Louis‐Charles Campeau - Publications, H-index & Citations

Louis‐Charles Campeau

Merck & Co. Inc.

34H指数

146论文数

7.7K被引数

收录论文 57

发表时间

Discovery Process of Enlicitide; a Highly Engineered Macrocyclic Peptide Therapeutic; through Issue-Driven Fragment-Based Synthetic Assembly and SAR 通过问题驱动的片段基础合成组装和构效关系研究发现的恩利西肽；一种高度工程化的大环肽治疗药物

Journal of Medicinal Chemistry

IF6.8

2026-05-27

PREAI

Hubert Josien; Anilkumar G. Nair; Fa-Xiang Ding; Yan Guo; Yi-Heng Chen; Ashwin U. Rao; Jian Liu; Ling Tong; Zhongxiang Sun; Michael M.-C. Lo; Thomas J. Tucker; Mark W. Embrey; Aurash Shahripour; Chengwei Wu; Elisabetta Bianchi; Danila Branca; Jeffrey T. Kuethe; Joshua Lee; David A. Thaisrivongs; Paul G. Bulger; Xiaohong Zhu; Sookhee N. Ha; Jennifer M. Johnston; Daniel J. Klein; Peter Orth; Mee Ra Hong; Alexei V. Buevich; Qi Gao; Hratch J. Zokian; Kenneth A. Koeplinger; Rodger W. Tracy; Michael J. Hafey; Nicole Buist; Tjerk Bueters; Candice Alleyne; Alan Bass; Louis-Charles Campeau; Douglas G. Johns; Robert M. Garbaccio; Petr Vachal; Abbas Walji; Harold B. Wood

Biocatalytic cascades enable manufacture of the macrocyclic peptide enlicitide 生物催化级联实现大环肽enlicitide的制造

Science

IF45.8

2026-05-07

PREAI

Artis Klapars; Anna Fryszkowska; Stephanie Galanie; Omer Ad; Ellen Y. Aguilera; Nnamdi Akporji; Chihui An; Stephanus Axnanda; Tewoderos M. Ayele; Richard S. Ayikpoe; Rodell C. Barrientos; Matthew R. Bauerle; Marc R. Becker; Kevin M. Belyk; Lisa Bereznitski; Jackson K. B. Cahn; Karla Camacho Soto; Louis-Charles Campeau; Kevin R. Campos; Anagha Chandra; Hsieh Yao Darryl Chang; Mengbin Chen; Zhiwei Chen; Wai Ling Cheung-Lee; Cheol K. Chung; Stephanie W. Chun; Sarah S. Co; Ryan D. Cohen; Stephen M. Dalby; Guilherme Dal Poggetto; Truc Do; Spencer D. Dreher; Riki J. Drout; Noah P. Dunham; Yi Fan; Ryan M. Flessner; Jacob H. Forstater; Scott P. France; Janaka C. Gamekkanda; Donald R. Gauthier; Agnieszka A. Gil; Jacob W. Greenwood; Noel Ha; Holst M. Halsey; Xinxin Han; Michael Hartmann; Clara Hartmanshenn; Yu He; Edgar Hernandez; Kaori Hiraga; Hsing-I Ho; Cynthia M. Hong; Alan Hruza; Hang Hu; Kari Hullen; Alan M. Hyde; Tetsuji Itoh; Chey M. Jones; Woo-Ok Jung; Kanan Kanuga; James Levi Knippel; Joshua N. Kolev; Jongrock Kong; Birgit Kosjek; Sara Koynov; Michael H. Kress; Bharath Krishnamurthi; Jeffrey T. Kuethe; Thomas T. Kwok; Alfred Y. Lee; Joshua Lee; Qiuhan Li; Shasha Li; Jing Liao; Wenjun Liu; Gurpreet Longia; Emma Madrigal; Peter E. Maligres; Kevin M. Maloney; Erin L. McCarthy; John A. McIntosh; Samaneh Mesbahi-Vasey; Margaret Miller; Mansi Modi; Jeffrey C. Moore; Debopreeti Mukherjee; Grant S. Murphy; Jennifer Victoriano Obligacion; Weilan Pan; Julia Parzecki; Anisha Patel; Teng Peng; Byron K. Peters; Tiffany Piou; Carlos A. Pons Siepermann; Christopher K. Prier; Akasha K. Purohit; Yangzhong Qin; Erik L. Regalado; Mikhail Reibarkh; Nelo R. Rivera; Sandra A. Robaire; Lee Robison; Syamantak Roy; Rebecca T. Ruck; Katie A. Rykaczewski; Christopher H. Schuster; Erica L. Schwalm; Andrew N. Singh; Eric Sirota; Alexandra C. Sun; Weijuan Tang; David A. Thaisrivongs; Nimisha Thakur; Weidong Tong; Van Truong; Ryan Tsoi; Qiang Tu; Ben W. H. Turnbull; Ophelia Ukaegbu; David A. Vargas; Juan E. Velasquez; Deeptak Verma; Heather Wang; Tao Wang; Xiao Wang; Ying Wang; Zhixun Wang; Matthew S. Winston; Chunyu Wu; Brian M. Wyvratt; Kai-Jiong Xiao; Yingju Xu; Jia-Xuan Yan; Hao Yang; Victoria Zhang; Yongqian Zhang; Michelle Zheng; Wendy Zhong

