Brian G. Lake - Publications, H-index & Citations

Brian G. Lake

university of nebraska medical center

56H指数

317论文数

1.2W被引数

收录论文 69

发表时间

The use of cultured human hepatocytes as a test system to evaluate cell proliferation as a key event in nongenotoxic carcinogenesis 利用培养的人肝细胞作为测试系统，评估细胞增殖作为非遗传毒性致癌作用中的关键事件

Archives of Toxicology

IF6.9

2026-05-05

OAAI

David E. Cowie; Samuel M. Cohen; Manuela Goettel; Brian G. Lake; Stephanie Nadzialek; Uku Rooni; Maaike E. Schutte; Helen Tinwell; Josh Turiccki; Tomoya Yamada; Christian Strupp

Response to the Letter from Professor C. R. Wolf and colleagues concerning CRT, 55: 549-586, 2025: The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome-proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation 对C. R. Wolf教授及其同事关于CRT，55: 549-586, 2025来信的回应：激活组成型雄烷受体（CAR）和过氧化物增殖物激活受体α（PPARα）诱导啮齿动物肝脏肿瘤形成的机制与人癌症风险无关：一项更新的关键性评价

Critical Reviews in Toxicology

IF4.1

2026-01-01

PREAI

Yamada, Tomoya; Cohen, Samuel M.; Lake, Brian G.

Mode of Action Analysis for Mouse Liver Tumor Formation by MGK-264 and Human Relevance MGK-264和人类相关性对小鼠肝脏肿瘤形成的作用机制分析

Regulatory Toxicology and Pharmacology

IF3.5

2025-08-20

OAAI

Junji Yano; Kensuke Kawamoto; Yukako Shimotsuma; Keiko Ogata; Kohei Matsunaga; Jun Abe; Satoki Fukunaga; Thomas G. Osimitz; Brian G. Lake; Hiroyuki Asano

The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation CAR（组成型雄烷受体）和PPARα（过氧化物增殖物激活受体α）激活剂导致啮齿动物肝脏肿瘤形成的机制与人类癌症风险无关：一项更新的关键性评估

Critical Reviews in Toxicology

IF4.1

2025-06-27

OAAI

Tomoya Yamada; Samuel M. Cohen; Brian G. Lake

Mode of action analysis for rat thyroid gland follicular cell tumor formation by MGK-264 and human relevance MGK-264对大鼠甲状腺腺体滤泡细胞肿瘤形成的作用机制分析及其对人类的相关性

REGULATORY TOXICOLOGY AND PHARMACOLOGY

IF3.5

2025-05-13

PREAI

Yano, Junji; Kawamoto, Kensuke; Shimotsuma, Yukako; Matsunaga, Kohei; Abe, Jun; Fukunaga, Satoki; Osimitz, Thomas G.; Lake, Brian G.; Asano, Hiroyuki

Mode of action analysis for fluxapyroxad-induced rat liver tumour formation: evidence for activation of the constitutive androstane receptor and assessment of human relevance

TOXICOLOGY

IF4.6

2024-06-01

PREAI

Goettel, Manuela; Werner, Christoph; Honarvar, Naveed; Groeters, Sibylle; Fegert, Ivana; Haines, Corinne; Chatham, Lynsey R.; Vardy, Audrey; Lake, Brian G.

Response to Letter to the Editor from Drs. van Kesteren, Pronk, Heusinkveld, Luijten and Hakkert concerning Yamada et al. (2021): Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Crit. Rev. Toxicol. Vol. 51: 373-394

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2022-08-16

PREAI

Yamada, Tomoya; Cohen, Samuel M.; Lake, Brian G.

Evaluation of the human hazard of the liver and lung tumors in mice treated with permethrin based on mode of action

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2022-03-11

OAAI

Yamada, Tomoya; Lake, Brian G.; Cohen, Samuel M.

