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Q

Qing Mao

Shenyang Pharmaceutical University
H指数:15
被引数:526

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Design, Synthesis, and Biological Evaluation of 4-(Difluoromethyl)-1H-imidazole-5-carboxylic Acids/4-(3-Cyanophenoxy)pyrimidine-5-carboxylic Acids as P2Y1 Receptor Antagonists for Ischemic Stroke Treatment

4-(二氟甲基)-1H-咪唑-5-甲酸/4-(3-氰苯氧基)嘧啶-5-甲酸的设计、合成及其作为缺血性卒中治疗用P2Y1受体拮抗剂的生物评价

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-05-150
PRE
Zhang, Bing; Li, Jinxin; Li, Qi; Li, Qiuhua; Wang, Ruyu; Liu, Dan; Dai, Xiwen; Mao, Qing; Fu, Xuefeng; Zha, Wenhao; Lin, Fengwei; Wu, Chengjun; Mou, Yanhua
Scaffold hopping-based structural modification of tranilast led to the identification of HNW005 as a promising NLRP3 inflammasome and URAT1 dual inhibitor for the treatment of gouty arthritis

基于骨架跃迁的结构修饰对曲尼司特进行了改造，从而发现了HNW005，它是一种有前景的NLRP3炎性小体和URAT1双抑制剂，可用于治疗痛风性关节炎。

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2025-05-100
PRE
Sun, Ming; Lin, Fengwei; Yue, Chenchen; Wei, Zijie; Liu, Chang; Liu, Dan; Chen, Xing; Li, Qi; Liu, Ziyuan; Han, Jihong; Cui, Zichen; Mao, Qing; Li, Xinyu; Zhang, Peng; Zhang, Bing; Fu, Xuefeng; Wang, Han; Mou, Yanhua; Wang, Shaojie
Design, synthesis, and biological evaluation of N-(3-cyano-1H-indol-5/ 6-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamides and 5-(6-oxo-1,6-dihydropyrimidin-2-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors

N-(3-氰基-1h-吲哚-5/ 6-基)-6-氧代-1，6-二氢嘧啶-4-甲酰胺和5-(6-氧代-1，6-二氢嘧啶-2-基)-1h-吲哚-3-腈作为新型黄嘌呤氧化酶抑制剂的设计，合成和生物学评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2022-01-0122
PRE
Zhang, Bing; Duan, Yulin; Yang, Yuwei; Mao, Qing; Lin, Fengwei; Gao, Jun; Dai, Xiwen; Zhang, Peng; Li, Qiuhua; Li, Jinxin; Dai, Ronghua; Wang, Shaojie
Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives

靶向黄嘌呤氧化酶中的子口袋: 2-[4-烷氧基-3-(1h-四唑-1-基) 苯基]-6-氧代-1，6-二氢嘧啶-5-羧酸衍生物的设计，合成和生物学评估

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2019-11-0134
PREAI
Zhang, Bing; Dai, Xiwen; Bao, Ziyang; Mao, Qing; Duan, Yulin; Yang, Yuwei; Wang, Shaojie
Discovery of 1-Difluoromethyl-3-(3-cyanophenyl)-6-[4-(trifluoromethoxy)phenyl]imidazo[1; 5-a]pyrazin-8-(7H)-one as a Potent P2Y1 Antagonist for the Treatment of Ischemic Stroke and Myocardial Infarction

1-二氟甲基-3-(3-氰基苯基)-6-[4-(三氟甲氧基)苯基]咪唑并[1;5-a]吡嗪-8-(7H)-酮作为治疗缺血性中风和心肌梗死的强效P2Y1拮抗剂的发现

Journal of Medicinal Chemistry
IF6.8
0
PRE
Bing Zhang; Jinxin Li; Ruyu Wang; Qi Li; Qing Mao; Xuefeng Fu; Qingbo Song; Dan Liu; Xiwen Dai; Zhulin Du; Chang Liu; Ziyuan Liu; Xing Chen; Chengjun Wu; Yanhua Mou; Shaojie Wang

研究方向

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B
Bing Zhang
H 指数:29论文数:244被引数:2,825
F
Fengwei Lin
H 指数:9论文数:27被引数:191
X
Xiwen Dai
H 指数:8论文数:22被引数:255
S
Shaojie Wang
H 指数:17论文数:54被引数:651
Y
Yanhua Mou
H 指数:23论文数:97被引数:3,289
付
付雪峰
H 指数:6论文数:25被引数:119
J
Jiaxing Zhao
H 指数:31论文数:290被引数:4,445
Y
Yulin Duan
H 指数:22论文数:102被引数:1,912
B
Bing Zhang
H 指数:8论文数:17被引数:197
刘
刘丹
H 指数:89论文数:1,866被引数:3.9万