David A. Orlando - Publications, H-index & Citations

David A. Orlando

yale university

22H指数

83论文数

1.3W被引数

收录论文 25

发表时间

The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs SLC1A1/EAAT3二羧基氨基酸转运蛋白是一种表观遗传失调的营养载体，能够维持致癌性代谢程序。

ONCOLOGIST

IF4.2

2025-10-01

OAAI

Grubb, Treg; Koochaki, Pooneh; Matar, Sayed; Ghandour, Fatme; Machaalani, Marc; Saad, Eddy; Tang, Cerise; Reznik, Eduard; Khatun, Jesminara; Salem, Carleigh; Dubasik, Noah; Orlando, David A.; Guenther, Matthew G.; Parajuli, Gyanu; Srivastava, Raghvendra M.; Martinez, Steven R.; Coker, Jesse; Kotecha, Ritesh; Hakimi, A. Ari; Asara, John; Chan, Timothy; Vanharanta, Sakari; Stauffer, Shaun; Kaelin, William G.; Signoretti, Sabina; Choueri, Toni; Chakraborty, Abhishek

Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7 CDK7的选择性共价抑制剂SY-1365的发现和表征

CANCER RESEARCH

IF16.6

2019-07-01

113

OAAI

Hu, Shanhu; Marineau, Jason J.; Rajagopal, Nisha; Hamman, Kristin B.; Choi, Yoon Jong; Schmidt, Darby R.; Ke, Nan; Johannessen, Liv; Bradley, Michael J.; Orlando, David A.; Alnemy, Sydney R.; Ren, Yixuan; Ciblat, Stephane; Winter, Dana K.; Kabro, Anzhelika; Sprott, Kevin T.; Hodgson, J. Graeme; Fritz, Christian C.; Carulli, John P.; di Tomaso, Emmanuelle; Olson, Eric R.

SY-1365, a selective CDK7 inhibitor, exhibits potent antitumor activity against ovarian cancer models in vitro and in vivo

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Konstantinopoulos, Panagiotis A.; Hodgson, Graeme; Rajagopal, Nisha; Johannessen, Liv; Liu, Joyce F.; Kirschmeier, Paul T.; Zhou, Shan; Cam Anh Tran; Orlando, David; Fritz, Christian; di Tomaso, Emmanuelle; Matulonis, Ursula A.

Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist

CANCER DISCOVERY

IF33.3

2017-10-02

112

OAAI

McKeown, Michael R.; Corces, M. Ryan; Eaton, Matthew L.; Fiore, Chris; Lee, Emily; Lopez, Jeremy T.; Chen, Mei Wei; Smith, Darren; Chan, Steven M.; Koenig, Julie L.; Austgen, Kathryn; Guenther, Matthew G.; Orlando, David A.; Loven, Jakob; Fritz, Christian C.; Majeti, Ravindra

Characterizing the Epigenetic Landscape Identifies Putative Therapeutic Targets in the Pancreatic Cancer Chimera

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

IF3.4

2017-10-01

OAAI

Sood, Divya; Austgen, Kathryn; Fiore, Chris; Orlando, David; Johnston, Brian; Miljovska, Sofija; Collins, Cindy; French, Randall; Lodie, Tracey; Lowy, Andrew M.

SY-1365, a potent and selective CDK7 inhibitor, exhibits promising anti-tumor activity in multiple preclinical models of aggressive solid tumors

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Hu, Shanhu; Ke, Nan; Ren, Yixuan; Miljovska, Sofija; Rajagopal, Nisha; McKeown, Michael; Orlando, David; Sprott, Kevin; Choi, Yoon J.; Olson, Eric; Fritz, Christian C.

Targeting the transcriptional kinases CDK12 and CDK13 in breast and ovarian cancer

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Bradley, Michael; Marineau, Jason; Choi, Yoon; Hamman, Kristin; Malojcic, Goran; Orlando, David; Ren, Yixuan; Ke, Nan; Hu, Shanhu; Olson, Eric; Fritz, Christian; Roberts, Christopher

Selective CDK7 inhibitors suppress super enhancer-genes, induce massive apoptosis in acute myeloid leukemia and demonstrate durable in vivo efficacy

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Hu, Shanhu; Ke, Nan; Ren, Yixuan; Lopez, Jeremy; Miljovska, Sofija; Orlando, David; Schmidt, Darby; Bradley, Michael; Sprott, Kevin; Olson, Eric; Fritz, Christian C.; Choi, Yoon Jong

Predicting drug response by profiling the epigenome: Super-enhancers as biomarkers

CANCER RESEARCH

IF16.6

2015-11-15

PREAI

Orlando, David A.; McKeown, Michael R.; Chen, Mei Wei; Collins, Cindy; Guenther, Matthew G.; Fritz, Christian C.

