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Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-κB and snail Kim, Hyun-Jung; Litzenburger, Beate C.; Cui, Xiaojiang; Delgado, David A.; Grabiner, Brian C.; Lin, Xin; Lewis, Michael T.; Gottardis, Marco M.; Wong, Tai W.; Attar, Ricardo M.; Carboni, Joan M.; Lee, Adrian V. 分享 收藏
Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor) Siddiqui, Bilal A.; Chapin, Brian F.; Jindal, Sonali; Duan, Fei; Basu, Sreyashi; Yadav, Shalini S.; Gu, Ai-Di; Espejo, Alexsandra B.; Kinder, Michelle; Pettaway, Curtis A.; Ward, John F.; Tidwell, Rebecca S. S.; Troncoso, Patricia; Corn, Paul G.; Logothetis, Christopher J.; Knoblauch, Roland; Hutnick, Natalie; Gottardis, Marco; Drake, Charles G.; Sharma, Padmanee; Subudhi, Sumit K. 分享 收藏
Safety and preliminary immunogenicity of JNJ-64041809, a live-attenuated, double-deleted Listeria monocytogenes-based immunotherapy, in metastatic castration-resistant prostate cancer 基于减毒双缺失单核细胞增生李斯特菌的免疫疗法JNJ-64041809在转移性去势抵抗性前列腺癌中的安全性和初步免疫原性 Drake, Charles G.; Pachynski, Russell K.; Subudhi, Sumit K.; McNeel, Douglas G.; Antonarakis, Emmanuel S.; Bauer, Todd M.; Lauer, Peter; Brockstedt, Dirk; Patricia, Daniel; Wade, Mark; Zudaire, Enrique; Bandyopadhyay, Nibedita; Parasrampuria, Dolly A.; Girgis, Suzette; Mason, Gary E.; Knoblauch, Roland E.; Stone, Nicole; Infante, Jeffrey R.; Gottardis, Marco M.; Fong, Lawrence 分享 收藏
Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer Branch, Jonathan R.; Bush, Tammy L.; Pande, Vineet; Connolly, Peter J.; Zhang, Zhuming; Hickson, Ian; Ondrus, Janine; Jaensch, Steffen; Bischoff, James R.; Habineza, Georges; Van Hecke, Geert; Meerpoel, Lieven; Packman, Kathryn; Parrett, Christopher J.; Chong, Yolanda T.; Gottardis, Marco M.; Bignan, Gilles 分享 收藏
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors Richters, Andre; Doyle, Shelby K.; Freeman, David B.; Lee, Christina; Leifer, Becky S.; Jagannathan, Sajjeev; Kabinger, Florian; Koren, Jost Vrabic; Struntz, Nicholas B.; Urgiles, Julie; Stagg, Ryan A.; Curtin, Brice H.; Chatterjee, Deep; Mathea, Sebastian; Mikochik, Peter J.; Hopkins, Tamara D.; Gao, Hua; Branch, Jonathan R.; Xin, Hong; Westover, Lori; Bignan, Gilles C.; Rupnow, Brent A.; Karlin, Kristen L.; Olson, Calla M.; Westbrook, Thomas F.; Vacca, Joseph; Wilfong, Chris M.; Trotter, B. Wesley; Saffran, Douglas C.; Bischofberger, Norbert; Knapp, Stefan; Russo, Joshua W.; Hickson, Ian; Bischoff, James R.; Gottardis, Marco M.; Balk, Steven P.; Lin, Charles Y.; Pop, Marius S.; Koehler, Angela N. 分享 收藏
Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC) Zhang, Zhuming; Connolly, Peter J.; Lim, Heng Keang; Pande, Vineet; Meerpoel, Lieven; Teleha, Christopher; Branch, Jonathan R.; Ondrus, Janine; Hickson, Ian; Bush, Tammy; Luistro, Leopoldo; Packman, Kathryn; Bischoff, James R.; Ibrahim, Salam; Parrett, Christopher; Chong, Yolanda; Gottardis, Marco M.; Bignan, Gilles 分享 收藏
Antitumor activity of JNJ-63576253 (TRC253), a small molecule antagonist of F877L mutant and wild-type androgen receptor Bush, Tammy L.; Ndikuyeze, Georges Habineza; Bignan, Gilles; Branch, Jonathan; Ondrus, Janine; Shi, Yifan; Luistro, Leopoldo; Hastings, James; Erhardt, Joseph; Hickson, Ian; Patel, Shefali; Connolly, Peter; Zhang, Zhuming; Bischoff, James; Rupnow, Brent; Gottardis, Marco; Packman, Kathryn 分享 收藏
Development of JNJ-64164711, a low fucose anti-GITR antibody for enhanced depletion of tumor regulatory T cells (Tregs) Holland, Cam V.; Kehoe, John; Hailey, Judith; Nanjunda, Rupesh; Lacy, Eilyn; Ernst, Robin; Zhang, Di; Wu, Sam; Teplyakov, Alexey; Li, Weimin; Kinder, Michelle; Thompson, Edward W.; Wilkinson, Patrick; Wong, Jackson; Chu, Gerald; Okonkwo, Linda; Alvarez, John D.; Anhco Nguyen; Grewal, Iqbal S.; Chatterjee-Kishore, Moitreyee; Salvati, Mark; Gottardis, Marco 分享 收藏
