未登录 Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis Zhang, Xiaojun; Jiang, Wen; Richter, Jeremy M.; Bates, J. Alex; Reznik, Samuel K.; Stachura, Sylwia; Rampulla, Richard; Doddalingappa, Dyamanna; Ulaganathan, Sankar; Hua, Ji; Bostwick, Jeffrey S.; Sum, Chi; Posy, Shana; Malmstrom, Sarah; Dickey, Joyce; Harden, David; Lawrence, R. Michael; Guarino, Victor R.; Schumacher, William A.; Wong, Pancras; Yang, Jing; Gordon, David A.; Wexler, Ruth R.; Priestley, Scott 分享 收藏
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4 Priestley, E. Scott; Banville, Jacques; Deon, Daniel; Dube, Laurence; Gagnon, Marc; Guy, Julia; Lapointe, Philippe; Lavallee, Jean-Francois; Martel, Alain; Plamondon, Serge; Remillard, Roger; Ruediger, Edward; Tremblay, Francois; Posy, Shana L.; Guarino, Victor R.; Richter, Jeremy M.; Li, Jianqing; Gupta, Anuradha; Vetrichelvan, Muthalagu; Balapragalathan, T. J.; Mathur, Arvind; Hua, Ji; Callejo, Mario; Guay, Jocelyne; Sum, Chi Shing; Cvijic, Mary Ellen; Watson, Carol; Wong, Pancras; Yang, Jing; Bouvier, Michel; Gordon, David A.; Wexler, Ruth R.; Marinier, Anne 分享 收藏
Milvexian, an orally bioavailable, small-molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits Milvexian，一种口服生物可利用的，小分子的，可逆的，XIa因子的直接抑制剂: 兔实验性血栓形成的体外研究和体内评估 Wong, Pancras C.; Crain, Earl J.; Bozarth, Jeffrey M.; Wu, Yiming; Dilger, Andrew K.; Wexler, Ruth R.; Ewing, William R.; Gordon, David; Luettgen, Joseph M. 分享 收藏
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy Dilger, Andrew K.; Pabbisetty, Kumar B.; Corte, James R.; De Lucca, Indawati; Fang, Tianan; Yang, Wu; Pinto, Donald J. P.; Wang, Yufeng; Zhu, Yeheng; Mathur, Arvind; Li, Jianqing; Hou, Xiaoping; Smith, Daniel; Sun, Dawn; Zhang, Huiping; Krishnananthan, Subramaniam; Wu, Dauh-Rurng; Myers, Joseph E., Jr.; Sheriff, Steven; Rossi, Karen A.; Chacko, Silvi; Zheng, Joanna J.; Galella, Michael A.; Ziemba, Theresa; Dierks, Elizabeth A.; Bozarth, Jeffrey M.; Wu, Yiming; Crain, Earl; Wong, Pancras C.; Luettgen, Joseph M.; Wexler, Ruth R.; Ewing, William R. 分享 收藏
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure Gargalovic, Peter; Wong, Pancras; Onorato, Joelle; Finlay, Heather; Wang, Tao; Yan, Mujing; Crain, Earl; St-Onge, Stephane; Heroux, Madeleine; Bouvier, Michel; Xu, Carrie; Chen, Xue-Qing; Generaux, Claudia; Lawrence, Michael; Wexler, Ruth; Gordon, David 分享 收藏
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species Yang, Wu; Wang, Yufeng; Lai, Amy; Clark, Charles G.; Corte, James R.; Fang, Tianan; Gilligan, Paul J.; Jeon, Yoon; Pabbisetty, Kumar B.; Rampulla, Richard A.; Mathur, Arvind; Kaspady, Mahammed; Neithnadka, Premsai Rai; Arumugam, Arunachalam; Raju, Sivashankaran; Rossi, Karen A.; Myers, Joseph E., Jr.; Sheriff, Steven; Lou, Zhen; Zheng, Joanna J.; Chacko, Silvi A.; Bozarth, Jeffrey M.; Wu, Yiming; Crain, Earl J.; Wong, Pancras C.; Seiffert, Dietmar A.; Luettgen, Joseph M.; Lam, Patrick Y. S.; Wexler, Ruth R.; Ewing, William R. 分享 收藏
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups Corte, James R.; Pinto, Donald J. P.; Fang, Tianan; Osuna, Honey; Yang, Wu; Wang, Yufeng; Lai, Amy; Clark, Charles G.; Sun, Jung-Hui; Rampulla, Richard; Mathur, Arvind; Kaspady, Mahammed; Neithnadka, Premsai Rai; Li, Yi-Xin Cindy; Rossi, Karen A.; Myers, Joseph E., Jr.; Sheriff, Steven; Lou, Zhen; Harper, Timothy W.; Huang, Christine; Zheng, Joanna J.; Bozarth, Jeffrey M.; Wu, Yiming; Wong, Pancras C.; Crain, Earl J.; Seiffert, Dietmar A.; Luettgen, Joseph M.; Lam, Patrick Y. S.; Wexler, Ruth R.; Ewing, William R. 分享 收藏
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy Miller, Michael M.; Banville, Jacques; Friends, Todd J.; Gagnon, Mark; Hangeland, Jon J.; Lavallee, Jean-Francois; Martel, Alain; O'Grady, Harold; Remillard, Roger; Ruediger, Edward; Tremblay, Francois; Posy, Shana L.; Allegretto, Nick J.; Guarino, Victor R.; Harden, David G.; Harper, Timothy W.; Hartl, Karen; Josephs, Jonathan; Malmstrom, Sarah; Watson, Carol; Yang, Yanou; Mang, Ge; Wong, Pancras; Yang, Wongjing; Bouvier, Michel; Seiffert, Dietmar A.; Wexler, Ruth R.; Lawrence, R. Michael; Priestley, E. Scott; Marinier, Anne 分享 收藏
