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H

Hans‐Joachim Lehmler

university of arizona health sciences

54H指数
451论文数
1.2W被引数
收录论文 216
发表时间
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ALDH1/2 deficiency modulates dieldrin-induced dopaminergic neurodegeneration and reactive glial morphometry in male miceALDH1/2 缺乏调节狄氏剂诱导的雄性小鼠多巴胺能神经元退变和反应性胶质细胞形态计量学
errFrontiers in Toxicology
IF4.6
err2026-09-16
err0
errOAAI
errOA Omar A. Yanouri; AJ Adam J. Schuller; SM Savannah M. Rocha; AM Aidan M. Briggs; PA Paul A. Martinez; EF Elizabeth Fernandez; RS Randy Strong; XL Xueshu Li; HL Hans-Joachim Lehmler; JA Jonathan A. Doorn; RB Ronald B. Tjalkens
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Neurodevelopmental outcomes relevant to autism in juvenile mice exposed to PCB 11 in the maternal diet throughout gestation and lactation孕期和哺乳期母体饮食暴露于PCB 11的幼年小鼠与自闭症相关的神经发育结局
errFrontiers in Toxicology
IF4.6
err2026-08-12
err0
errOAAI
errRJ Rebecca J. Wilson; HK Harmanpreet K. Panesar; ID Ilknur Dursun; RM Rosalia Mendieta; PM Peter M. Andrew; XL Xueshu Li; HL Hans-Joachim Lehmler; PJ Pamela J. Lein
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Developmental exposure to a human-relevant PCB mixture: impacts on PCB congeners, metabolites, and drug-metabolizing enzymes in the bladder of post-weaning mice
errArchives of Toxicology
IF6.9
err2026-07-04
err0
errOAAI
errHui Wang; Alex Goskowicz; Audrey Spiegelhoff; Conner L. Kennedy; Monica M. Ridlon; Rachel F. Marek; Hans-Joachim Lehmler; Kimberly P. Keil Stietz
err分享
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Morphological, Behavioral, and Transcriptomic Profiling Reveals Developmental Toxicity of PCB Metabolites in Zebrafish形态学、行为学和转录组学分析揭示了PCB代谢物在斑马鱼中的发育毒性
errToxics
IF4.1
err2026-05-19
err0
errOAAI
errNicole M. Breese; Lisa Truong; Xueshu Li; Robyn L. Tanguay; Hans-Joachim Lehmler
err分享
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Cytochrome P450-Mediated Xenobiotic Metabolism in the Brain, Effects of 3,3'-Dichlorobiphenyl (PCB-11) Exposure, and Contributions to Naphthalene-Induced DNA Adducts细胞色素P450介导的脑内外源性物质代谢，3,3'-二氯联苯（PCB-11）暴露的影响，以及对萘诱导DNA加合物的贡献
errJournal of Pharmacology and Experimental Therapeutics
IF3.8
err2026-05-01
err0
PREAI
errManhas, Diksha; Han, Weiguo; Wu, Xiangmeng; Hannon, Sarrah; Hollon, Michelle; Li, Xueshu; Zhang, Qing-Yu; Lehmler, Hans-Joachim; Van Winkle, Laura; Lein, Pamela J.; Ding, Xinxin
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Hepatic Biotransformation of 2,2′,5-Trichlorobiphenyl (PCB18) Is Comparable in Germ-Free and Conventional Mice2,2′,5-三氯联苯（PCB18）在无菌和常规小鼠中的肝脏生物转化具有可比性
errJournal of Pharmacology and Experimental Therapeutics
IF3.8
err2026-05-01
err0
PREAI
errBrobston, Sean; Li, Xuehsu; Suh, Youjun; Lehmler, Hans-Joachim; Cui, Julia
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Per-and Polyfluoroalkyl Substances Alter GPCR Activity全氟和多氟烷基物质改变G蛋白偶联受体活性
errJournal of Pharmacology and Experimental Therapeutics
IF3.8
err2026-05-01
err0
PREAI
errGentilman, Nathan; Wilkinson, Joshua; Lehmler, Hans-Joachim; Roman, David
