K被引数
收录论文 52
发表时间
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Oridonin exerts dual therapeutic effects in MASLD mice by integrating lipid homeostasis and drug bioactivation via the LXRα–CES1/CES2 pathwayOridonin在MASLD小鼠中通过LXRα–CES1/CES2通路整合脂质稳态和药物生物活化发挥双重治疗作用。
errActa Pharmacologica Sinica
IF8.4
err2026-02-04
err0
PREAI
errHuan-guo Jiang; Zhi-kun Zhan; Ling-min Tian; Yu-lian Chen; Mei-qun Cai; Guang-bo Ge; Xin Chen; Chuan-liang Wei; Lan Tang
err分享
err收藏
Marine-Derived Bromotyrosine Alkaloids as Potent hCYP1B1 Inhibitors to Overcome Paclitaxel Resistance
errJournal of Medicinal Chemistry
IF6.8
err2026-01-30
err0
PREAI
errQuan Xu; Yuan Xiong; Yanfen Fang; Bei Zhao; Biyu Yang; Yu-Meng Hao; Hong-Xia Dai; Xiangyang Zhang; Yi Chen; Guang-Bo Ge; Xu-Wen Li
err分享
err收藏
Compound Yujie decoction ameliorates LPS-induced acute lung injury by suppressing NLRP3 inflammasome-mediated macrophage pyroptosisCompound Yujie decoction ameliorates LPS-induced acute lung injury by suppressing NLRP3 inflammasome-mediated macrophage pyroptosis 复方玉枳汤通过抑制NLRP3炎性小体介导的巨噬细胞焦亡，改善LPS诱导的急性肺损伤。
errJournal of Ethnopharmacology
IF5.4
err2025-12-16
err0
PREAI
errYuhui Ma; Tian Tian; Jialei Meng; Shenglan Qi; Lanhui Qin; Kailiang Xu; Lijiao You; Yanxu Chang; Wei Liu; Guangbo Ge; Ming Lei
err分享
err收藏
Corrigendum to “Macrophage-targeted polysaccharide nano-immunomodulators with spatial- and time-programmed drug release for cancer therapy” [Nano Today 66 (2026) 102893]勘误：针对“用于癌症治疗的巨噬细胞靶向多糖纳米免疫调节剂及其空间和时间编程药物释放”[Nano Today 66 (2026) 102893]
errNano Today
IF10.9
err2025-10-04
err0
PREAI
errLi Xu; Jiaqian Miao; Danni Xu; Xuan Mo; Junjie Wang; Sisi Chen; Bing Liu; Guangbo Ge; Xinyuan Zhu; Hongping Deng
err分享
err收藏
The regulatory roles of pparα on hepatic drug-metabolizing enzymes in primary sclerosing cholangitis Syrian hamstersPPARα对原发性硬化性胆管炎叙利亚仓鼠肝脏药物代谢酶的调控作用
errBiochemical Pharmacology
IF5.6
err2025-09-13
err0
PREAI
errShuaibing Liu; Jinxin Miao; Hang Li; Guangbo Ge; Quanjun Yang; Songfeng Zhao; Cheng Guo
err分享
err收藏
Covalent inhibitors of human cytochrome P450 3A4: research advances and future perspectives人源细胞色素P450 3A4的共价抑制剂：研究进展与未来展望
errCoordination Chemistry Reviews
IF23.5
err2025-08-12
err0
PREAI
errDong-Zhu Tu; Zhang-Ping Xiao; Shu-Yan Liu; Xue-Yan Hu; Jing-Xuan Lei; Jia-Hao Gong; Feng Zhang; Xin-Xin Ding; Zi-Ru Dai; Jiang Zheng; Ling Yang; Guang-Bo Ge
err分享
err收藏
Thiazole-fused thiazoliniums with ketone warheads as covalent inhibitors targeting Cys44 of SARS-CoV-2 3CLpro噻唑并噻唑啉鎓类化合物，其含有酮类弹头，作为靶向SARS-CoV-2 3CLpro蛋白Cys44位点的共价抑制剂。
errChemico-Biological Interactions