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Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer 用于治疗前列腺癌的选择性CYP17A1裂解酶抑制剂BMS-351的发现 Huang, Audris; Jayaraman, Lata; Fura, Aberra; Vite, Gregory D.; Trainor, George L.; Gottardis, Marco M.; Spires, Thomas E.; Spires, Vanessa M.; Rizzo, Cheryl A.; Obermeier, Mary T.; Elzinga, Paul A.; Todderud, Gordon; Fan, Yi; Newitt, John A.; Beyer, Sophie M.; Zhu, Yongxin; Warrack, Bethanne M.; Goodenough, Angela K.; Tebben, Andrew J.; Doweyko, Arthur M.; Gold, David L.; Balog, Aaron 分享 收藏
Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport Talbott, Randy L.; Borzilleri, Robert M.; Chaudhry, Charu; Fargnoli, Joseph; Shen, Henry; Fairchild, Craig; Barnhart, Bryan; Ortega, Marie; McDonagh, Thomas E.; Vuppugalla, Ragini; Vite, Gregory D.; Hunt, John T.; Gottardis, Marco; Naglich, Joseph G. 分享 收藏
Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer Balog, Aaron; Rampulla, Richard; Martin, Gregory S.; Krystek, Stanley R.; Attar, Ricardo; Dell-John, Janet; DiMarco, John D.; Fairfax, David; Gougoutas, Jack; Hoist, Christian L.; Nation, Andrew; Rizzo, Cheryl; Rossiter, Lana M.; Schweizer, Liang; Shan, Weifang; Spergel, Steven; Spires, Thomas; Cornelius, Georgia; Gottardis, Marco; Trainor, George; Vite, Gregory D.; Salvatit, Mark E. 分享 收藏
Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers Modugno, Michele; Banfi, Patrizia; Gasparri, Fabio; Borzilleri, Robert; Carter, Percy; Cornelius, Lyndon; Gottardis, Marco; Lee, Ving; Mapelli, Claudio; Naglich, Joseph G.; Tebben, Andrew; Vite, Gregory; Pastori, Wilma; Albanese, Clara; Corti, Emiliana; Ballinari, Dario; Galvani, Arturo 分享 收藏
A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor Emanuel, Stuart L.; Engle, Linda J.; Chao, Ginger; Zhu, Rong-Rong; Cao, Carolyn; Lin, Zheng; Yamniuk, Aaron; Hosbach, Jennifer; Brown, Jennifer; Fitzpatrick, Elizabeth; Gokemeijer, Jochem; Morin, Paul; Morse, Brent; Carvajal, Irvith M.; Fabrizio, David; Wright, Martin C.; Das Gupta, Ruchira; Gosselin, Michael; Cataldo, Daniel; Ryseck, Rolf P.; Doyle, Michael L.; Wong, Tai W.; Camphausen, Raymond T.; Cload, Sharon T.; Marsh, H. Nicholas; Gottardis, Marco M.; Furfine, Eric S. 分享 收藏
The Discovery of Potent and Selective Inhibitors of CYP17 Lyase Balog, A.; Jayaraman, L.; Fura, A.; Vite, G. D.; Gottardis, M.; Huang, A.; Newitt, J. A.; Spires, T. E.; Obermeier, M. T.; Beyer, S. M. 分享 收藏
Biochemical and transcriptional profiling to triage additional activities in a series of IGF-1R/IR inhibitors Ross-Macdonald, Petra; de Silva, Heshani; Patel, Vishal; Amy Truong; He, Aiqing; Neuhaus, Isaac; Tilford, Charles; Ji, RuiRu; Siemers, Nathan; Greer, Ann; Carboni, Joan; Gottardis, Marco; Menard, Krista; Lee, Frank; Dodier, Marco; Frennesson, David; Sampognaro, Anthony; Saulnier, Mark; Trainor, George; Vyas, Dolatrai; Zimmermann, Kurt; Wittman, Mark 分享 收藏
Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer Hou, Xiaonan; Huang, Fei; Macedo, Luciana F.; Harrington, Sean C.; Reeves, Karen A.; Greer, Ann; Finckenstein, Friedrich Graf; Brodie, Angela; Gottardis, Marco M.; Carboni, Joan M.; Haluska, Paul 分享 收藏
Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2 Purandare, A. V.; McDevitt, T. M.; Wan, H.; You, D.; Penhallow, B.; Han, X.; Vuppugalla, R.; Zhang, Y.; Ruepp, S. U.; Trainor, G. L.; Lombardo, L.; Pedicord, D.; Gottardis, M. M.; Ross-Macdonald, P.; de Silva, H.; Hosbach, J.; Emanuel, S. L.; Blat, Y.; Fitzpatrick, E.; Taylor, T. L.; McIntyre, K. W.; Michaud, E.; Mulligan, C.; Lee, F. Y.; Woolfson, A.; Lasho, T. L.; Pardanani, A.; Tefferi, A.; Lorenzi, M. V. 分享 收藏
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