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Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis Bergmeier, Wolfgang; Antoniak, Silvio; Conway, Edward M.; Denis, Cecile V.; George, Lindsey A.; Isermann, Berend; Key, Nigel S.; Krishnaswamy, Sriram; Lam, Wilbur A.; Lillicrap, David; Liu, Jian; Looney, Mark R.; Lopez, Jose A.; Maas, Coen; Peyvandi, Flora; Ruf, Wolfram; Sood, Anil K.; Versteeg, Henri H.; Wolberg, Alisa S.; Wong, Pancras C.; Wood, Jeremy P.; Weiler, Hartmut 分享 收藏
Atropisomer Control in Macrocyclic Factor Vlla Inhibitors (vol 59, pg 4007, 2016) Glunz, Peter W.; Mueller, Luciano; Cheney, Daniel L.; Ladziata, Vladimir; Zou, Yan; Wurtz, Nicholas R.; Wei, Anzhi; Wong, Pancras C.; Wexler, Ruth R.; Priestley, E. Scott 分享 收藏
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Discovery of a Parenteral Small Molecule Coagulation Factor Xla Inhibitor Clinical Candidate (BMS-962212) Pinto, Donald J. P.; Orwat, Michael J.; Smith, Leon M., II; Quan, Mimi L.; Lam, Patrick Y. S.; Rossi, Karen A.; Apedo, Atsu; Bozarth, Jeffrey M.; Wu, Yiming; Zheng, Joanna J.; Xin, Baomin; Toussaint, Nathalie; Stetsko, Paul; Gudmundsson, Olafur; Maxwell, Brad; Crain, Earl J.; Wong, Pancras C.; Lou, Zhen; Harper, Timothy W.; Chacko, Silvi A.; Myers, Joseph E., Jr.; Sheriff, Steven; Zhang, Huiping; Hou, Xiaoping; Mathur, Arvind; Seiffert, Dietmar A.; Wexler, Ruth R.; Luettgen, Joseph M.; Ewing, William R. 分享 收藏
Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding Wong, Pancras C.; Seiffert, Dietmar; Bird, J. Eileen; Watson, Carol A.; Bostwick, Jeffrey S.; Giancarli, Mary; Allegretto, Nick; Hua, Ji; Harden, David; Guay, Jocelyne; Callejo, Mario; Miller, Michael M.; Lawrence, R. Michael; Banville, Jacques; Guy, Julia; Maxwell, Brad D.; Priestley, E. Scott; Marinier, Anne; Wexler, Ruth R.; Bouvier, Michel; Gordon, David A.; Schumacher, William A.; Yang, Jing 分享 收藏
Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors Richter, Jeremy M.; Cheney, Daniel L.; Bates, J. Alex; Wei, Anzhi; Luettgen, Joseph M.; Rendina, Alan R.; Harper, Timothy M.; Narayanan, Rangaraj; Wong, Pancras C.; Seiffert, Dietmar; Wexler, Ruth R.; Priestley, E. Scott 分享 收藏
Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors Wurtz, Nicholas R.; Parkhurst, Brandon L.; Jiang, Wen; DeLucca, Indawati; Zhang, Xiaojun; Ladziata, Vladimir; Cheney, Daniel L.; Bozarth, Jeffrey R.; Rendina, Alan R.; Wei, Anzhi; Luettgen, Joseph M.; Wu, Yiming; Wong, Pancras C.; Seiffert, Dietmar A.; Wexler, Ruth R.; Priestley, E. Scott 分享 收藏
Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex Zhang, Xiaojun; Glunz, Peter W.; Johnson, James A.; Jiang, Wen; Jacutin-Porte, Swanee; Ladziata, Vladimir; Zou, Yan; Phillips, Monique S.; Wurtz, Nicholas R.; Parkhurst, Brandon; Rendina, Alan R.; Harper, Timothy M.; Cheney, Daniel L.; Luettgen, Joseph M.; Wong, Pancras C.; Seiffert, Dietmar; Wexler, Ruth R.; Priestley, E. Scott 分享 收藏
Differential Cardiac Effects of an AT1R Biased Ligand, AT1R Antagonist and ACE Inhibitor in Mouse Models of Post-Myocardial Infarction Heart Failure Ma, Xiuying; Tannu, Shahid; Allocco, John; Qiu, Dike; Flaim, Marisa; Crain, Earl; Bostwick, Jeffrey; Smith, Patricia; Chen, Xue-Qing; Schumacher, William; Arey, Brian J.; Wong, Pancras 分享 收藏
Atropisomer Control in Macrocyclic Factor VIIa Inhibitors Glunz, Peter W.; Mueller, Luciano; Cheney, Daniel L.; Ladziata, Vladimir; Zou, Yan; Wurtz, Nicholas R.; Wei, Anzhi; Wong, Pancras C.; Wexler, Ruth R.; Priestley, E. Scott 分享 收藏
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