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Neuroprotection Against a Panel of Toxicants via a Novel Analog of the Natural Product Fraxinellone通过天然产物Fraxinellone的一种新型类似物对一组毒物的神经保护作用
errChemical Research in Toxicology
IF3.8
err2026-04-22
err0
errOAAI
errAnna E. Bartman; Michael A. Garcia-Mares; Sarah E. Preston; Mersad Raeisi; Clarence D. Peiris; David B. C. Martin; Hans-Joachim Lehmler; Jonathan A. Doorn
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A Scoping Review of Neurotoxic and Behavioral Outcomes Following Polychlorinated Biphenyl (PCB) Exposure in Post-Weaned RodentsBreese, N.M.; Heim, S.G.; Samuelson, R.J.; Lehmler, H.J. 一项关于断奶后啮齿动物接触多氯联苯（PCB）后神经毒性和行为结局的范围综述。Int. J. Mol. Sci. 2025, 26, 10829. [Google Scholar] [CrossRef]
errInternational Journal of Molecular Sciences
IF4.9
err2026-03-03
err0
errOAAI
errNicole M. Breese; Sophia G. Heim; Riley J. Samuelson; Hans-Joachim Lehmler
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Emergency Preparedness in Older Adults With and Without COPD During Power Outages and Natural Disasters老年人在停电和自然灾害期间，有和无COPD患者的应急准备情况
errJournal of Applied Gerontology
IF2
err2026-03-01
err0
PREAI
errComellas, Alejandro P.; Stapleton, Emma M.; Janssen, Brandi; Lehmler, Hans-Joachim; Thorne, Peter S.; Curnick, Jacqueline; Sprenger, Kimberly; O'Connell, Deborah; Garcia, Eric; Bruening, Eric; Mittal, Aniket; Ashida, Sato
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Spatial transcriptomic profiling uncovers the molecular effects of the neurotoxicant polychlorinated biphenyls (PCBs) in the brains of adult mice空间转录组图谱揭示了成年小鼠大脑中神经毒性多氯联苯 (PCBs) 的分子效应
errMolecular Psychiatry
IF10.1
err2026-01-31
err0
errOAAI
errBudhaditya Basu; Nicole M. Breese; Sal Lombardi; Hui Wang; Xueshu Li; Destiny Tiburcio; Zachary Niemasz; Stacy E. Beyer; Laura E. Dean; Rachel F. Marek; Michal Toborek; Hans-Joachim Lehmler; Snehajyoti Chatterjee
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The Bladder as a Target for PCB Toxicity: Evidence from PCB Levels; Phase I Metabolite Levels; and Cytochrome P450 Expression Following Developmental Exposure to a Human-Relevant PCB Mixture in Mice
errChemical Research in Toxicology
IF3.8
err2026-01-22
err0
errOAAI
errHui Wang; Elaine A. Schumacher; Audrey Spiegelhoff; Conner L. Kennedy; Monica M. Ridlon; Rachel F. Marek; Kimberly P. Keil Stietz; Hans-Joachim Lehmler
err分享
err收藏
3,3'-Dichlorobiphenyl (PCB 11) alters the hepatic expression of cytochrome P450 enzymes in the liver of mouse dams exposed orally during pregnancy and lactation3,3'-Dichlorobiphenyl (PCB 11)改变了孕期和哺乳期经口暴露的母鼠肝脏中细胞色素P450酶的肝表达。
errArchives of Toxicology
IF6.9
err2025-12-08
err0
errOAAI
errCrystal M. Roach; Nate R. Koester; Xueshu Li; Jeonghyeon Ahn; R. Marshall Pope; Rebecca J. Wilson; Rosalia Mendieta; Anthony Valenzuela; Weiguo Han; Xinxin Ding; Pamela J. Lein; Hans-Joachim Lehmler
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Single-cell transcriptomics showed that maternal PCB exposure dysregulated cell type-specific metabolic responses in the livers of female mouse offsprings单细胞转录组学显示，母体PCB暴露扰乱了雌性小鼠后代肝脏中细胞类型特异性的代谢反应。