Predicting drug response by profiling the epigenome: Super-enhancers as biomarkers

CANCER RESEARCH

IF16.6

2015-11-15

PREAI

Orlando, David A.; McKeown, Michael R.; Chen, Mei Wei; Collins, Cindy; Guenther, Matthew G.; Fritz, Christian C.

Super-enhancers define breast cancer subclasses and identify novel tumor cell vulnerabilities

CANCER RESEARCH

IF16.6

2015-08-01

PREAI

Collins, Cindy; Chen, Mei Wei; Eaton, Matthew; Orlando, David; McKeown, Michael; Fritz, Christian; Olson, Eric; Guenther, Matthew

Super-enhancer analysis defines breast cancer subtype and identifies tumor dependencies

CANCER RESEARCH

IF16.6

2015-05-01

PREAI

Guenther, Matthew G.; Orlando, David A.; Eaton, Matthew L.; Collins, Cindy A.; Chen, Mei Wei; Solanki, Sneha; Loven, Jakob; Fritz, Christian C.; Olson, Eric R.

Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome 定量chip-seq归一化揭示了表观基因组的全局调节

CELL REPORTS

IF6.9

2014-11-01

389

OAAI

Orlando, David A.; Chen, Mei Wei; Brown, Victoria E.; Solanki, Snehakumari; Choi, Yoon J.; Olson, Eric R.; Fritz, Christian C.; Bradner, James E.; Guenther, Matthew G.

A Probabilistic model for cell cycle distributions in synchrony experiments

CELL CYCLE

IF3.4

2014-10-28

OAAI

Orlando, David A.; Lin, Charles Y.; Bernard, Allister; Iversen, Edwin S.; Hartemink, Alexander J.; Haase, Steven B.

Transcription network and cyclin/CDKs: The yin and yang of cell cy

CELL CYCLE

IF3.4

2014-10-28

OAAI

Kovacs, Laura A. Simmons; Orlando, David A.; Haase, Steven B.

Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements

STEM CELL REPORTS

IF5.1

2013-11-01

106

OAAI

Dowen, Jill M.; Bilodeau, Steve; Orlando, David A.; Huebner, Michael R.; Abraham, Brian J.; Spector, David L.; Young, Richard A.

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

CELL STEM CELL

IF20.4

2013-10-01

273

OAAI

Li, Yun; Wang, Haoyi; Muffat, Julien; Cheng, Albert W.; Orlando, David A.; Loven, Jakob; Kwok, Show-ming; Feldman, Danielle A.; Bateup, Helen S.; Gao, Qing; Hockemeyer, Dirk; Mitalipova, Maisam; Lewis, Caroline A.; Vander Heiden, Matthew G.; Sur, Mriganka; Young, Richard A.; Jaenisch, Rudolf

Cyclin-Dependent Kinases Are Regulators and Effectors of Oscillations Driven by a Transcription Factor Network (vol 45, pg 669, 2012)

MOLECULAR CELL

IF16.6

2013-03-01

OAAI

Kovacs, Laura A. Simmons; Mayhew, Michael B.; Orlando, David A.; Jin, Yuanjie; Li, Qingyun; Huang, Chenchen; Reed, Steven I.; Mukherjee, Sayan; Haase, Steven B.

Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-02-06

OAAI

Guo, Xin; Bernard, Allister; Orlando, David A.; Haase, Steven B.; Hartemink, Alexander J.

Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2013-02-04

407

OAAI

Sigova, Alla A.; Mullen, Alan C.; Molinie, Benoit; Gupta, Sumeet; Orlando, David A.; Guenther, Matthew G.; Almada, Albert E.; Lin, Charles; Sharp, Phillip A.; Giallourakis, Cosmas C.; Young, Richard A.

研究方向