IF5.4
err2025-06-24
err0
PREAI
errQizhen Cao; Zhaoqin Zhang; Guanghao Zhu; Sanfeng Dong; Xue Sun; Yuqing Song; Ya Zhang; Tingting Cai; Xinben Zhang; Yong Zhang; Zhijian Xu; Ruisheng Xiong; Weiliang Zhu; Guangbo Ge; Bo Li
err分享
err收藏
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis从中药中高效发现强效抗骨质疏松剂，用于对抗糖皮质激素诱导的骨质疏松。药学学报
errActa Pharmaceutica Sinica B
IF14.6
err2025-06-09
err0
errOAAI
errYuqing Song; Feng Zhang; Jia Guo; Yufan Fan; Hairong Zeng; Mengru Sun; Jun Qian; Shenglan Qi; Zihan Chen; Xudong Jin; Yunqing Song; Tian Tian; Zhi Qian; Yao Sun; Zhenhao Tian; Baoqing Yu; Guangbo Ge
err分享
err收藏
Rationally engineered a universal far-red fluorogenic substrate of bile salt hydrolase for functional imaging and inhibitor screening理性设计了一种适用于胆盐水解酶的功能成像和抑制剂筛选的通用远红荧光底物
errChinese Chemical Letters
IF8.9
err2025-05-15
err0
PREAI
errWenchao Chen; Xiaoting Niu; Xinyu Liang; Guanghao Zhu; Xue Zhang; Qing Gong; Cen Xie; Guangbo Ge; Ping Wang; Yuqi He
err分享
err收藏
Human cytochrome P450 enzymes catalyze oxidative metabolism of pectolinarigenin to generate a more active Nrf2 agonist人细胞色素P450酶催化对芹黄素进行氧化代谢，生成一种活性更强的Nrf2激动剂
errChinese Herbal Medicines
IF8.9
err2025-05-01
err0
errOAAI
errPeiqi Liu; Yanyan Deng; Dongzhu Tu; Jiahao Gong; Feng Zhang; Huixin Liu; Qian Li; Jing Hu; Guangbo Ge
err分享
err收藏
Rational engineering of an optimized near-infrared fluorogenic sensor for efficient discovery of potent Notum inhibitors as anti-osteoporosis agents
errSENSORS AND ACTUATORS B-CHEMICAL
IF7.7
err2025-05-01
err0
PREAI
errLiu, Lele; Fan, Yufan; Lin, Hong; Lei, Jingxuan; Guo, Jia; Chen, Lin; Xiao, Zhangping; Song, Yunqing; Yang, Xiaodi; Ge, Guangbo; Tang, Hui
err分享
err收藏
Discovery of anthraquinones as potent Notum inhibitors for treating osteoporosis by integrating biochemical, phytochemical, computational, and experimental assays通过整合生化、植物化学、计算和实验方法发现蒽醌类化合物作为治疗骨质疏松症的强效Notum抑制剂
errJournal of Pharmaceutical Analysis
IF8.9
err2025-03-05
err0
errOAAI
errJia Guo; Yuqing Song; Mengru Sun; Jun Qian; Dihang See; Tian Tian; Yunqing Song; Wei Liu; Hongping Deng; Yao Sun; Guangbo Ge; Yongfang Zhao
err分享
err收藏
A patent review of CYP3A4 inhibitors (2018-present)
errEXPERT OPINION ON THERAPEUTIC PATENTS
IF4.6
err2025-02-24
err0
PREAI
errTu, Dong-Zhu; Hu, Xue-Yan; Lei, Jing-Xuan; Liu, Shu-Yan; Xiao, Zhang-Ping; Yang, Ling; Ge, Guang-Bo
err分享
err收藏
Uncovering the covalent inhibitors of SARS-CoV-2 Mpro in Tibetan edible herb Rhodiola crenulata and their synergistic anti-Mpro mechanism揭示藏食药植物红景天中SARS-CoV-2 Mpro共价抑制剂的协同抗Mpro机制
errJournal of Pharmaceutical Analysis
IF8.9
err2025-02-08