The RAvIN Platform: A Noncarbohydrate Platform for Oligonucleotide Synthesis RAvIN平台：一种非碳水化合物寡核苷酸合成平台

Journal of the American Chemical Society

IF15.6

2026-03-18

PREAI

Matthew Nodwell; Guillermo Caballero-García; Juan M. Mesa; Tommi Muilu; Darryl M. Wilson; Abhishek Arora; Alan J. Brooke; Bara Singgh; Mamta Gill; Huyen M. Tran; Steven M. Silverman; Louis-Charles Campeau; Masad J. Damha; Robert Britton

A unified platform for nucleoside analog synthesis 核苷类似物合成的一体化平台

Science

IF45.8

2026-03-05

PREAI

Matthew J. Anketell; Ethan Fung; Wenbin Liu; Mahesh Shinde; Cyndi Qixin He; Kurtis W. C. Ng; Steven M. Silverman; Louis-Charles Campeau; Ralph Pantophlet; Robert Britton

Rapid Synthesis and Diversification of Thymine-Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions 通过级联环化反应实现胸腺嘧啶类桥联核酸的快速合成与多样化

Angewandte Chemie International Edition

IF0

2025-08-11

OAAI

Cohan Huxley; Ethan Fung; Dr. Bara Singh; Dr. Guillermo Caballero-García; Dr. Garrett Muir; Dr. Steven M. Silverman; Dr. Louis-Charles Campeau; Dr. Robert Britton

From Cortisone to Enlicitide: A Journey of Synthetic Chemistry Innovations at Merck

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2025-04-01

OAAI

Campeau, Louis-Charles

Total Synthesis of Enlicitide Decanoate 恩利西肽癸酸酯的全合成

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2025-03-24

PREAI

Li, Hongming; Thaisrivongs, David A.; Shang, Gao; Chen, Yonggang; Chen, Qinghao; Tan, Lushi; Xiao, Kai-Jiong; Larson, Reed T.; Kuethe, Jeffrey T.; Lee, Joshua; Deprez, Nicholas R.; Nolting, Andrew F.; Poirier, Marc; Bulger, Paul G.; Regalado, Erik L.; Biba, Mirlinda; Tsay, Fuh-Rong; Dasilva, Jimmy; Prier, Chris K.; Strulson, Christopher A.; Zawatzky, Kerstin; Liu, Zhu; Newman, Justin A.; Sokolowsky, Kathleen; Tang, Weijuan; Hullen, Kari; Thakur, Nimisha; Welch, Cody; Patel, Smit; He, Yu; Xu, Jing; Variankaval, Narayan; Klapars, Artis; Kong, Jongrock; Desmond, Richard; Varsolona, Richard; Maligres, Peter E.; Siepermann, Carlos A. Pons; Robison, Lee; Piou, Tiffany; Hartmanshenn, Clara; Chandra, Anagha; Patel, Anisha; Becker, Marc R.; Liu, Guiquan; Duan, Jianjun; Wan, Baoqiang; Xiao, Chengqian; Yuan, Yongpeng; Cao, Xiaohui; Chen, Lu; Yi, Ruxia; Wu, Zheng; Feng, Minyi; Li, Donghong; Song, Zhiyan; Dong, Yawei; Sun, Julin; Li, Biao; Shao, Guangxin; Campeau, Louis-Charles; Yin, Jingjun

Unmasking the halide effect in diastereoselective Grignard reactions applied to C4 modified nucleoside synthesis 揭示应用于C4修饰核苷合成的立体选择性格氏反应中的卤素效应

NATURE COMMUNICATIONS

IF15.7

2025-02-16

OAAI

Muir, Garrett; Caballero-Garcia, Guillermo; Muilu, Tommi; Nodwell, Matthew; Park, Yejin; Huxley, Cohan; Kaghad, Anissa; Silverman, Steven M.; Campeau, Louis-Charles; Barroso-Flores, Joaquin

A flexible and scalable synthesis of 4′-thionucleosides

CHEMICAL SCIENCE

IF7.4

2025-01-01

OAAI

Lucas, Callum; Fung, Ethan; Nodwell, Matthew; Silverman, Steven; Singh, Bara; Campeau, Louis-Charles; Britton, Robert

Thianthrenium ions pair-up for Suzuki-Miyaura reactions

NATURE SYNTHESIS

IF20

2024-08-26

PREAI

Campeau, Louis-Charles

Nickel-Catalyzed Reductive Arylation of Redox Active Esters for the Synthesis of α-Aryl Nitriles: Investigation of a Chlorosilane Additive

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2024-01-10

PREAI

Michel, Nicholas W. M.; Gabbey, Alexis L.; Edjoc, Racquel K.; Fagbola, Emmanuel; Hughes, Jonathan M. E.; Campeau, Louis-Charles; Rousseaux, Sophie A. L.

Should You Start a Chemistry Podcast?