Club Cells Are the Primary Target for Permethrin-Induced Mouse Lung Tumor Formation

TOXICOLOGICAL SCIENCES

IF4.1

2021-08-24

PREAI

Ogata, Keiko; Liu, Yang; Ohara, Ayako; Kawamoto, Kensuke; Kondo, Miwa; Kobayashi, Kumiko; Fukuda, Takako; Asano, Hiroyuki; Kitamoto, Sachiko; Lake, Brian G.; Cohen, Samuel M.; Yamada, Tomoya

Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)

CRITICAL REVIEWS IN TOXICOLOGY

IF4.1

2021-07-15

OAAI

Yamada, Tomoya; Cohen, Samuel M.; Lake, Brian G.

Differential lymphatic versus portal vein uptake of the synthetic pyrethroids deltamethrin and cis-permethrin in rats

TOXICOLOGY

IF4.6

2020-10-01

PREAI

Higgins, Larry G.; Chatham, Lynsey R.; Tomczynski, Sara L.; MacLeod, A. Kenneth; Moreau, Marjory; Clewell, Harvey J.; Yoon, Miyoung; Creek, Moire R.; Osimitz, Thomas G.; Lake, Brian G.

Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice

TOXICOLOGICAL SCIENCES

IF4.1

2020-07-31

OAAI

Yamada, Tomoya; Ohara, Ayako; Ozawa, Naoya; Maeda, Keiko; Kondo, Miwa; Okuda, Yu; Abe, Jun; Cohen, Samuel M.; Lake, Brian G.

Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance

TOXICOLOGY

IF4.6

2020-06-01

PREAI

Lake, Brian G.; Price, Roger J.; Scott, Mary P.; Chatham, Lynsey R.; Vardy, Audrey; Osimitz, Thomas G.

Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids

TOXICOLOGICAL SCIENCES

IF4.1

2020-05-18

OAAI

Mallick, Pankajini; Song, Gina; Efremenko, Alina Y.; Pendse, Salil N.; Creek, Moire R.; Osimitz, Thomas G.; Hines, Ronald N.; Hinderliter, Paul; Clewell, Harvey J.; Lake, Brian G.; Yoon, Miyoung; Moreau, Marjory

Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats

TOXICOLOGY

IF4.6

2020-03-01

PREAI

Goettel, Manuela; Fegert, Ivana; Honarvar, Naveed; Vardy, Audrey; Haines, Corinne; Chatham, Lynsey R.; Lake, Brian G.

An Evaluation of the Human Relevance of the Liver Tumors Observed in Female Mice Treated With Permethrin Based on Mode of Action

TOXICOLOGICAL SCIENCES

IF4.1

2020-02-10

PREAI

Kondo, Miwa; Kikumoto, Hiroko; Osimitz, Thomas G.; Cohen, Samuel M.; Lake, Brian G.; Yamada, Tomoya

Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital

TOXICOLOGY

IF4.6

2020-01-01

PREAI

Sidaway, James E.; Orton, Terry C.; Kalaitzi, Kassiani; Jones, Huw B.; Foster, Alison; Lake, Brian G.

Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans

TOXICOLOGICAL SCIENCES

IF4.1

2019-10-08

OAAI

Mallick, Pankajini; Moreau, Marjory; Song, Gina; Efremenko, Alina Y.; Pendse, Salil N.; Creek, Moire R.; Osimitz, Thomas G.; Hines, Ronald N.; Hinderliter, Paul; Clewell, Harvey J.; Lake, Brian G.; Yoon, Miyoung

Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance

TOXICOLOGY

IF4.6

2019-10-01

PREAI

Wiemann, Christiane; Goettel, Manuela; Vardy, Audrey; Elcombe, Barbara M.; Elcombe, Clifford R.; Chatham, Lynsey R.; Wang, Hongbing; Li, Linhao; Buesen, Roland; Honarvar, Naveed; Treumann, Silke; Marxfeld, Heike; Groeters, Sibylle; Lake, Brian G.

Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation

TOXICOLOGICAL SCIENCES

IF4.1

2019-02-15

PREAI

Song, Gina; Moreau, Marjory; Efremenko, Alina; Lake, Brian G.; Wu, Huali; Bruckner, James V.; White, Catherine A.; Osimitz, Thomas G.; Creek, Moire R.; Hinderliter, Paul M.; Clewell, Harvey J.; Yoon, Miyoung

研究方向