errDrug Metabolism and Disposition
IF4
err2025-09-25
err0
PREAI
errJoe Jongpyo Lim; Youjun Suh; Xueshu Li; Rebecca J. Wilson; Hans-Joachim Lehmler; Pamela J. Lein; Julia Yue Cui
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PCB 37 (3,4, 4’-trichlorobiphenyl) increased apoptosis and modulated neuronal morphogenesis in primary rat cortical neuron-glia cocultures in a concentration-, sex-, age-, and CREB-dependent mannerPCB 37 (3,4, 4’-trichlorobiphenyl) 以浓度依赖性、性别依赖性、年龄依赖性和CREB依赖性的方式增加了原代大鼠皮层神经元-胶质细胞共培养体系中的凋亡，并调节了神经元的形态发生。
errNeuroToxicology
IF3.9
err2025-08-19
err0
errOAAI
errJessie R. Badley; Peter M. Andrew; Hans-Joachim Lehmler; Pamela J. Lein
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Deconjugation of Polychlorinated Biphenyl Sulfates to Hydroxylated PCBs by Anaerobically Cultured Mouse and Human Gut Microbiota
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2025-03-01
err0
errOAAI
errLi, Xueshu; Lim, Joe J.; Rong, Cayen; Lehmler, Hans-Joachim; Cui, Julia Yue
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Investigating the Activity of Perfluoroalkyl Substances (PFASs) at the GPCRome研究全氟烷基物质（PFASs）在G蛋白偶联受体组中的活性
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2025-03-01
err0
PREAI
errGentilman, Nathan; Wilkinson, Joshua; Lehmler, Hans-Joachim; Roman, Dave
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Exposure to PCB52 (2,2′,5,5′-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose
errENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
IF4.2
err2025-01-01
err0
PREAI
errGourronc, Francoise A.; Bullert, Amanda J.; Helm-Kwasny, Brynn Kyleakin; Adamcakova-Dodd, Andrea; Wang, Hui; Jing, Xuefang; Li, Xueshu; Thorne, Peter S.; Lehmler, Hans-Joachim; Ankrum, James A.; Klingelhutz, Aloysius J.
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Effects of 28-day nose-only inhalation of PCB52 (2,2′,5,5′-Tetrachlorobiphenyl) on the brain transcriptome
errTOXICOLOGY
IF4.6
err2024-12-01
err0
PREAI
errBullert, Amanda J.; Wang, Hui; Linahon, Morgan J.; Chimenti, Michael S.; Adamcakova-Dodd, Andrea; Li, Xueshu; Dailey, Michael E.; Klingelhutz, Aloysius J.; Ankrum, James A.; Stevens, Hanna E.; Thorne, Peter S.; Lehmler, Hans-Joachim
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Inhalation of 2,2′,5,5′-tetrachlorobiphenyl (PCB52) causes changes to the gut microbiome throughout the gastrointestinal tract吸入2,2 ′，5,5 ′-四氯联苯 (PCB52) 引起整个胃肠道肠道微生物组的变化
errJOURNAL OF HAZARDOUS MATERIALS
IF11.3
err2024-12-01
err0
PREAI
errDean, Laura E.; Wang, Hui; Bullert, Amanda J.; Wanga, Hui; Adamcakova-Dodd, Andrea; Mangalam, Ashutosh K.; Thorne, Peter S.; Ankrum, James A.; Klingelhutz, Aloysius J.; Lehmler, Hans-Joachim
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研究方向

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合作学者
合作期刊
F
Frank B. Hu
H 指数: 244 · 论文数: 1.9K
K
Kurunthachalam Kannan
H 指数: 156 · 论文数: 1.2K
R
Robert B. Wallace
H 指数: 134 · 论文数: 1.1K
全燮 封面图
全燮 (Xie Quan)
H 指数: 121 · 论文数: 954
L
Linda S. Birnbaum
H 指数: 95 · 论文数: 618
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