ORGANIC LETTERS

IF5

2024-01-03

OAAI

Campeau, Louis-Charles; Horwitz, Matthew A.; Schultz, Danielle M.

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

CIRCULATION

IF38.6

2023-07-11

OAAI

Johns, Douglas G.; Campeau, Louis-Charles; Banka, Puja; Bautmans, An; Bueters, Tjerk; Bianchi, Elisabetta; Branca, Danila; Bulger, Paul G.; Crevecoeur, Inne; Ding, Fa-Xiang; Garbaccio, Robert M.; Guetschow, Erik D.; Guo, Yan; Ha, Sookhee N.; Johnston, Jennifer M.; Josien, Hubert; Kauh, Eunkyung A.; Koeplinger, Kenneth A.; Kuethe, Jeffrey T.; Lai, Eseng; Lanning, Christine L.; Lee, Anita Y. H.; Li, Li; Nair, Anilkumar G.; O'Neill, Edward A.; Stoch, S. Aubrey; Thaisrivongs, David A.; Tucker, Thomas J.; Vachal, Petr; van Dyck, Kristien; Vanhoutte, Frederic P.; Volckaert, Bram; Wolford, Dennis G.; Xu, Andy; Zhao, Tian; Zhou, Dan; Zhou, Susan; Zhu, Xiaohong; Zokian, Hratch J.; Walji, Abbas M.; Wood, Harold B.

Manufacturing Process Development for Uprifosbuvir (MK-3682): A Green and Sustainable Process for Preparing Penultimate 2′-Deoxy-α-2′-Chloro-β-2′-Methyluridine

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2022-08-16

PREAI

Maligres, Peter E.; Peng, Feng; Calabria, Ralph; Campeau, Louis-Charles; Chen, Wenyong; Dormer, Peter G.; Green, Meredith; He, Cyndi Qixin; Hyde, Alan M.; Klapars, Artis; Larsen, Mona Utne; Limanto, John; Liu, Guiquan; Liu, Yizhou; Moment, Aaron; Nowak, Timothy; Ruck, Rebecca T.; Shevlin, Michael; Song, Zhiguo Jake; Tan, Lushi; Tong, Weidong; Waldman, Jacob H.; Ye, Honglin; Zhao, Ralph; Zhou, George; Zompa, Michael A.; Zultanski, Susan L.

Total Synthesis of Darobactin A

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-07-28

PREAI

Nesic, Marko; Ryffel, David B.; Maturano, Jonathan; Shevlin, Michael; Pollack, Scott R.; Gauthier Jr, Donald R.; Trigo-Mourin, Pablo; Zhang, Li-Kang; Schultz, Danielle M.; Dunn, Jamie M. McCabe; Campeau, Louis-Charles; Patel, Niki R.; Petrone, David A.; Sarlah, David

Practical and concise synthesis of nucleoside analogs

NATURE PROTOCOLS

IF16

2022-07-04

OAAI

Davison, Emma K.; Petrone, David A.; Meanwell, Michael; Nodwell, Matthew B.; Silverman, Steven M.; Campeau, Louis-Charles; Britton, Robert

Synthesis of ?-Aryl Secondary Amides via Nickel-Catalyzed Reductive Coupling of Redox-Active Esters

ORGANIC LETTERS

IF5

2022-04-26

PREAI

Gabbey, Alexis L.; Michel, Nicholas W. M.; Hughes, Jonathan M. E.; Campeau, Louis-Charles; Rousseaux, Sophie A. L.

Driving Aspirational Process Mass Intensity Using Simple Structure-Based Prediction

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2022-04-18

OAAI

Sherer, Edward C.; Bagchi, Ansuman; Kosjek, Birgit; Maloney, Kevin M.; Peng, Zhengwei; Robaire, Sandra A.; Sheridan, Robert P.; Metwally, Essam; Campeau, Louis-Charles

Polycationic Rh-JosiPhos Polymers Supported on Phosphotungstic Acid/Al2O3 by Multiple Electrostatic Attractions

ACS CATALYSIS

IF13.1

2022-01-24

PREAI

Nepal, Prabin; Kalapugama, Suneth; Shevlin, Michael; Naber, John R.; Campeau, Louis-Charles; Pezzetta, Cristofer; Carlone, Armando; Cobley, Christopher J.; Bergens, Steven H.

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-08-10

PREAI

Vachal, Petr; Duffy, Joseph L.; Campeau, Louis-Charles; Amin, Rupesh P.; Mitra, Kaushik; Murphy, Beth Ann; Shao, Pengcheng P.; Sinclair, Peter J.; Ye, Feng; Katipally, Revathi; Lu, Zhijian; Ondeyka, Debra; Chen, Yi-Heng; Zhao, Kake; Sun, Wanying; Tyagarajan, Sriram; Bao, Jianming; Wang, Sheng-Ping; Cote, Josee; Lipardi, Concetta; Metzger, Daniel; Leung, Dennis; Hartmann, Georgy; Wollenberg, Gordon K.; Liu, Jian; Tan, Lushi; Xu, Yingju; Chen, Qinghao; Liu, Guiquan; Blaustein, Robert O.; Johns, Douglas G.

研究方向