err0
errOAAI
errGuang-Hao Zhu; Ya-Ni Zhang; Yuan Xiong; Xu-Dong Hou; Qing-Guang Zhang; Zhao-Qin Zhang; Xiao-Yu Zhuang; Wei-Dong Zhang; Guang-Bo Ge
err分享
err收藏
Rationally engineered IR-783 octanoate as an enzyme-activatable fluorogenic tool for functional imaging of hNotum in living systems
errCHINESE CHEMICAL LETTERS
IF8.9
err2024-11-01
err1
PREAI
errSong, Lilin; Sun, Mengru; Song, Yuqing; Zhang, Feng; Zhao, Bei; Zeng, Hairong; Shi, Jinhui; Liu, Huixin; Zhao, Shanshan; Tian, Tian; Yin, Heng; Ge, Guangbo
err分享
err收藏
Activity-based NIR specific fluorescent probe reveals the abnormal elevation of prolyl endopeptidase in hippocampus during Alzheimer's disease progression基于活性的NIR特异性荧光探针揭示阿尔茨海默病进展过程中海马中脯氨酰内肽酶的异常升高
errSENSORS AND ACTUATORS B-CHEMICAL
IF7.7
err2024-10-01
err0
PREAI
errLi, Hao; Bian, Kun-Jie; Wang, Xiu-Yang; Li, Xiao-Dong; Song, Pei-Fang; Yu, Chun-Yang; Ge, Guang-Bo; Qian, Xing-Kai; Zou, Li-Wei; Zhou, Yong-Feng; Yang, Ling
err分享
err收藏
Discovery and characterization of naturally occurring covalent inhibitors of SARS-CoV-2 Mpro from the antiviral herb Ephedra抗病毒药麻黄中天然存在的SARS-CoV-2 Mpro共价抑制剂的发现和表征
errCHINESE JOURNAL OF NATURAL MEDICINES
IF4.9
err2024-09-01
err0
PREAI
errQing, Hu; Zhang, Yiwen; Chen, Pengcheng; Zhang, Yani; Zhu, Guanghao; Liu, Wei; Wang, Chaoran; Zheng, Shuilian; Shen, Nonger; Wang, Haonan; Huang, Ping; Ge, Guangbo
err分享
err收藏
Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis
errMOLECULAR CANCER
IF33.9
err2024-08-20
err1
errOAAI
errZhou, Jing; Song, Qing; Li, Haoze; Han, Yicun; Pu, Yunzhou; Li, Ling; Rong, Wenqing; Liu, Xiaodie; Wang, Ziyuan; Sun, Jian; Song, Yuqing; Hu, Xueyan; Zhu, Guanghao; Zhu, Huirong; Yang, Liu; Ge, Guangbo; Li, Hongshan; Ji, Qing
err分享
err收藏
Pectolinarigenin ameliorates osteoporosis via enhancing Wnt signaling cascade in PPARβ-dependent manner
errPHYTOMEDICINE
IF8.3
err2024-07-01
err0
PREAI
errQian, Jun; Li, Qian; Song, Yangjie; Gong, Xuyan; Hu, Kaili; Ge, Guangbo; Sun, Yao
err分享
err收藏
RNA binding protein RALY facilitates colorectal cancer metastasis via enhancing exosome biogenesis in m6A dependent manner
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2024-07-01
err0
errOAAI
errZhou, Jing; Li, Ling; Han, Yicun; Ge, Guangbo; Ji, Qing; Li, Hongshan
err分享
err收藏

研究方向

药物筛选与评价新技术研究蛋白特异性功能探针研发及其应用基础研究外源物与代谢酶相互作用研究
合作学者
合作期刊
F
Frank J. Gonzalez
H 指数: 191 · 论文数: 1.7K
陈
陈宸 (Chen Chen)
H 指数: 108 · 论文数: 3.9K
张峰 封面图
张峰 (Feng Zhang)
H 指数: 91 · 论文数: 1.2K
王
王志伟 (Zhiwei Wang)
H 指数: 89 · 论文数: 993
韦
韦世强 (Shiqiang Wei)
H 指数: 87 · 论文数: 460
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