Richard A. Young - Publications, H-index & Citations

Richard A. Young

Whitehead Institute for Biomedical Research

158H指数

702论文数

11.3W被引数

收录论文 153

发表时间

Transient gene melting governs the timing of oligodendrocyte maturation 瞬时基因融解调控少突胶质细胞成熟的时机

Cell

IF42.5

2025-08-25

PREAI

Kevin C. Allan; Jesse J. Zhan; Andrew R. Morton; Erin F. Cohn; Marissa A. Scavuzzo; Anushka Nikhil; Matthew S. Elitt; Benjamin L.L. Clayton; Lucille R. Hu; H. Elizabeth Shick; Jost K. Vrabic; Hannah E. Olsen; Daniel C. Factor; Jonathan E. Henninger; Gemma Bachmann; Berit E. Powers; Richard A. Young; Charles Y. Lin; Peter C. Scacheri; Tyler E. Miller; Paul J. Tesar

RNA and condensates: Disease implications and therapeutic opportunities

CELL CHEMICAL BIOLOGY

IF7.2

2024-09-01

OAAI

Han, Tina W.; Portz, Bede; Young, Richard A.; Boija, Ann; Klein, Isaac A.

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons MECP2直接与RNA聚合酶II相互作用以调节人神经元的转录

NEURON

IF15

2024-06-01

PREAI

Liu, Yi; Flamier, Anthony; Bell, George W.; Diao, Annette Jun; Whitfield, Troy W.; Wang, Hao-Che; Wu, Yizhe; Schulte, Fabian; Friesen, Max; Guo, Ruisi; Mitalipova, Maisam; Liu, X. Shawn; Vos, Seychelle M.; Young, Richard A.; Jaenisch, Rudolf

Regulatory architecture of cell identity genes and housekeeping genes

TRENDS IN CELL BIOLOGY

IF18.1

2023-12-01

OAAI

Dall'Agnese, Alessandra; Young, Richard

Distinct chemical environments in biomolecular condensates (Sep, 10.1038/s41589-023-01432-0, 2023)

NATURE CHEMICAL BIOLOGY

IF13.7

2023-10-25

OAAI

Kilgore, Henry R.; Mikhael, Peter G.; Overholt, Kalon J.; Boija, Ann; Hannett, Nancy M.; Van Dongen, Catherine; Lee, Tong Ihn; Chang, Young-Tae; Barzilay, Regina; Young, Richard A.

Distinct chemical environments in biomolecular condensates 生物分子缩合物中的不同化学环境

NATURE CHEMICAL BIOLOGY

IF13.7

2023-09-28

PREAI

Kilgore, Henry R.; Mikhael, Peter G.; Overholt, Kalon J.; Boija, Ann; Hannett, Nancy M.; Van Dongen, Catherine; Lee, Tong Ihn; Chang, Young-Tae; Barzilay, Regina; Young, Richard A.

Transcription factors interact with RNA to regulate genes

MOLECULAR CELL

IF16.6

2023-07-01

OAAI

Oksuz, Ozgur; Henninger, Jonathan E.; Warneford-Thomson, Robert; Zheng, Ming M.; Erb, Hailey; Vancura, Adrienne; Overholt, Kalon J.; Hawken, Susana Wilson; Banani, Salman F.; Lauman, Richard; Reich, Lauren N.; Robertson, Anne L.; Hannett, Nancy M.; Lee, Tong I.; Zon, Leonard I.; Bonasio, Roberto; Young, Richard A.

Regulatory architecture of housekeeping genes is driven by promoter assemblies

CELL REPORTS

IF6.9

2023-05-01

OAAI

Dejosez, Marion; Dall'Agnese, Alessandra; Ramamoorthy, Mahesh; Platt, Jesse; Yin, Xing; Hogan, Megan; Brosh, Ran; Weintraub, Abraham S.; Hnisz, Denes; Abraham, Brian J.; Young, Richard A.; Zwaka, Thomas P.

CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

OAAI

Sune, C; Hayashi, T; Liu, Y; Lane, WS; Young, RA; GarciaBlanco, MA

Yeast NC2 associates with the RNA polymerase II preinitiation complex and selectively affects transcription in vivo

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

OAAI

Geisberg, JV; Holstege, FC; Young, RA; Struhl, K

Interplay of positive and negative regulators in transcription initiation by RNA polymerase II holoenzyme

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Lee, TI; Wyrick, JJ; Koh, SS; Jennings, EG; Gadbois, EL; Young, RA

Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

139

OAAI

Balciunaite, E; Spektor, A; Lents, NH; Cam, H; Riele, HT; Scime, A; Rudnicki, MA; Young, R; Dynlacht, BD

The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance 胰岛素受体的动态聚集是其信号传导的基础，并在胰岛素抵抗中被破坏

NATURE COMMUNICATIONS

IF15.7

2022-12-06

OAAI

Dall'Agnese, Alessandra; Platt, Jesse M.; Zheng, Ming M.; Friesen, Max; Dall'Agnese, Giuseppe; Blaise, Alyssa M.; Spinelli, Jessica B.; Henninger, Jonathan E.; Tevonian, Erin N.; Hannett, Nancy M.; Lazaris, Charalampos; Drescher, Hannah K.; Bartsch, Lea M.; Kilgore, Henry R.; Jaenisch, Rudolf; Griffith, Linda G.; Cisse, Ibrahim I.; Jeppesen, Jacob F.; Lee, Tong I.; Young, Richard A.

Targeting transcription in heart failure via CDK7/12/13 inhibition 通过CDK7/12/13抑制靶向转录在心力衰竭中的作用

NATURE COMMUNICATIONS

IF15.7

2022-07-27

OAAI

Hsu, Austin; Duan, Qiming; Day, Daniel S.; Luo, Xin; McMahon, Sarah; Huang, Yu; Feldman, Zachary B.; Jiang, Zhen; Zhang, Tinghu; Liang, Yanke; Alexanian, Michael; Padmanabhan, Arun; Brown, Jonathan D.; Lin, Charles Y.; Gray, Nathanael S.; Young, Richard A.; Bruneau, Benoit G.; Haldar, Saptarsi M.

Genetic variation associated with condensate dysregulation in disease 与疾病中冷凝物失调相关的遗传变异

DEVELOPMENTAL CELL

IF8.7

2022-07-01

OAAI

Banani, Salman F.; Afeyan, Lena K.; Hawken, Susana W.; Henninger, Jonathan E.; Dall'Agnese, Alessandra; Clark, Victoria E.; Platt, Jesse M.; Oksuz, Ozgur; Hannett, Nancy M.; Sagi, Ido; Lee, Tong Ihn; Young, Richard A.

Learning the chemical grammar of biomolecular condensates

NATURE CHEMICAL BIOLOGY

IF13.7

2022-06-27

OAAI

Kilgore, Henry R.; Young, Richard A.

The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes

CELL STEM CELL

IF20.4

2022-05-01

OAAI

Ma, Haiting; de Zwaan, Esmee; Guo, Yang Eric; Cejas, Paloma; Thiru, Prathapan; van de Bunt, Martijn; Jeppesen, Jacob F.; Syamala, Sudeepa; Dall'Agnese, Alessandra; Abraham, Brian J.; Fu, Dongdong; Garrett-Engele, Carrie; Lee, Tong Ihn; Long, Henry W.; Griffith, Linda G.; Young, Richard A.; Jaenisch, Rudolf

Predicting master transcription factors from pan-cancer expression data

SCIENCE ADVANCES

IF12.5

2021-11-26

OAAI

Reddy, Jessica; Fonseca, Marcos A. S.; Corona, Rosario, I; Nameki, Robbin; Dezem, Felipe Segato; Klein, Isaac A.; Chang, Heidi; Chaves-Moreira, Daniele; Afeyan, Lena K.; Malta, Tathiane M.; Lin, Xianzhi; Abbasi, Forough; Font-Tello, Alba; Sabedot, Thais; Cejas, Paloma; Rodriguez-Malave, Norma; Seo, Ji-Heui; Lin, De-Chen; Matulonis, Ursula; Karlan, Beth Y.; Gayther, Simon A.; Pasaniuc, Bogdan; Gusev, Alexander; Noushmehr, Houtan; Long, Henry; Freedman, Matthew L.; Drapkin, Ronny; Young, Richard A.; Abraham, Brian J.; Lawrenson, Kate

RNA in formation and regulation of transcriptional condensates RNA在转录缩合物的形成和调控中的作用

RNA

IF5

2021-11-12

OAAI

Sharp, Phillip A.; Chakraborty, Arup K.; Henninger, Jonathan E.; Young, Richard A.

REPLY TO BRIGGS ET AL.: Genomic integration and expression of SARS-CoV-2 sequences can explain prolonged or recurrent viral RNA detection

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-10-25

OAAI

Zhang, Liguo; Richards, Alexsia; Barrasa, M. Inmaculada; Hughes, Stephen H.; Young, Richard A.; Jaenisch, Rudolf

研究方向