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Synthesis and Structure-Activity Relationships of 8-(Pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: Potent, Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (CRF1) Antagonists Gilligan, Paul J.; Clarke, Todd; He, Liqi; Lelas, Snjezana; Li, Yu-Wen; Heman, Karen; Fitzgerald, Lawrence; Miller, Keith; Zhang, Ge; Marshall, Anne; Krause, Carol; McElroy, John F.; Ward, Kathyrn; Zeller, Kim; Wong, Harvey; Bai, Steven; Saye, Joanne; Grossman, Scott; Zaczek, Robert; Arneric, Stephen P.; Hartig, Paul; Robertson, David; Trainor, George 分享 收藏
8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: Selective and Centrally Active Corticotropin-Releasing Factor Receptor-1 (CRF1) Antagonists Gilligan, Paul J.; He, Liqi; Clarke, Todd; Tivitmahaisoon, Parcharee; Lelas, Snjezana; Li, Yu-Wen; Heman, Karen; Fitzgerald, Lawrence; Miller, Keith; Zhang, Ge; Marshall, Anne; Krause, Carol; McElroy, John; Ward, Kathyrn; Shen, Helen; Wong, Harvey; Grossman, Scott; Nemeth, Gregory; Zaczek, Robert; Arneric, Stephen P.; Hartig, Paul; Robertson, David W.; Trainor, George 分享 收藏
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Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats Lelas, S; Wong, H; Li, YW; Heman, KL; Ward, KA; Zeller, KL; Sieracki, KK; Polino, JL; Godonis, HE; Ren, SX; Yan, XX; Arneric, SP; Robertson, DW; Hartig, PR; Grossman, S; Trainor, GL; Taub, RA; Zaczek, R; Gilligan, PJ; McElroy, JF 分享 收藏
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Presenilin-1 and-2 are molecular targets for γ-secretase inhibitors Seiffert, D; Bradley, JD; Rominger, CM; Rominger, DH; Yang, FD; Meredith, JE; Tang, Q; Roach, AH; Thompson, LA; Spitz, SM; Higaki, JN; Prakash, SR; Combs, AP; Copeland, RA; Arneric, SP; Hartig, PR; Robertson, DW; Cordell, B; Stern, AM; Olson, RE; Zaczek, R 分享 收藏
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The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-α]-pyrimidine:: A corticotropin-releasing factor (hCRF1) antagonist Gilligan, PJ; Baldauf, C; Cocuzza, A; Chidester, D; Zaczek, R; Fitzgerald, LW; McElroy, J; Smith, MA; Shen, HSL; Saye, JA; Christ, D; Trainor, G; Robertson, DW; Hartig, P 分享 收藏
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