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K

K.W. Nettles

the herbert wertheim uf scripps institute for biomedical innovation and technology
H指数:34
被引数:3,831

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Chloroindazole based estrogen receptor β ligands with favorable pharmacokinetics promote functional remyelination and visual recovery

基于Chloroindazole的雌激素受体β配体，具有有利的药代动力学特性，可促进功能性髓鞘再生和视觉恢复

Scientific Reports
IF3.9
2025-10-080
OA
Micah Feri; Sung Hoon Kim; Flavio D. Cardenas; Alyssa M. Anderson; Brandon T. Poole; Devang Deshpande; Shane Desfor; Kelley C. Atkinson; Stephanie R. Peterson; Kendall W. Nettles; Jerome C. Nwachukwu; Moyinoluwa T. Ajayi; Fernando Beltran; David E. Martin; Julio Tapia; Carol D. Curtis; Martin I. Garcia-Castro; Benita S. Katzenellenbogen; John A. Katzenellenbogen; Seema K. Tiwari-Woodruff
Benzestrol Isomer Stereochemistry Determines the Distinct Estrogenic Activities and Conformations of the Eight Isomers When Bound to Estrogen Receptor α

苯雌酚异构体立体化学决定了当其与雌激素受体α结合时，八种异构体具有不同的雌激素活性和构象。

ACS Pharmacology & Translational Science
IF3.7
2025-07-090
OA
Yingwei Hou; Jerome C. Nwachukwu; Kathryn Carlson; Sung Hoon Kim; Samantha Angle; Eric N. Jacobsen; Toby Woods; Sofia L. Mateus; Sean W. Fanning; Yvonne Ziegler; Benita S. Katzenellenbogen; Kendall W. Nettles; John A. Katzenellenbogen
Estrogen Receptor Mutants with Endocrine Therapies Stabilize Multiple Receptor Antagonist Substates to Drive Efficacy and Resistance

雌激素受体突变体与内分泌疗法能稳定多种受体拮抗剂亚状态，以驱动疗效和耐药性。

ENDOCRINOLOGY
IF3.3
2025-04-210
PRE
Fanning, Sean William; Hou, Yingwei; Izard, Tina; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.; Kim, Sung Hoon; Kobylski, Robin Russo; Min, Charles; Nettles, Kendall W.; Nwachukwu, Jerome; Papa, Alexandra; Ziegler, Yvonne
Native top-down proteomics enables discovery in endocrine-resistant breast cancer

本土自上而下蛋白质组学实现了内分泌抵抗性乳腺癌的发现

NATURE CHEMICAL BIOLOGY
IF13.7
2025-04-040
PRE
Gomes, Fabio P.; Durbin, Kenneth R.; Schauer, Kevin; Nwachukwu, Jerome C.; R. Kobylski, Robin; Njeri, Jacqline W.; Seath, Ciaran P.; Saviola, Anthony J.; McClatchy, Daniel B.; Diedrich, Jolene K.; Garrett, Patrick T.; Papa, Alexandra B.; Ciolacu, Ianis; Kelleher, Neil L.; Nettles, Kendall W.; Yates III, John R.
Physiologic and structural characterization of desisobutyryl-ciclesonide, a selective glucocorticoid receptor modulator in newborn rats
PNAS NEXUS
IF3.8
2024-12-260
OAAI
Jaumotte, Juliann D.; El Khoury, Nathalie; Min, Charles K.; Wang, Jiefei; Madigan, Caroline; Jano, Antalya; Kobylski, Robin J. Russo; Solt, Laura A.; Dhavan, Rutu S.; Short, Kelly L.; Lei, Tianhua; Chandran, Uma; Cole, Timothy J.; Monaghan-Nichols, Ann Paula; Sampath, Venkatesh; Houtman, Rene; Nettles, Kendall W.; Defranco, Donald B.
Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu

雌激素受体-α 同型二聚体中的不对称变构驱动对激素环境中雌激素集合的反应

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2024-06-031
OAAI
Min, Charles K.; Nwachukwu, Jerome C.; Hou, Yingwei; Russo, Robin J.; Papa, Alexandra; Min, Jian; Peng, Rouming; Kim, Sung Hoon; Ziegler, Yvonne; Rangarajan, Erumbi S.; Izard, Tina; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.; Nettles, Kendall W.
Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors

碳酸酐酶和雌激素受体双重调节剂的设计、合成、生物学评价及晶体结构测定

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2023-01-014
OAAI
Tinivella, Annachiara; Nwachukwu, Jerome C.; Angeli, Andrea; Foschi, Francesca; Benatti, Anna Laura; Pinzi, Luca; Izard, Tina; Ferraroni, Marta; Erumbi, Rangarajan; Christodoulou, Michael S.; Passarella, Daniele; Supuran, Claudiu T.; Nettles, Kendall W.; Rastelli, Giulio
The SARS-CoV-2 spike protein binds and modulates estrogen receptors
SCIENCE ADVANCES
IF12.5
2022-12-0213
OAAI
Solis, Oscar; Beccari, Andrea R.; Iaconis, Daniela; Talarico, Carmine; Ruiz-Bedoya, Camilo A.; Nwachukwu, Jerome C.; Cimini, Annamaria; Castelli, Vanessa; Bertini, Riccardo; Montopoli, Monica; Cocetta, Veronica; Borocci, Stefano; Prandi, Ingrid G.; Flavahan, Kelly; Bahr, Melissa; Napiorkowski, Anna; Chillemi, Giovanni; Ooka, Masato; Yang, Xiaoping; Zhang, Shiliang; Xia, Menghang; Zheng, Wei; Bonaventura, Jordi; Pomper, Martin G.; Hooper, Jody E.; Morales, Marisela; Rosenberg, Avi Z.; Nettles, Kendall W.; Jain, Sanjay K.; Allegretti, Marcello; Michaelides, Michael
Dual-mechanism estrogen receptor inhibitors

双机制雌激素受体抑制剂

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2021-08-2714
OA
Min, Jian; Nwachukwu, Jerome C.; Min, Charles K.; Njeri, Jacqline W.; Srinivasan, Sathish; Rangarajan, Erumbi S.; Nettles, Charles C.; Guillen, Valeria Sanabria; Ziegler, Yvonne; Yan, Shunchao; Carlson, Kathryn E.; Hou, Yingwei; Kim, Sung Hoon; Novick, Scott; Pascal, Bruce D.; Houtman, Rene; Griffin, Patrick R.; Izard, Tina; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.; Nettles, Kendall W.

研究方向

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J
J.C. Nwachukwu
H 指数:23论文数:152被引数:1,768
J
John A. Katzenellenbogen
H 指数:100论文数:1,034被引数:4.2万
B
Benita S. Katzenellenbogen
H 指数:114论文数:498被引数:3.9万
S
Sathish Srinivasan
H 指数:33论文数:223被引数:3,519
J
Jason Nowak
H 指数:16论文数:52被引数:1,496
K
Kathryn E. Carlson
H 指数:51论文数:194被引数:1.0万
J
Jian Min
H 指数:21论文数:71被引数:1,705
G
Geoffrey L. Greene
H 指数:82论文数:576被引数:3.3万
T
Tina Izard
H 指数:38论文数:157被引数:6,778
S
Sung Hoon Kim
H 指数:24论文数:89被引数:2,243